| AMERICA NEXT | Baton Rouge | E99 Health Care | $5.1M | 1 |
| HEALTH CARE CENTERS IN SCHOOLS | Baton Rouge | E30 Health Care | $5.1M | 9 |
| United Way of Southwest Louisiana Inc | Lake Charles | — | $5.1M | 2 |
| SILLIMAN INSTITUTE INC | Clinton | B20 Education | $5M | 0 |
| HORSEMEN'S WORKERS' COMPENSATION INSURANCE TRUST | New Orleans | Y25 Mutual & Membership Benefit | $5M | 1 |
| NEW ORLEANS CAREER CENTER | New Orleans | B30 Education | $5M | 1 |
| GOOD SHEPHERD NATIVITY MISSION SCHOOL INC | New Orleans | B24 Education | $5M | 1 |
| Slaughter Community Charter School | Slaughter | B29 Education | $5M | 1 |
| BATON ROUGE COMMUNITY COLLEGE FOUNDATION | Baton Rouge | T11 Philanthropy, Voluntarism & Grantmaking Foundations | $5M | 0 |
| NOAHH SO INC | New Orleans | P11 Human Services | $4.9M | 2 |
| GENERAL HEALTH SYSTEM FOUNDATION | Baton Rouge | — | $4.9M | 3 |
| LOUISIANA BUCKET BRIGADE | New Orleans | C99 Environment | $4.9M | 2 |
| THIRD DISTRICT VOLUNTEER FIRE DEPARTMENTS - BAYOU CHAPTER | River Ridge | M24Z Public Safety, Disaster Preparedness & Relief | $4.9M | 0 |
| YOUTHFORCE NOLA | New Orleans | B11 Education | $4.8M | 6 |
| BATON ROUGE AREA CHAMBER | Baton Rouge | — | $4.8M | 8 |
| GREATER NEW ORLEANS INC | New Orleans | — | $4.8M | 7 |
| REBUILDING TOGETHER NEW ORLEANS | New Orleans | T19 Philanthropy, Voluntarism & Grantmaking Foundations | $4.8M | 2 |
| CHILDREN'S CUP | Prairieville | X20 Religion-Related | $4.8M | 1 |
| LOUISIANA SHERIFFS ASSOCIATION | Baton Rouge | S41 Community Improvement & Capacity Building | $4.8M | 0 |
| Rapides Primary Health Care Center Inc | Alexandria | — | $4.8M | 4 |
| GEORGE HELEN AND HAROLD WAINER FOUNDAT FOUNDATION | Metairie | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $4.8M | 0 |
| CENTER FOR PLANNING EXCELLENCE | Baton Rouge | M20 Public Safety, Disaster Preparedness & Relief | $4.7M | 6 |
| INTERNATIONAL BROTHERHOOD OF ELECTRICAL WORKERS 995 HEALTH & WELFARE FUND | Baton Rouge | — | $4.7M | 1 |
| THE ARC OF OUACHITA | Monroe | P820 Human Services | $4.7M | 0 |
| OFFSHORE OPERATORS COMMITTEE | Kenner | — | $4.7M | 3 |
| ARLENE & JOSEPH MERAUX CHARITABLE FOUNDATION INC | Violet | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $4.7M | 4 |
| Oak Alley Foundation | Vacherie | — | $4.7M | 0 |
| BAYOU DESIARD COUNTRY CLUB INC | Monroe | — | $4.7M | 0 |
| MY RIGHT TO HEAR | Shreveport | Q33 International, Foreign Affairs & National Security | $4.7M | 0 |
| NEW ORLEANS SPONSORING COMMITTEE -TOGETHER NEW ORLEANS | New Orleans | S30 Community Improvement & Capacity Building | $4.7M | 0 |
| VIA LINK INC | Covington | — | $4.6M | 1 |
| Entergy Charitable Foundation | New Orleans | T21 Philanthropy, Voluntarism & Grantmaking Foundations | $4.6M | 0 |
| Women With A Vision | New Orleans | G81Z Diseases, Disorders & Medical Disciplines | $4.6M | 4 |
| NEW ORLEANS CULINARY & HOSPITALITY INSTITUTE | New Orleans | Z99 Unknown | $4.6M | 3 |
| JEWISH FEDERATION OF GREATER NEW ORLEANS | Metairie | T700 Philanthropy, Voluntarism & Grantmaking Foundations | $4.6M | 3 |
| THE PROMISE OF JUSTICE INITIATIVE | New Orleans | I80 Crime & Legal-Related | $4.6M | 1 |
| United Methodist Foundation of Louisiana Inc | Baton Rouge | T30 Philanthropy, Voluntarism & Grantmaking Foundations | $4.6M | 2 |
| KREWE OF IRIS 1917 | New Orleans | — | $4.6M | 0 |
| LOUISIANA CHILDRENS MUSEUM | New Orleans | A520 Arts, Culture & Humanities | $4.6M | 5 |
| United Cajun Navy | Baton Rouge | M20 Public Safety, Disaster Preparedness & Relief | $4.6M | 0 |
| JESUIT HIGH SCHOOL OF NEW ORLEANS FOUNDATION INC | New Orleans | B11 Education | $4.5M | 0 |
| CAMPUS FACILITIES INC | Bossier City | B99 Education | $4.5M | 0 |
| United Way of Acadiana Inc | Lafayette | T70 Philanthropy, Voluntarism & Grantmaking Foundations | $4.5M | 1 |
| HABITAT FOR HUMANITY ST TAMMANY WEST | Mandeville | — | $4.5M | 1 |
| THE HUEY & ANGELINA WILSON FOUNDATION | Baton Rouge | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $4.5M | 1 |
| KREWE OF TUCKS | New Orleans | — | $4.5M | 0 |
| LAFAYETTE HABITAT FOR HUMANITY INC | Lafayette | L20Z Housing & Shelter | $4.4M | 2 |
| Faith House Inc | Lafayette | P430 Human Services | $4.4M | 1 |
| HOME AWAY FROM HOME INC dba GOOD SAMARITAN LIVING CENTER | Franklinton | E91 Health Care | $4.4M | 0 |
| Zemurray Foundation | New Orleans | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $4.4M | 2 |
