| A&T CARE | Kershaw | E92 Health Care | $2.5M | 0 |
| SCAGO EFC BEAUFORT COUNTY SCHOOL DISTRICT | Beaufort | B11 Education | $2.5M | 2 |
| FALL FOR GREENVILLE INC | Greenville | N52Z Recreation & Sports | $2.5M | 0 |
| Vital Connections of the Midlands | Columbia | P33 Human Services | $2.5M | 1 |
| CLARENDON FACILITIES CORPORATION | Manning | W20 Public & Societal Benefit | $2.5M | 0 |
| GREENVILLE RE-DEVELOPMENT CORPORATION | Greenville | L20 Housing & Shelter | $2.5M | 0 |
| VERITAS PREPARATORY SCHOOL INC | Greenville | B99 Education | $2.5M | 1 |
| THE NORTH EASTERN STRATEGIC ALLIANCEINC | Florence | S30 Community Improvement & Capacity Building | $2.5M | 1 |
| SC Educational Communications Inc | Spartanburg | A320 Arts, Culture & Humanities | $2.5M | 2 |
| HUMANE SOCIETY FOR THE PREVENTION OF CRUELTY TO ANIMALS | Columbia | D200 Animal-Related | $2.5M | 2 |
| Tamassee DAR School Inc | Tamassee | — | $2.5M | 1 |
| DORCHESTER SENIORS INC | Summerville | P810 Human Services | $2.5M | 2 |
| THE CHURCH MOUSE THRIFT SHOP INC | Hilton Head Island | S12 Community Improvement & Capacity Building | $2.5M | 0 |
| Charleston Library Society | Charleston | — | $2.5M | 1 |
| LANCASTER COUNTY FIRST STEPS TO SCHOOL READINESS PARTNERSHIP | Greenwood | B012 Education | $2.5M | 1 |
| Medal Of Honor Foundation Inc | Mount Pleasant | A118 Arts, Culture & Humanities | $2.5M | 1 |
| Tender Hearts Girls Home Inc | York | P73 Human Services | $2.5M | 1 |
| SPINKS FAMILY FOUNDATION | Greenville | T99 Philanthropy, Voluntarism & Grantmaking Foundations | $2.5M | 0 |
| LOWCOUNTRY DAY SCHOOL INC LOWCOUNTRY PREPARATORY SCHOOL | Pawleys Island | B24Z Education | $2.5M | 1 |
| Sowing Circle | Greenville | X20M Religion-Related | $2.5M | 4 |
| MONTESSORI SCHOOL OF ANDERSON | Anderson | B21Z Education | $2.5M | 2 |
| EPISCOPAL HOUSING CORPORATION | Columbia | — | $2.5M | 1 |
| MARY BLACK FOUNDATION INC | Spartanburg | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $2.5M | 2 |
| BIG RED BARN RETREAT | Blythewood | P80 Human Services | $2.5M | 0 |
| INDIAN WATERS COUNCIL BOY SCOUTS OF AMERICA INC | Columbia | O410 Youth Development | $2.5M | 1 |
| CAPE ROMAIN ENVIRONMENTAL EDUCATION CHARTER SCHOOL | McClellanville | B29 Education | $2.4M | 1 |
| PET HELPERS INC | Charleston | D200 Animal-Related | $2.4M | 1 |
| Presbyterian College Real Estate Foundation | Clinton | B42I Education | $2.4M | 0 |
| WALNUT GROVE CHRISTIAN SCHOOL | Fort Mill | B21 Education | $2.4M | 1 |
| SOUTH CAROLINA MANUFACTURERS ALLIANCE | Columbia | — | $2.4M | 3 |
| CITY OF FLORENCE PUBLIC FACILITIES CORPORATION | Florence | S02 Community Improvement & Capacity Building | $2.4M | 0 |
| ASSOCIATION FOR THE BLIND AND VISUALLY IMPAIRED SOUTH CAROLINA | Charleston | — | $2.4M | 1 |
| HILTON HEAD SYMPHONY ORCHESTRA INC | Hilton Head Island | A690 Arts, Culture & Humanities | $2.4M | 1 |
| CHARLESTON DIGITAL CORRIDOR FOUNDATION | Charleston | S41 Community Improvement & Capacity Building | $2.4M | 0 |
| Chickasaw Association Inc | Westminster | — | $2.4M | 0 |
| Oakland Club | Pineville | — | $2.4M | 0 |
| DARKNESS TO LIGHT INC | Mt Pleasant | I72 Crime & Legal-Related | $2.4M | 1 |
| LIVEWELL GREENVILLE | Greenville | O50 Youth Development | $2.4M | 1 |
| NATIONAL CHRISTIAN COLLEGE ATHLETIC ASSOCIATION | Greenville | B40C Education | $2.4M | 0 |
| The Movement Foundation Inc | Fort Mill | T31 Philanthropy, Voluntarism & Grantmaking Foundations | $2.4M | 4 |
| Community Development And Improvement Corporation | Graniteville | L21 Housing & Shelter | $2.4M | 1 |
| NORTH FLINT REINVESTMENT | Columbia | P20 Human Services | $2.4M | 1 |
| FRONTLINE MISSIONS INTERNATIONAL | Taylors | X21 Religion-Related | $2.4M | 1 |
| SC Vocations and Individual Advancement | Greenville | J20 Employment | $2.4M | 2 |
| CONWAY HOSPITAL COMMUNITY SERVICES | Conway | E30 Health Care | $2.4M | 6 |
| MERCY MEDICAL FREE CLINICS | Florence | E30 Health Care | $2.4M | 1 |
| APRIL 30TH FOUNDATION | Hilton Head Island | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $2.4M | 0 |
| SOUTH CAROLINA FARM BUREAU LAND TRUST INC | Cayce | K25 Food, Agriculture & Nutrition | $2.4M | 3 |
| SOUTH CAROLINA ASSOCIATION OF CERTIFIED PUBLIC ACCOUNTANTS INC | Cayce | — | $2.4M | 2 |
| The Rebecca C Parsons Foundation | Pawleys Island | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $2.4M | 3 |
