| Historic Columbia Foundation | Columbia | A82I Arts, Culture & Humanities | $3.1M | 3 |
| LAURENS EDUCATION ASSISTANCE FOR DISTRICT NO 55 | Laurens | B11 Education | $3.1M | 0 |
| THE SUNSHINE FOUNDATION INC | Barnwell | T20Z Philanthropy, Voluntarism & Grantmaking Foundations | $3.1M | 0 |
| TRIDENT TECHNICAL COLLEGE FOUNDATION INC | Charleston | B11 Education | $3.1M | 1 |
| Tap Cancer Out Inc | Indian Land | N12 Recreation & Sports | $3.1M | 4 |
| TYGER RIVER FOUNDATION | Spartanburg | C32 Environment | $3.1M | 0 |
| Plumbers & Pipefitters Local 421 | North Charleston | — | $3.1M | 4 |
| TRIDENT ACADEMY INC | Mt Pleasant | B28Z Education | $3.1M | 1 |
| THE ANMED HEALTH FOUNDATION | Anderson | E11 Health Care | $3.1M | 5 |
| Charleston Redevelopment Corporation | Charleston | S31 Community Improvement & Capacity Building | $3M | 1 |
| FAMILY CONNECTION OF SOUTH CAROLINA INC | Columbia | P40Z Human Services | $3M | 0 |
| Christian Services Inc | Lancaster | P20 Human Services | $3M | 0 |
| EAST LINK ACADEMY | Greenville | B29 Education | $3M | 0 |
| Adult Enrichment Centers Inc | Rock Hill | P700 Human Services | $3M | 1 |
| PEE DEE MATH SCIENCE & TECHNOLOGY | Bishopville | B29 Education | $3M | 1 |
| THE SOUTH CAROLINA HISTORICAL SOCIETY | Charleston | A82Z Arts, Culture & Humanities | $3M | 3 |
| PALMETTO GOLF CLUB | Aiken | — | $3M | 2 |
| CHARLESTON JUNIOR GOLF FOUNDATION | Mount Pleasant | N6A Recreation & Sports | $3M | 1 |
| CALHOUN FALLS CHARTER SCHOOL | Calhoun Falls | B29 Education | $3M | 0 |
| DISABILITY RIGHTS SOUTH CAROLINA INC | Columbia | R23Z Civil Rights, Social Action & Advocacy | $3M | 3 |
| CHILD ABUSE PREVENTION ASSOCIATION | Beaufort | I72Z Crime & Legal-Related | $3M | 1 |
| CENTER FOR DEVELOPMENTAL SERVICES | Greenville | P110 Human Services | $3M | 1 |
| POPLAR SPRINGS FIRE SERVICE AREA INC | Moore | — | $2.9M | 1 |
| THE REINHARDT FAMILY FOUNDATION TRUST | Sullivans Island | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $2.9M | 0 |
| CAROLINAS CREDIT UNION LEAGUE 4248 | Columbia | — | $2.9M | 6 |
| LB FOUNDATION | Greenville | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $2.9M | 2 |
| MOTHER EMANUEL MEMORIAL FOUNDATION | Charleston | R20 Civil Rights, Social Action & Advocacy | $2.9M | 1 |
| PALMETTO ACADEMY FOR LEARNING MOTORSPORTS | Conway | B29 Education | $2.9M | 1 |
| BIBLE STUDY TIME INC | Spartanburg | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $2.9M | 1 |
| Habitat for Humanity of York County Inc | Rock Hill | — | $2.9M | 1 |
| PETS INC OF THE MIDLANDS | West Columbia | D200 Animal-Related | $2.9M | 2 |
| PEE DEE ACADEMY | Mullins | — | $2.9M | 0 |
| MODERN MINDS | Mount Pleasant | F32 Mental Health & Crisis Intervention | $2.9M | 2 |
| THE COOPER RIVER BRIDGE RUN INC | Mount Pleasant | N60 Recreation & Sports | $2.9M | 1 |
| HIGH HILLS RURAL WATER CO INC | Dalzell | W80 Public & Societal Benefit | $2.9M | 1 |
| ONE ELEUTHERA FOUNDATION | Clemson | O12 Youth Development | $2.9M | 1 |
| EASTERN CAROLINA COMMUNITY FOUNDATION | Florence | T31 Philanthropy, Voluntarism & Grantmaking Foundations | $2.9M | 1 |
| LEE ACADEMY OF BISHOPVILLE INC | Bishopville | — | $2.9M | 1 |
| COLUMBIA HOUSING AUTHORITY DEVELOPMENT | Columbia | — | $2.9M | 0 |
| SC CHAMBER OF COMMERCE | Columbia | — | $2.8M | 4 |
| PEE DEE HEALTHY START INC | Florence | E42 Health Care | $2.8M | 1 |
| THE PRESERVATION SOCIETY OF CHARLESTON INC | Charleston | — | $2.8M | 2 |
| CLEMSON ALUMNI ASSOCIATION | Clemson | B12 Education | $2.8M | 3 |
| CHILDREN'S CANCER PARTNERS OF THE CAROLINAS INC | Spartanburg | O50 Youth Development | $2.8M | 3 |
| SOUTH CAROLINA EDUCATION ASSOCIATION | West Columbia | — | $2.8M | 4 |
| Hope Inc | Rock Hill | P600 Human Services | $2.8M | 1 |
| Pine Ridge Fire Department | Summerville | M24 Public Safety, Disaster Preparedness & Relief | $2.8M | 0 |
| Dorchester Academy Inc | Saint George | — | $2.8M | 1 |
| BELLE W BARUCH FOUNDATION | Georgetown | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $2.8M | 1 |
| HORRY-GEORGETOWN TECHNICAL COLLEGE FOUNDATION INC | Conway | B110 Education | $2.8M | 0 |
