| The Life House Womens Shelter Inc | Rock Hill | L41 Housing & Shelter | $1.6M | 2 |
| DAWN LAUREL FOUNDATION | Clemson | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $1.6M | 0 |
| PALMETTO STATE GROWTH FUND INC | Columbia | W11 Public & Societal Benefit | $1.6M | 0 |
| UPSTATE HOMESCHOOL CO-OP INC | Taylors | B99 Education | $1.6M | 2 |
| ONESPARTANBURG INC FOUNDATION | Spartanburg | T50 Philanthropy, Voluntarism & Grantmaking Foundations | $1.6M | 0 |
| CAMP HAPPY DAYS INC | Charleston | — | $1.6M | 1 |
| HOLDING SEVEN COMMUNITY DEVELOPMENT | Bluffton | P99 Human Services | $1.6M | 0 |
| FAIRWAY FORD INC VOLUNTARY | Greenville | — | $1.6M | 0 |
| HIS WAY AT WORK | Spartanburg | X20 Religion-Related | $1.6M | 4 |
| CAPITAL CITYLAKE MURRAY COUNTRY | Irmo | — | $1.6M | 1 |
| JAMES ISLAND PRESBYTERIAN | Charleston | P200 Human Services | $1.6M | 0 |
| The William and Mary Buckley Foundation | Charleston | — | $1.6M | 0 |
| LANCASTER COUNTY COUNCIL ON AGING | Lancaster | P81Z Human Services | $1.6M | 1 |
| NEWBERRY ACADEMY INC | Newberry | — | $1.6M | 1 |
| ANIMAL ALLIES INC | Spartanburg | D200 Animal-Related | $1.6M | 1 |
| HARPER FAMILY FOUNDATION | Greenville | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $1.6M | 0 |
| THE CHILDREN'S CENTER INC | Hilton Head Island | P33Z Human Services | $1.6M | 1 |
| EDISTO ISLAND OPEN LAND TRUST | Edisto Island | C340 Environment | $1.6M | 1 |
| GREATER GREENVILLE ASSOCIATION OF | Greenville | — | $1.6M | 2 |
| PHILLIPS CHARITABLE FOUNDATION | Charleston | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $1.6M | 3 |
| SPANISH WELLS CLUB | Hilton Head Island | — | $1.6M | 0 |
| SC Foster Parent Association | Elgin | P190 Human Services | $1.6M | 0 |
| The Springs Close Foundation Inc | Fort Mill | — | $1.6M | 1 |
| MULTIMEDIA THEOLOGICAL TRAINING | Greenville | X20 Religion-Related | $1.6M | 0 |
| THE MEETING PLACE CHURCH INTERNATIONAL | Columbia | X20 Religion-Related | $1.6M | 1 |
| CAPSTONE GLOBAL INITIATIVE INC | Pawleys Island | X20 Religion-Related | $1.6M | 1 |
| NEW DIRECTIONS OF HORRY COUNTY INC | Myrtle Beach | P20 Human Services | $1.6M | 1 |
| GLENFOREST SCHOOL | West Columbia | B28Z Education | $1.6M | 0 |
| SUSTAINABILITY INSTITUTE | North Charleston | S20 Community Improvement & Capacity Building | $1.6M | 2 |
| BRIDGES OF HOPE | North Charleston | P74Z Human Services | $1.6M | 0 |
| Mid-Carolina Area Health Education Cons | Lancaster | — | $1.5M | 1 |
| SOUTH CAROLINA I-77 ALLIANCE | Richburg | S30 Community Improvement & Capacity Building | $1.5M | 2 |
| SOUTH CAROLINA MUSIC EDUCATORS | Spartanburg | B99 Education | $1.5M | 3 |
| RONALD MCDONALD HOUSE | Columbia | P40Z Human Services | $1.5M | 2 |
| CHRIST FREEDOM HOME INC | Taylors | F21 Mental Health & Crisis Intervention | $1.5M | 2 |
| Boys & Girls Club of Kershaw County | Columbia | O23 Youth Development | $1.5M | 1 |
| ALL 4 PAWS | Pawleys Island | D20 Animal-Related | $1.5M | 1 |
| MIDLANDS COMMUNITY DEVELOPMENT CORP | Columbia | L25 Housing & Shelter | $1.5M | 1 |
| MISSION EMANUEL | Spartanburg | X99 Religion-Related | $1.5M | 2 |
| DOORS TO FREEDOM | Summerville | I73 Crime & Legal-Related | $1.5M | 1 |
| CT TOWNSEND MINISTRIES INC | North Augusta | X20 Religion-Related | $1.5M | 1 |
| CHESTER CO COMM ON ALCHOHOL & DRUG | Chester | F20Z Mental Health & Crisis Intervention | $1.5M | 0 |
| GAMECOCK CLUB | Columbia | B99 Education | $1.5M | 0 |
| DICKERSON CHILDRENS ADVOCACY | Lexington | I72 Crime & Legal-Related | $1.5M | 2 |
| JUNIOR ACHIEVEMENT OF GREATER SOUTH | Columbia | Q320 International, Foreign Affairs & National Security | $1.5M | 1 |
| LEARN 4 LIFE - SOUTH CAROLINA | North Charleston | B29 Education | $1.5M | 0 |
| CHILDREN'S ADVOCACY CENTER OF | Spartanburg | I72 Crime & Legal-Related | $1.5M | 1 |
| SOUTH CAROLINA FIRST STEPS TO | Greenwood | B190 Education | $1.5M | 0 |
| NATIONAL ASSOCIATION OF STATE PARK | Columbia | — | $1.5M | 1 |
| CUMBEE CENTER TO ASSIST ABUSED PERSONS | Aiken | P43Z Human Services | $1.5M | 1 |
