| Natrona County Meals on Wheels Inc | Casper | P81Z Human Services | $2.7M | 1 |
| FREMONT COUNSELING SERVICE INC | Lander | F32Z Mental Health & Crisis Intervention | $2.7M | 2 |
| FRONTIER SCHOOL OF THE BIBLE | LaGrange | B41Z Education | $2.7M | 1 |
| EBOR CHARITABLE TRUST | Jackson | P99 Human Services | $2.6M | 1 |
| JACKSON HOLE CHAMBER OF COMMERCE | Jackson | — | $2.6M | 1 |
| Wyoming Independent Living Inc | Casper | P8XZ Human Services | $2.5M | 0 |
| WYOMING SENIOR CITIZENS INC | Riverton | P81Z Human Services | $2.5M | 1 |
| Serve Wyoming Inc | Casper | T40 Philanthropy, Voluntarism & Grantmaking Foundations | $2.5M | 0 |
| LARAMIE PLAINS MUSEUM ASSOCIATION | Laramie | A540 Arts, Culture & Humanities | $2.5M | 0 |
| BLUELIGHT HEALS CORPORATION | Cheyenne | E70 Health Care | $2.5M | 7 |
| WOLD FOUNDATION | Casper | — | $2.5M | 0 |
| CHEYENNE REGIONAL MEDICAL CENTER | Cheyenne | E60 Health Care | $2.5M | 2 |
| VISION BEYOND BORDERS INC | Casper | X21 Religion-Related | $2.4M | 1 |
| Cloud Peak Counseling Center | Worland | F32Z Mental Health & Crisis Intervention | $2.4M | 1 |
| Teton County Search & Rescue Foundation | Jackson | M23 Public Safety, Disaster Preparedness & Relief | $2.4M | 1 |
| TETON RAPTOR CENTER | Wilson | — | $2.4M | 2 |
| WYOMING HOUSING NETWORK INC | Casper | L20 Housing & Shelter | $2.4M | 1 |
| BUFFALO SENIOR CENTER INC | Buffalo | — | $2.4M | 1 |
| TETON LITERACY CENTER | Jackson | B92Z Education | $2.4M | 1 |
| YOUNG AT HEART SENIOR CITIZENS CENTER | Rock Springs | P81Z Human Services | $2.4M | 1 |
| WYOMING HOSPITAL ASSOCIATION | Cheyenne | — | $2.4M | 3 |
| MARY H STORER FOUNDATION | Cheyenne | T21 Philanthropy, Voluntarism & Grantmaking Foundations | $2.4M | 5 |
| FOSTER'S OUTRIDERS FOUNDATION | Jackson | R60 Civil Rights, Social Action & Advocacy | $2.3M | 1 |
| CONVERSE COUNTY AGING SERVICES | Douglas | P81Z Human Services | $2.3M | 0 |
| THE KINDNESS RANCH ANIMAL SANCTUARY | Hartville | D20 Animal-Related | $2.3M | 3 |
| DIVERSIFIED SERVICES INC | Torrington | J30Z Employment | $2.3M | 1 |
| HEART MOUNTAIN WYOMING FOUNDATION | Powell | A80 Arts, Culture & Humanities | $2.3M | 0 |
| WYOMING SCHOOL BOARDS ASSOCIATION | Cheyenne | — | $2.2M | 4 |
| DOG IS MY COPILOT | Jackson | D20 Animal-Related | $2.2M | 1 |
| STAR VALLEY RANCH ASSOCIATION | Star Valley Ranch | — | $2.2M | 1 |
| AMERICAN CHAMBER OF COMMERCE IN UKRAINE INC | Cody | S41 Community Improvement & Capacity Building | $2.2M | 1 |
| CAMPBELL COUNTY SENIOR CITIZENS | Gillette | P81 Human Services | $2.1M | 1 |
| HABITAT FOR HUMANITY OF THE GREATER | Jackson | — | $2.1M | 1 |
| KARL M JOHNSON FOUNDATION | Jackson | — | $2.1M | 3 |
| Northern Wyoming Community College | Sheridan | B112 Education | $2.1M | 2 |
| YELLOWSTONE BEHAVIORAL HEALTH | Cody | — | $2.1M | 1 |
| UCROSS FOUNDATION | Clearmont | T30 Philanthropy, Voluntarism & Grantmaking Foundations | $2M | 1 |
| DANCERS WORKSHOP | Jackson | A6E0 Arts, Culture & Humanities | $2M | 1 |
| THE INSTITUTE FOR ETHNOMEDICINE INC | Jackson | H99 Medical Research | $2M | 4 |
| UINTA SENIOR CITIZENS INC | Evanston | — | $2M | 0 |
| HOSPICE OF LARAMIE | Laramie | — | $2M | 0 |
| Astoria Park Conservancy | Jackson | C34 Environment | $1.9M | 2 |
| Pamela and Wayne Garrison Family Foundation | Big Horn | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $1.9M | 1 |
| RIVERTON MEDICAL DISTRICT | Riverton | E32 Health Care | $1.9M | 0 |
| WYOMING SERVICES FOR INDEPENDENT LIVING | Lander | E91 Health Care | $1.9M | 0 |
| MERCATOR CHARITABLE TRUST | Jackson | A20 Arts, Culture & Humanities | $1.9M | 1 |
| RURAL DEVELOPMENT FUND | Casper | S31 Community Improvement & Capacity Building | $1.9M | 0 |
| SNAKE RIVER FUND | Jackson | C32 Environment | $1.9M | 0 |
| THE LILLIAN SHERWOOD | Lander | T20J Philanthropy, Voluntarism & Grantmaking Foundations | $1.9M | 0 |
| LIANA FOUNDATION INC | Jackson | T21 Philanthropy, Voluntarism & Grantmaking Foundations | $1.9M | 0 |
