| PALMETTO ECONOMIC DEVELOPMENT CORP DBA SOUTH CAROLINA POWER TEAM | Columbia | — | $4.1M | 21 |
| SISTERCARE INC | Columbia | — | $4.1M | 1 |
| UNITED WAY OF KERSHAW COUNTY | Camden | — | $4.1M | 1 |
| JUMPSTART SOUTH CAROLINA | Spartanburg | I40 Crime & Legal-Related | $4.1M | 2 |
| Vision Center | Columbia | X99 Religion-Related | $4.1M | 0 |
| SOUTH CAROLINA EDUCATION FUTURES | Columbia | B29 Education | $4.1M | 1 |
| BLUE LETTER BIBLE | Greenville | — | $4.1M | 7 |
| Naturaland Trust | Greenville | C340 Environment | $4.1M | 2 |
| HILTON HEAD ISLAND RECREATION | Hilton Head Island | — | $4.1M | 1 |
| SOUTH CAROLINA ASSOCIATION FOR COMMUNITY ECONOMIC DEVELOPMENT | Charleston | S31 Community Improvement & Capacity Building | $4.1M | 2 |
| SANDHILLS SCHOOL | Columbia | — | $4.1M | 1 |
| THE MARIA AND STEVEN MUNGO FOUNDATION | Charleston | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $4.1M | 0 |
| SCHA Foundation Inc | Columbia | — | $4.1M | 1 |
| BCD Rural Transportation | Moncks Corner | — | $4.1M | 0 |
| SOUTH CAROLINA ASSOCIATION OF SCHOOL ADMINISTRATORS | Columbia | — | $4.1M | 4 |
| NORTH MYRTLE BEACH CHAMBER OF COMMERCE CONVENTION AND VISTOR'S BU | North Myrtle Beach | S41 Community Improvement & Capacity Building | $4.1M | 1 |
| WO AND ANN POWERS FOUNDATION INC | Florence | T90Z Philanthropy, Voluntarism & Grantmaking Foundations | $4M | 12 |
| COLUMBIA UNITED FC DBA SOUTH CAROLINA UNITED FC | Columbia | — | $4M | 1 |
| SOUTH CAROLINA STATE FIREFIGHTERS' ASSOCIATION | Columbia | — | $4M | 1 |
| UPSTATE WARRIOR SOLUTION INC | Greenville | P60 Human Services | $4M | 1 |
| KATIE AND IRWIN KAHN JEWISH COMMUNITY CENTER | Columbia | P33Z Human Services | $4M | 0 |
| RICHLAND COUNTY FIRST STEPS TO SCHOOL READINESS PARTNERSHIP | Greenwood | B012 Education | $4M | 1 |
| DANNY & RONS RESCUE | Rembert | D20 Animal-Related | $4M | 0 |
| Roper St Francis Ancillary Services | Ladson | E60 Health Care | $4M | 6 |
| Darlington County Humane Society Inc | Hartsville | D200 Animal-Related | $4M | 0 |
| UPSTATE FOREVER | Greenville | C013 Environment | $4M | 4 |
| LAKE CITY CREATIVE ALLIANCE | Lake City | A20 Arts, Culture & Humanities | $4M | 1 |
| JEWISH ENDOWMENT FOUNDATION OF SOUTH CAROLINA | N Charleston | T22Z Philanthropy, Voluntarism & Grantmaking Foundations | $4M | 2 |
| COASTAL EDUCATIONAL FOUNDATION | Conway | — | $4M | 0 |
| Plumbers & Pipefitters LU 421 Training Fund | North Charleston | B30 Education | $3.9M | 1 |
| ABNEY FOUNDATION | Anderson | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $3.9M | 6 |
| BLUFFTON SELF HELP INC | Bluffton | — | $3.9M | 2 |
| GREATER GREENVILLE CHAMBER OF COMMERCE | Greenville | — | $3.9M | 5 |
| THE ERNEST E KENNEDY CENTER INC | Moncks Corner | F50Z Mental Health & Crisis Intervention | $3.9M | 1 |
| HORRY COUNTY COUNCIL ON AGING INC | Conway | — | $3.9M | 2 |
| HARVESTERS MINISTRIES | Fort Mill | X20 Religion-Related | $3.9M | 2 |
| CHAPIN FOUNDATION OF MYRTLE BEACH SC | Myrtle Beach | — | $3.9M | 1 |
| HOPE CENTER FOR CHILDREN | Spartanburg | — | $3.9M | 1 |
| FRIENDSHIP MEDICAL CLINIC INC | Conway | E210 Health Care | $3.9M | 0 |
| SOUTH CAROLINA NETWORK OF CHILDREN'S ADVOCACY CENTERS | Columbia | O02 Youth Development | $3.9M | 1 |
| Southeastern Chapter National Safety Council | Irmo | — | $3.9M | 1 |
| SRS COMMUNITY REUSE ORGANIZATION INC | Aiken | S30 Community Improvement & Capacity Building | $3.9M | 2 |
| BEEMOK FAMILY FOUNDATION | Charleston | B82 Education | $3.9M | 0 |
| GLOBAL ACADEMY OF SOUTH CAROLINA | Spartanburg | — | $3.9M | 0 |
| CHILDREN'S ATTENTION HOME INC | Rock Hill | — | $3.9M | 2 |
| The Charleston Parks Conservancy | Charleston | C42 Environment | $3.8M | 1 |
| THE TURTLE SURVIVAL ALLIANCE FOUNDATION | North Charleston | D30 Animal-Related | $3.8M | 2 |
| YOUTH LEADERSHIP ACADEMY | Pickens | B29 Education | $3.8M | 0 |
| KAY PHILLIPS CHILD ADVOCACY CENTER INC | Summerville | P32 Human Services | $3.8M | 1 |
| The Lancaster County Partners for Youth | Lancaster | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $3.8M | 1 |
