| THE DREAM CENTER OF PICKENS COUNTY | Easley | P85 Human Services | $3.8M | 1 |
| CHILDREN'S PLACE INC | Aiken | — | $3.8M | 0 |
| METANOIA | North Charleston | S31 Community Improvement & Capacity Building | $3.8M | 2 |
| LAKES AND BRIDGES CHARTER SCHOOL INC | Easley | B29 Education | $3.8M | 0 |
| CHILDREN'S MUSEUM OF THE UPSTATE INC | Greenville | A520 Arts, Culture & Humanities | $3.8M | 0 |
| Edventure Inc | Columbia | A520 Arts, Culture & Humanities | $3.8M | 2 |
| The Charleston Museum | Charleston | A540 Arts, Culture & Humanities | $3.8M | 1 |
| The Country Club of Lexington | Lexington | — | $3.8M | 0 |
| PETER B AND ADELINE W RUFFIN FOUNDATION INC | Johns Island | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $3.7M | 1 |
| CHARLESTON CHAMBER FOUNDATION | North Charleston | S114 Community Improvement & Capacity Building | $3.7M | 1 |
| SUMTER MUSEUM | Sumter | A540 Arts, Culture & Humanities | $3.7M | 0 |
| COLUMBIA COUNTRY CLUB | Blythewood | — | $3.7M | 0 |
| SEA ISLAND HABITAT FOR HUMANITY INC | Johns Island | — | $3.7M | 2 |
| The Cooper School | Charleston | B24 Education | $3.7M | 2 |
| MIDLANDS STEM CHARTER SCHOOL | Winnsboro | B29 Education | $3.6M | 1 |
| LOWCOUNTRY CENTER FOR VETERANS RESEARCH | Charleston | H05 Medical Research | $3.6M | 8 |
| VALLEY HILL FIRE & RESCUE DEPARTMENT INC | Travelers Rest | — | $3.6M | 0 |
| Easter Seal Society of South Carolina | Columbia | — | $3.6M | 6 |
| FRIENDS OF CAROLINE HOSPICE OF BEAU | Ridgeland | — | $3.6M | 0 |
| METROPOLITAN ARTS COUNCIL | Greenville | — | $3.6M | 1 |
| CHARLESTON METRO CHAMBER OF COMMERCE | North Charleston | — | $3.6M | 8 |
| PALMETTO ACHIEVEMENT CENTER FOR EXCELLENCE ACADEMY INC | Columbia | B29 Education | $3.6M | 0 |
| GREENVILLE SYMPHONY ASSOCIATION | Greenville | A690 Arts, Culture & Humanities | $3.6M | 1 |
| Carolina Crown INC | Fort Mill | — | $3.6M | 1 |
| NATIONAL ASSOCIATION FOR CAMPUS ACTIVITIES | Columbia | — | $3.6M | 3 |
| Camp Canaan | Rock Hill | O43 Youth Development | $3.6M | 0 |
| WHITESVILLE RURAL FIRE DEPARTMENT DBA CENTRAL BERKELEY FIRE & EMS | Summerville | M24 Public Safety, Disaster Preparedness & Relief | $3.6M | 0 |
| UNITED MINISTRIES | Greenville | X21Z Religion-Related | $3.6M | 1 |
| FRONT PORCH HOUSING | Greenville | L21 Housing & Shelter | $3.6M | 0 |
| Boys and Girls Clubs of the Crescent Region | Columbia | — | $3.6M | 1 |
| STAR GOSPEL MISSION | Mount Pleasant | — | $3.6M | 1 |
| ANDERSON FREE CLINIC | Anderson | E32Z Health Care | $3.6M | 1 |
| MOBILE MEALS OF SPARTANBURG COUNTY INC | Spartanburg | K36Z Food, Agriculture & Nutrition | $3.6M | 2 |
| Palmetto Care Connections | Bamberg | E99 Health Care | $3.6M | 4 |
| NATIONAL GOLF COURSE OWNERS ASSOCIATION | Charleston | — | $3.5M | 3 |
| SANTEE LYNCHES AFFORDABLE HOUSING AND COMMUNITY DEVELOPMENT CORPORAT | Sumter | L21Z Housing & Shelter | $3.5M | 0 |
| PIEDMONT CARE INC | Spartanburg | E80 Health Care | $3.5M | 1 |
| Clapham Education Group | North Charleston | B24 Education | $3.5M | 1 |
| GARNET TRUST FOUNDATION | Columbia | T50 Philanthropy, Voluntarism & Grantmaking Foundations | $3.5M | 0 |
| CHARLESTON STAGE COMPANY INC | Charleston | A650 Arts, Culture & Humanities | $3.5M | 3 |
| HILTON HEAD HUMANE ASSOCIATION | Hilton Head Island | D200 Animal-Related | $3.5M | 1 |
| THE UNIVERSITY CENTER OF GREENVILLE | Greenville | B82 Education | $3.5M | 2 |
| CHESTER FACILITIES CORPORATION | Chester | S99 Community Improvement & Capacity Building | $3.5M | 0 |
| ADDLESTONE HEBREW ACADEMY | Charleston | B24 Education | $3.5M | 1 |
| MARCO RURAL WATER CO INC | Marion | — | $3.5M | 10 |
| THE ACADEMY FOR TEACHING & LEARNING OF THE CHESTER COUNTY SCHOOL DIST | Chester | B29 Education | $3.5M | 2 |
| Project MedSend | Fort Mill | B82 Education | $3.4M | 3 |
| PAYMENTSFIRST INC | Columbia | — | $3.4M | 5 |
| YORK COUNTY COUNCIL ON AGING INC | Rock Hill | P81Z Human Services | $3.4M | 1 |
| A CHILD'S HAVEN INC | Greenville | — | $3.4M | 1 |
