| WILD HEARTS EQUINE THERAPY CENTER | Seneca | E50 Health Care | $638k | 0 |
| MECHANICAL CONTRACTORS ASSOCIATION | Columbia | — | $637k | 1 |
| NATIONAL AFRICAN AMERICAN RVers | Columbia | N50 Recreation & Sports | $636k | 0 |
| THE CHILDREN'S RESEARCH AND EDUCATION | Charleston | — | $636k | 2 |
| SPARTANBURG COMMUNITY COLLEGE | Spartanburg | B19 Education | $633k | 4 |
| LOAVES AND FISHES | Greenville | K300 Food, Agriculture & Nutrition | $633k | 1 |
| SANDALWOOD COMMUNITY FOOD PANTRY | Hilton Head Island | K31 Food, Agriculture & Nutrition | $631k | 1 |
| COASTAL EXPEDITIONS FOUNDATION | Mt Pleasant | C30 Environment | $630k | 0 |
| South Carolina Technical College | Columbia | B30J Education | $628k | 1 |
| SUMTER BOARD OF REALTORS INC | Sumter | — | $627k | 1 |
| MOST WORSHIPFUL PRINCE HALL GRAND | Columbia | — | $623k | 14 |
| MOUNT PLEASANT SWIM CLUB PARENTS | Mount Pleasant | N116 Recreation & Sports | $623k | 0 |
| ALLEN TEMPLE COMMUNITY ECONOMIC | Greenville | S31 Community Improvement & Capacity Building | $622k | 0 |
| MIDLANDS HOUSING TRUST FUND | Columbia | L20 Housing & Shelter | $621k | 1 |
| Balmer Foundation | Spartanburg | T11 Philanthropy, Voluntarism & Grantmaking Foundations | $621k | 0 |
| MILL TOWN PLAYERS | Pelzer | A20 Arts, Culture & Humanities | $621k | 0 |
| LOUVENIA D BARKSDALE SICKLE CELL ANEMIA FOUNDATIO | Spartanburg | G22Z Diseases, Disorders & Medical Disciplines | $621k | 7 |
| School Ministries Inc | Columbia | B99Z Education | $621k | 0 |
| SLATER MARIETTA HEALTH AND HUMAN | Slater | — | $621k | 1 |
| UNION COUNTY YMCA | Union | P27Z Human Services | $620k | 1 |
| Flourish Adoption Ministries Inc | Greenville | B90 Education | $619k | 1 |
| Benevolent Protective Order of | Manning | — | $619k | 0 |
| FRIENDS OF THE HUNLEY INC | North Charleston | A99 Arts, Culture & Humanities | $618k | 0 |
| AMERICAN INSTITUTE OF ARCHITECTS | Columbia | — | $618k | 1 |
| VERTICAL LIFT CONSORTIUM INC | Summerville | — | $615k | 0 |
| LEE AND SUMTER COUNTY ALLIANCE | Sumter | S30 Community Improvement & Capacity Building | $615k | 0 |
| LOVE IN ACTION INTERNATIONAL MINISTRIES | Summerville | X200 Religion-Related | $615k | 0 |
| NORTH WALTERBORO CHRISTIAN ACADEMY | Walterboro | B20 Education | $614k | 0 |
| ANIMAL PROTECTION LEAGUE OF SOUTH CAROLINA | West Columbia | D200 Animal-Related | $614k | 0 |
| CHEROKEE COUNTY MEALS ON WHEELS | Gaffney | K36Z Food, Agriculture & Nutrition | $614k | 0 |
| COMMUNITY INITIATIVES INC | Greenwood | P20 Human Services | $614k | 1 |
| SHERIAR FOUNDATION | Myrtle Beach | — | $613k | 0 |
| SUMMERVILLE HOME EDUCATORS | Summerville | — | $611k | 0 |
| MCDOWELL HOUSING CORPORATION | Greenville | L20Z Housing & Shelter | $611k | 0 |
| SOUTH CAROLINA ASSOCIATION OF | Columbia | — | $611k | 0 |
| BIRTHMATTERS | Spartanburg | — | $610k | 0 |
| SANTEE ELECTRIC TRUST | Kingstree | T00Z Philanthropy, Voluntarism & Grantmaking Foundations | $610k | 0 |
| Horry-Georgetown Home Builders Assoc | Conway | — | $608k | 1 |
| THE FRANKLIN G BURROUGHS | Myrtle Beach | A51I Arts, Culture & Humanities | $607k | 1 |
| 34 WEST THEATER COMPANY | Charleston | A60 Arts, Culture & Humanities | $607k | 0 |
| FULLER NORMAL AND INDUSTRIAL INSTITUTE | Greenville | — | $607k | 4 |
| OCONEE ECONOMIC ALLIANCE | Seneca | S41 Community Improvement & Capacity Building | $607k | 0 |
| LOWCOUNTRY HOCKEY ASSOCIATION | North Charleston | N68 Recreation & Sports | $607k | 4 |
| SIGMA ALPHA EPSILON FRATERNITY | Columbia | N50 Recreation & Sports | $606k | 0 |
| Habitat For Humanity International Inc | Wando | — | $605k | 2 |
| FRIENDS OF FISHER HOUSE CHARLESTON | Charleston | E86 Health Care | $605k | 0 |
| BLYTHEWOOD HISTORICAL SOCIETY & MUSEUM | Blythewood | A80 Arts, Culture & Humanities | $604k | 0 |
| PRISMA HEALTH BAPTIST EASLEY | Easley | E22I Health Care | $604k | 1 |
| FRIENDS OF COASTAL SOUTH CAROLINA | Mt Pleasant | C60 Environment | $603k | 0 |
| MEDICINAL WHISKEY CHARITY INC | Greenville | E12 Health Care | $603k | 0 |
