| Bethune Rural Water Company Inc | Bethune | — | $750k | 7 |
| LAKESIDE COUNTRY CLUB OF LAURENS COUNTY | Laurens | — | $749k | 0 |
| AMERICAN COUNCIL OF ENGINEERING COMPANIE | Columbia | — | $747k | 0 |
| THE JIM PARKE FOUNDATION C/O MARILYN J PARKE | Seneca | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $747k | 0 |
| UNITED COMMUNITY BANK FOUNDATION | Greenville | T21 Philanthropy, Voluntarism & Grantmaking Foundations | $746k | 0 |
| The Baptist Courier | Greenville | X21Z Religion-Related | $746k | 3 |
| THE CHARLES W & ELIZABETH H COKER FOUNDATION C/O MR JOHN JAY JAMES II | Darlington | — | $745k | 0 |
| INTERNATIONAL FOUNDATION FOR GASTROINTESTINAL DISORDERS | Mt Pleasant | B99Z Education | $745k | 2 |
| CP NOW | Greenville | B60 Education | $745k | 1 |
| Fort Mill Care Center Inc | Fort Mill | P600 Human Services | $745k | 0 |
| UNITED CHRISTIAN MINISTRIES | Easley | P600 Human Services | $744k | 1 |
| SPARTANBURG COUNTY HISTORICAL ASSOC | Spartanburg | — | $744k | 0 |
| INDIAN WATERS COUNCIL ITA | Columbia | — | $743k | 0 |
| CLARITY INC | Greenville | — | $743k | 0 |
| NEXT GENERATION MINISTRIES | Lexington | Q33 International, Foreign Affairs & National Security | $743k | 0 |
| THE RAPE CRISIS CENTER SERVING HORRY AND GEORGETOWN COUNTIES INC | Myrtle Beach | B90 Education | $742k | 0 |
| BC Corp | Greenville | B28 Education | $741k | 1 |
| SOUTH CAROLINA ECONOMIC DEVELOPERS' ASSOCIATION | Columbia | — | $740k | 0 |
| SCSDB FOUNDATION | Spartanburg | — | $740k | 0 |
| BEYOND BASIC LIFE SKILLS | Summerville | P80 Human Services | $740k | 2 |
| MERRIWETHER VOLUNTEER FIRE DEPARTMENT | North Augusta | — | $739k | 0 |
| WALLACE WATER COMPANY INCORPORATED | Wallace | — | $738k | 8 |
| LEE COUNTY COUNCIL ON AGING | Bishopville | — | $737k | 0 |
| LOWCOUNTRY LEGAL VOLUNTEERS | Bluffton | I80 Crime & Legal-Related | $737k | 1 |
| BETTER BUSINESS BUREAU OF THE UPSTATE INC | Greenville | — | $736k | 1 |
| GREEN KNOLL FOUNDATION | Pelzer | O52 Youth Development | $734k | 0 |
| Daniel-Mickel Foundation | Greenville | — | $734k | 5 |
| UPSTATE EMS COUNCIL INC | Greenville | — | $733k | 1 |
| SOUTH CAROLINA FIRST STEPS TO SCHOOL READINESS - CHEROKEE COUNTY | Greenwood | B012 Education | $733k | 1 |
| SAMMYS MISSION | Simpsonville | F20 Mental Health & Crisis Intervention | $732k | 0 |
| WE ARE FAMILY | North Charleston | R20 Civil Rights, Social Action & Advocacy | $730k | 1 |
| GIVING MINISTRY FOUNDATION | Graniteville | T12 Philanthropy, Voluntarism & Grantmaking Foundations | $730k | 0 |
| BREAD OF LIFE MISSIONS | Hanahan | P20 Human Services | $729k | 2 |
| ROCK THE BLOCK INC | Charleston | G12 Diseases, Disorders & Medical Disciplines | $729k | 0 |
| LEXINGTON MEDICAL CENTER AUXILIARY LEXINGTON COUNTY HOSPITAL AUXILIARY | West Columbia | — | $728k | 0 |
| PLUMBERS & PIPEFITTERS LU 421 LABOR MANAGEMENT FUND | N Charleston | J40 Employment | $727k | 0 |
| GOOD NEIGHBOR FREE MEDICAL CLINIC OF BEAUFORT | Beaufort | E322 Health Care | $727k | 2 |
| GIBBS CHARITABLE FOUNDATION | Spartanburg | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $725k | 0 |
| THE HARTNESS FOUNDATION ROBERT G HARTNESS | Greer | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $721k | 0 |
| DEFEND THE FATHERLESS INC | Fort Mill | P20 Human Services | $721k | 1 |
| BEAUFORT WATER FESTIVAL | Beaufort | — | $720k | 0 |
| FC CHARLESTON | Mount Pleasant | N64 Recreation & Sports | $720k | 0 |
| Better Business Bureau Inc | Columbia | — | $720k | 1 |
| R-LCOA HOUSING DEVELOPMENT CORP INC | Columbia | L200 Housing & Shelter | $718k | 0 |
| ARROWS ACADEMY OF SOUTH CAROLINA | Columbia | B24 Education | $716k | 3 |
| TENACIOUS GRACE MINISTRIES INC | Florence | X20 Religion-Related | $716k | 3 |
| FLORENCE COUNTY DISABILITIES FOUNDATION | Lake City | P82Z Human Services | $716k | 1 |
| SANTUCK HEBRON WATER COMPANY INC | Carlisle | K20 Food, Agriculture & Nutrition | $715k | 0 |
| THE SAMARITAN HOUSE OF ORANGEBURG COUNTY INC | Orangeburg | P20 Human Services | $715k | 0 |
| HILTON HEAD AREA REALTORS | Hilton Head Island | — | $714k | 1 |
