| Gullah Geechee Chamber Foundation | Georgetown | P20 Human Services | $457k | 0 |
| HOPE REMAINS YOUTH RANCH INC | Wellford | O50 Youth Development | $457k | 0 |
| GREGG-GRANITEVILLE FOUNDATION INC | Graniteville | — | $456k | 1 |
| NATIVE ISLAND BUSINESS & COMMUNITY | Hilton Head Island | S30 Community Improvement & Capacity Building | $456k | 0 |
| NEW BEGINNING OF CHARLESTON INC | Summerville | F99 Mental Health & Crisis Intervention | $456k | 3 |
| SOUTH CAROLINA FIRST STEPS TO | Greenwood | B122 Education | $455k | 1 |
| NAVIGATING FROM GOOD TO GREAT FOUNDATION | Columbia | S20 Community Improvement & Capacity Building | $454k | 1 |
| Cypress Adventures Inc | Hartsville | P33 Human Services | $454k | 1 |
| AMERICAN LEGION FRANK ROACH POST 34 | Rock Hill | — | $454k | 0 |
| EVERYBLACKGIRL INC | Columbia | B29 Education | $453k | 1 |
| UNIVERSAL COMMUNITY IMPROVEMENT ORGANIZATION | Irmo | P20 Human Services | $453k | 0 |
| TRI-CITY VISIONARIES INC | Eastover | P20 Human Services | $453k | 0 |
| W C CHRISTIAN CHILD | Summerville | P33 Human Services | $453k | 2 |
| FOUNDATION FOR COMMUNITY IMPACT & HEALTH EQUITY | Ridgeway | E70 Health Care | $452k | 2 |
| BLACK RIVER UNITED WAY INC | Georgetown | T70Z Philanthropy, Voluntarism & Grantmaking Foundations | $452k | 1 |
| TECHNICAL COLLEGE OF THE LOWCOUNTRY | Beaufort | B41I Education | $452k | 0 |
| JOHNSON FAMILY FOUNDATION INC | Simpsonville | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $451k | 0 |
| NATIONAL POSTAL MAIL HANDLERS UNION | West Columbia | — | $451k | 8 |
| SHALOM HOUSE MINISTRIES INC | Belton | F20 Mental Health & Crisis Intervention | $451k | 1 |
| ORANGEBURG COUNTY FAIR ASSOCIATION | Orangeburg | — | $451k | 0 |
| FAST FORWARD | Columbia | P20 Human Services | $451k | 1 |
| FAMILY PROMISE OF YORK COUNTYINC | Rock Hill | P85 Human Services | $451k | 1 |
| SOUTH CAROLINA FIRST STEPS TO | Greenwood | B012 Education | $450k | 0 |
| MSPGEEK INC | Taylors | S40 Community Improvement & Capacity Building | $450k | 0 |
| LCA FOUNDATION | Ridgeland | B90 Education | $450k | 0 |
| Palmetto Recovery of Charleston | Charleston | F20 Mental Health & Crisis Intervention | $450k | 2 |
| SOUTH CAROLINA WORKERS' | Columbia | B60 Education | $449k | 0 |
| Come-See-Me Festival Inc | Rock Hill | W99 Public & Societal Benefit | $449k | 0 |
| Sea Island Hunger Awareness Foundation | Johns Island | K30 Food, Agriculture & Nutrition | $449k | 0 |
| HELPING HANDS OF GOOSE CREEK INC | Goose Creek | — | $448k | 1 |
| Spartanburg United Soccer Academy | Boiling Springs | N60 Recreation & Sports | $448k | 1 |
| REBEL BAND BOOSTER CLUB | Duncan | A11 Arts, Culture & Humanities | $448k | 0 |
| DIXIE HIGH SCHOOL FOUNDATION INC | Due West | B94 Education | $448k | 0 |
| PALMETTO ANIMAL ASSISTED LIFE SERVI | Columbia | P80 Human Services | $448k | 0 |
| CERTIFIED DEVELOPMENT CORPORATION | Columbia | S31Z Community Improvement & Capacity Building | $447k | 13 |
| HABITAT FOR HUMANITY INTERNATIONAL | Camden | — | $447k | 0 |
| AIKEN SYMPHONY ORCHESTRA | Aiken | A69 Arts, Culture & Humanities | $446k | 1 |
| SCHOOL NUTRITION ASSOCIATION OF SC | Columbia | — | $446k | 0 |
| UPSTATE INSTITUTE OF YOUTH PROGRAMS | Seneca | O50 Youth Development | $446k | 3 |
| CHARLESTON SYMPHONY ORCHESTRA LEAGUE INC | Charleston | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $446k | 0 |
| CHEROKEE CREEK VOLUNTEER FIRE DEPARTMENT INC | Gaffney | M24Z Public Safety, Disaster Preparedness & Relief | $446k | 0 |
| HELP OF BEAUFORT | Beaufort | P600 Human Services | $446k | 1 |
| THE VISION INSTITUTE OF SOUTH CAROLINA I | Irmo | — | $446k | 0 |
| Foundation for Reproductive Genetics Education Inc | Irmo | B90 Education | $445k | 0 |
| Pursuit Christian Academy | Effingham | — | $445k | 0 |
| PALMETTO BASEBALL LEAGUE INC | Columbia | N63Z Recreation & Sports | $444k | 0 |
| Fletcher Gwaltney Shared Services Inc | Bamberg | E92Z Health Care | $444k | 0 |
| THE HAVEN MEN'S SHELTER | Rock Hill | L41 Housing & Shelter | $444k | 0 |
| Coastal Samaritan Counseling Center | Myrtle Beach | P46Z Human Services | $444k | 2 |
| WASHINGTON LIGHT INFANTRY OF CHARLESTON INC | Charleston | — | $443k | 4 |
