| SCOTTISH RITE BODIES IN THE VALLEY | Spartanburg | — | $337k | 0 |
| SAMPIT COMMUNITY ORGANIZATION | Georgetown | P33 Human Services | $337k | 1 |
| SRS HERITAGE FOUNDATION INC | Aiken | A80 Arts, Culture & Humanities | $337k | 1 |
| CHI OMEGA FRATERNITY-PSI KAPPA CHAP | Clemson | — | $337k | 0 |
| NORTH MYRTLE BEACH RESCUE SQUAD INC | North Myrtle Beach | — | $336k | 1 |
| Clemson Paw Partners | Clemson | D20 Animal-Related | $336k | 0 |
| COMMUNITY MUSEUM SOCIETY INC | Lake City | A500 Arts, Culture & Humanities | $336k | 0 |
| FRIENDS OF THE CHAS COUNTY LIBRARY | Charleston | B71I Education | $336k | 1 |
| MEDIATRIX SC INC | Greer | X84 Religion-Related | $335k | 0 |
| MUEHLSCHLEGEL TIMBERLANDS LLC | Estill | — | $334k | 0 |
| SOUTH CAROLINA FIRST STEPS TO | Greenwood | B012 Education | $334k | 0 |
| The Brotherton Foundation | Easley | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $333k | 0 |
| South Carolina Chiropractic Association | Columbia | — | $333k | 0 |
| JAMES F BYRNES FOUNDATION | Columbia | — | $333k | 0 |
| CATAWBA AREA COALITION FOR THE | Rock Hill | L01 Housing & Shelter | $333k | 0 |
| FRIENDS OF THE AIKEN RAILROAD DEPOT | Aiken | A57 Arts, Culture & Humanities | $333k | 0 |
| MARY SUNSHINE HOUSE | York | L21 Housing & Shelter | $333k | 1 |
| Auxiliary to Greenville Health System | Greenville | T30 Philanthropy, Voluntarism & Grantmaking Foundations | $333k | 2 |
| TRI-VISION HOUSING CORPORATION | Columbia | — | $333k | 0 |
| South Carolina Cancer Alliance | Columbia | — | $332k | 2 |
| MIDLANDS MECHANICAL APPRENTICE COAL | Columbia | J22 Employment | $332k | 1 |
| SOUTH CAROLINA ASSOCIATION OF | Columbia | S03 Community Improvement & Capacity Building | $332k | 0 |
| SUSTAINING WAY | Greenville | S20 Community Improvement & Capacity Building | $332k | 1 |
| BRICK EDUCATION AND RESEARCH | Anderson | B90 Education | $332k | 0 |
| CHAPIN ACADEMY | Prosperity | B20 Education | $332k | 3 |
| DAVID MCDONALD MINISTRIES | Summerville | X20 Religion-Related | $332k | 2 |
| CLARENDON CNTY CHAMBER OF COMMERCE | Manning | — | $332k | 0 |
| LOVABLE PAWS RESCUE | Ridgeland | D99 Animal-Related | $331k | 0 |
| Folds of Honor Palmetto State Chapter | Simpsonville | B12 Education | $331k | 0 |
| VINE AND BRANCHES HOMESCHOOL E | Myrtle Beach | B99 Education | $330k | 0 |
| LUCY HAMPTON BOSTICK CHARITABLE | Columbia | — | $330k | 0 |
| SEA ISLAND YACHT CLUB | Wadmalaw Island | N50 Recreation & Sports | $330k | 0 |
| SCHOOL TIME BIBLE MINISTRIES | Columbia | X11 Religion-Related | $330k | 0 |
| SOAR COLUMBIA | Columbia | X20 Religion-Related | $330k | 0 |
| THE HOMELESS PERIOD PROJECT INC | Greenville | P60 Human Services | $329k | 0 |
| SOUTH CAROLINA AVIATION ASSOCIATION | Charleston | — | $329k | 0 |
| LOWCOUNTRY YOUTH SERVICES | North Charleston | L40 Housing & Shelter | $329k | 0 |
| ORANGEBURG HOUSING INC | Orangeburg | P73Z Human Services | $329k | 0 |
| ECONOMIC OPPORTUNITY CENTER | North Charleston | P20 Human Services | $328k | 0 |
| HELPING FLORENCE FLOURISH | Florence | S80 Community Improvement & Capacity Building | $328k | 1 |
| SC City and County Management Assoc | Charleston | — | $328k | 0 |
| NAMI Piedmont Tri-County | Rock Hill | F01 Mental Health & Crisis Intervention | $328k | 3 |
| THE RECING CREW | North Augusta | N72 Recreation & Sports | $328k | 0 |
| FUTURE GENERATION INTERNATIONAL | Cowpens | Q33 International, Foreign Affairs & National Security | $327k | 1 |
| South Carolina Restaurant & Lodging | Columbia | B99 Education | $327k | 1 |
| MERE CHRISTIANITY FORUM INC | Travelers Rest | X20 Religion-Related | $327k | 0 |
| Trinity Educational Community Center | Columbia | P28 Human Services | $326k | 2 |
| CCU STUDENT HOUSING FOUNDATION | Conway | L80 Housing & Shelter | $326k | 1 |
| ORDER OF THE EASTERN STAR | Charleston | — | $326k | 2 |
| GREATER BLYTHEWOOD CHAMBER OF COMMERCE | Blythewood | S41 Community Improvement & Capacity Building | $325k | 1 |
