| OVERFLOW FOUNDATION INC | Aiken | F40 Mental Health & Crisis Intervention | $476k | 1 |
| FRED COLLINS FOUNDATION | Simpsonville | — | $476k | 0 |
| AMERICAN ACADEMY OF FAMILY PHYSICIANS SC CHAPTER | Laurens | — | $475k | 1 |
| FLORENCE SOCCER ASSOCIATION | Florence | N64Z Recreation & Sports | $474k | 0 |
| AMERICAN LEGION AUXILARY OF SC | Columbia | — | $474k | 2 |
| RECRAFT CREATIVE REUSE CENTER | Greenville | C27 Environment | $472k | 1 |
| Legacy Baseball | Fort Mill | N63 Recreation & Sports | $472k | 0 |
| GREENVILLE HIGH RED RAIDER SPORTS BOOSTER CLUB INC | Greenville | B112 Education | $472k | 0 |
| MARLBORO COUNTY GENERAL HOSPITAL | Bennettsville | — | $472k | 0 |
| COLUMBIA CHILDRENS THEATRE | Columbia | A65 Arts, Culture & Humanities | $472k | 0 |
| HOSPICE CARE FOUNDATION OF THE | Greenwood | E11 Health Care | $472k | 0 |
| OCEAN VIEW MEMORIAL FOUNDATION INC | Myrtle Beach | T31 Philanthropy, Voluntarism & Grantmaking Foundations | $472k | 0 |
| STRONGER THAN EVER | Fort Mill | Q33 International, Foreign Affairs & National Security | $471k | 0 |
| CATAWBA REGIONAL DEVELOPMENT | Rock Hill | — | $471k | 0 |
| BETHEL CHRISTIAN CAMP AND RETREAT C | Gaston | — | $471k | 0 |
| TRI-COUNTY COMMUNITY FOUNDATION | Barnwell | T31 Philanthropy, Voluntarism & Grantmaking Foundations | $471k | 1 |
| UNITED WAY OF LANCASTER COUNTY INC | Lancaster | T70Z Philanthropy, Voluntarism & Grantmaking Foundations | $470k | 0 |
| THE BERKELEY HALL CHARITABLE | Bluffton | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $470k | 0 |
| THE LIVITY FOUNDATION INC | Charleston | T30 Philanthropy, Voluntarism & Grantmaking Foundations | $469k | 1 |
| VETERANS OF FOREIGN WARS POST 4262 | Columbia | W30 Public & Societal Benefit | $469k | 0 |
| South Carolina Beverage Association Inc | Columbia | — | $469k | 1 |
| VETERANS OF FOREIGN WARS OF THE | Isle Of Palms | — | $467k | 0 |
| CECIL WILLAMS SOUTH CAROLINA CIVIL RIGHTS MUSEUM | Orangeburg | V31 Social Science | $467k | 0 |
| Coles Victory Lap | Greenville | E86 Health Care | $467k | 0 |
| TOTAL MINISTRIES | Spartanburg | — | $467k | 1 |
| TOTT SOCIAL CLUB | Clemson | — | $466k | 0 |
| SOUTH CAROLINA FUTURE FARMERS OF AMERICA FOUNDATION | Saluda | — | $466k | 1 |
| ROCK INTERNATIONAL | Greenville | X21 Religion-Related | $466k | 0 |
| PALMETTO GUN CLUB INC | Summerville | — | $466k | 0 |
| CONGAREE LAND TRUST | Columbia | C340 Environment | $465k | 1 |
| S C HUNTERS AND LANDOWNERS FOR THE HUNGRY | Spartanburg | P40 Human Services | $463k | 0 |
| FOR INSPIRATION RECOGNITION OF SCIENCE | Ridgeville | O50 Youth Development | $462k | 0 |
| THE BARBARA STONE FOUNDATION | Greenville | F30I Mental Health & Crisis Intervention | $461k | 0 |
| IMPACT SPORTS INTERNATIONAL | Spartanburg | X99 Religion-Related | $461k | 1 |
| CLARENCE H & ANNA E LUTZ FOUNDATION | Chester | — | $460k | 3 |
| DORN RESEARCH INSTITUTE INC | Columbia | H99Z Medical Research | $460k | 2 |
| SOUTH CAROLINA MIDLANDS EMERGENCY | West Columbia | — | $460k | 1 |
| C4 MINISTRIES INC | Union | X20 Religion-Related | $460k | 3 |
| PEE DEE HEARING CENTER | Florence | — | $460k | 3 |
| RUTH'S GLEANINGS | Spartanburg | P80 Human Services | $459k | 5 |
| SUMMERVILLE ORCHESTRA | Summerville | A69 Arts, Culture & Humanities | $459k | 0 |
| NORMAN J AND GERRY SUE ARNOLD | Columbia | T90Z Philanthropy, Voluntarism & Grantmaking Foundations | $459k | 3 |
| CORNERSTONE CHRISTIAN SCHOOL | Camden | B20 Education | $459k | 0 |
| ORCHARD HOUSE CLUB INC | Sunset | N50 Recreation & Sports | $459k | 0 |
| SOUTH CAROLINA ASSOCIATION | Columbia | — | $458k | 2 |
| PROGRESSIVE FAMILY LIFE CENTER | Denmark | P33 Human Services | $458k | 0 |
| SIOP FOUNDATION INC | Drayton | B82 Education | $458k | 0 |
| SECOND CHANCE SHOP | Summerville | P29 Human Services | $458k | 0 |
| SOUTH CAROLINA HUMAN SERVICES PROVIDERS INC | Winnsboro | S41 Community Improvement & Capacity Building | $458k | 0 |
| Conway Downtown Alive Inc | Conway | S200 Community Improvement & Capacity Building | $457k | 1 |
