| CAMARA DE MERCADEO INDUSTRIA Y | Guaynabo | S46 Community Improvement & Capacity Building | $2.7M | 1 |
| HTAS DE LOS ANCIANOS DESAMPARADOS HOGAR STA TERESA JORNET DE CUPEY | San Juan | P20 Human Services | $2.7M | 1 |
| PROYECTO NACER INC | Bayamon | P45 Human Services | $2.7M | 2 |
| ASOCIACION DE HOSPITALES DE PUERTO RICO | San Juan | E99 Health Care | $2.7M | 1 |
| FONDO DE INVERSION Y DESARROLLO COOPERATIVO | San Juan | S30 Community Improvement & Capacity Building | $2.7M | 2 |
| SERVICIOS SOCIALES EPISCOPALES INC | Trujillo Alto | P30 Human Services | $2.6M | 0 |
| FUNDACION DE NINOS DE PUERTO RICO INC | San Juan | E99 Health Care | $2.6M | 1 |
| ESPERANZA PARA LA VEJEZ INC | Bayamon | P20Z Human Services | $2.6M | 1 |
| SHALOM FACILITY INC URB ROYAL TOWN | Bayamon | P82 Human Services | $2.5M | 2 |
| CENTRO DE PERIODISMO INVESTIGATIVO INC | San Juan | A33 Arts, Culture & Humanities | $2.5M | 3 |
| PROYECTO MATRIA INC | Caguas | P43 Human Services | $2.5M | 3 |
| REHACIENDO COMUNIDADES CON | San Juan | P20 Human Services | $2.5M | 5 |
| 2022 ACT FOUNDATION INC | Dorado | T30 Philanthropy, Voluntarism & Grantmaking Foundations | $2.5M | 1 |
| PUERTO RICO BASEBALL ACADEMY AND | Caguas | B25 Education | $2.4M | 0 |
| HERMANITAS DE LOS ANCIANOS DESAMPARADOS HOGAR SANTA MARTA | Mercedita | E91 Health Care | $2.4M | 1 |
| ASOCIACION DE INTERCAMBIO CULTURAL INC | Guaynabo | P200 Human Services | $2.3M | 0 |
| PUERTO RICO CENTRO DE ARTES Y TECNOLOGIA CORP | San Juan | A25 Arts, Culture & Humanities | $2.3M | 0 |
| PRO VIVIENDAS I INC | San Juan | L20 Housing & Shelter | $2.3M | 1 |
| ADVANCE LEADERSHIP FOUNDATION INC | San Juan | W70 Public & Societal Benefit | $2.3M | 1 |
| FUNDACION EDUCATIVA CONCEPCION | Fajardo | B20 Education | $2.2M | 3 |
| SOUTHWESTERN EDUCATION SOCIETY | Mayaguez | B99Z Education | $2.2M | 3 |
| Society For Human Resource Management Puerto Rico Chapter | San Juan | B03 Education | $2.2M | 1 |
| KatherineJames Foundation | Dorado | T90 Philanthropy, Voluntarism & Grantmaking Foundations | $2.2M | 0 |
| MOVIMIENTO PARA EL ALCANCE DE VIDA INDEPENDIENTE | San Juan | P20 Human Services | $2.2M | 1 |
| THE JANE STERN DORADO COMMUNITY LIBRARY INC | Dorado | B71Z Education | $2.1M | 0 |
| LICEO PONCENO INC | Ponce | B24 Education | $2.1M | 0 |
| PRO VIVIENDAS II INC | San Juan | L210 Housing & Shelter | $2.1M | 1 |
| BOY SCOUTS OF AMERICA | Guaynabo | — | $2.1M | 0 |
| CORPORACION PARA LA CONSERVACION ETNOECOLOGICA CRIOLLA INC | Caguas | C36 Environment | $2.1M | 1 |
| ASOCIACION PRO JUVENTUD Y COMUNIDAD DE BARRIO PALMAS INC | Catano | S20M Community Improvement & Capacity Building | $2.1M | 1 |
| World Boxing Organization Inc | San Juan | — | $2M | 1 |
| Ponce Neighborhood Housing Services Inc | Ponce | L20Z Housing & Shelter | $2M | 4 |
| ASOCIACION HECHO EN PUERTO RICO INC | San Juan | S41 Community Improvement & Capacity Building | $2M | 2 |
| PLENITUD INICIATIVAS | Las Marias | C30 Environment | $2M | 3 |
| CENTRO DE DIAGNOSTICO PARA INTELIGENCIAS MULTIPLES INC | San Juan | P80 Human Services | $1.9M | 0 |
| HERMANITAS DE LOS ANCIANOS DESAMPARADOS INC | San Juan | P80 Human Services | $1.9M | 0 |
| CENTER FOR A NEW ECONOMY INC | San Juan | B90 Education | $1.9M | 6 |
| Auditorium De Amor Kennedy Inc | San Juan | X20 Religion-Related | $1.9M | 0 |
| ENTERPRIZE EVENTS INC | San Juan | S30 Community Improvement & Capacity Building | $1.9M | 0 |
| COALICION DE COALICIONES PRO PERSONAS SIN HOGAR DE PUERTO RICO | Ponce | P85 Human Services | $1.9M | 1 |
| PATRONATO CASTILLO SERRALLES | Ponce | A50 Arts, Culture & Humanities | $1.8M | 0 |
| CREARTE INC | San Juan | A25 Arts, Culture & Humanities | $1.8M | 0 |
| FUNDACIN LUIS MUOZ MARIN INC | San Juan | — | $1.8M | 3 |
| MCS FOUNDATION INC | San Juan | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $1.8M | 0 |
| INTERCAMBIOS PUERTO RICO INC | Fajardo | E70 Health Care | $1.8M | 1 |
| UNIVERSIDAD TEOLOGICA DEL CARIBE IN | Trujillo Alto | B99 Education | $1.7M | 2 |
| Centro Criollo de Ciencias y Technologia Inc | Caguas | A50 Arts, Culture & Humanities | $1.7M | 1 |
| MOLECULAR SCIENCES RESEARCH CENTER INC | San Juan | U99 Science & Technology | $1.7M | 2 |
| DR LUIS BAEZ DIAZ BREAST CANCER FOUNDATION OF PUERTO RICO | San Juan | G32 Diseases, Disorders & Medical Disciplines | $1.7M | 0 |
| FUNDACION DE DESARROLLO COMUNAL DE P R INC | Caguas | L410 Housing & Shelter | $1.7M | 1 |
