| GOOD360 | Alexandria | VA | $3.1B | 10 |
| GAVI ALLIANCE | Grandsaconnex | — | $2.6B | 14 |
| DIRECT RELIEF | Santa Barbara | CA | $2.4B | 8 |
| AMERICARES FOUNDATION INC | Stamford | CT | $1.6B | 16 |
| INTERNATIONAL RESCUE COMMITTEE INC | New York | NY | $1.5B | 12 |
| World Vision Inc | Federal Way | WA | $1.5B | 14 |
| MAP International Inc | Brunswick | GA | $934.8M | 8 |
| Save The Children Federation Inc | Fairfield | CT | $920.5M | 25 |
| COOPERATIVE FOR ASSISTANCE AND RELIEF | Atlanta | GA | $909.1M | 18 |
| Family Health International Inc | Durham | NC | $800M | 31 |
| MEDECINS SANS FRONTIERES USA INC | New York | NY | $776.9M | 26 |
| PLAN INTERNATIONAL INC | New York | NY | $755.9M | 15 |
| UNITED STATES FUND FOR UNICEF | New York | NY | $720.4M | 14 |
| Mercy Corps | Portland | OR | $465.5M | 21 |
| THE ROTARY FOUNDATION OF ROTARY | Evanston | IL | $418.1M | 17 |
| FOOD FOR THE POOR INC | Coconut Creek | FL | $412.1M | 13 |
| HEART TO HEART INTERNATIONAL | Lenexa | KS | $410.1M | 4 |
| The American Jewish Joint Distribution | New York | NY | $409.8M | 13 |
| FEED THE CHILDREN INC | Oklahoma City | OK | $408.9M | 12 |
| INSTITUTE OF INTERNATIONAL EDUCATION INC | New York | NY | $395.5M | 11 |
| HABITAT FOR HUMANITY INTERNATIONAL INC | Americus | GA | $370M | 29 |
| PATH | Seattle | WA | $353.5M | 16 |
| WORLD CENTRAL KITCHEN INC | Washington | DC | $327.8M | 13 |
| CATHOLIC MEDICAL MISSION BOARD INC | Long Island City | NY | $324.3M | 7 |
| Matthew 25 Ministries Inc | Cincinnati | OH | $297.3M | 5 |
| Mercy Ships International | Lindale | TX | $287.1M | 15 |
| CHURCH WORLD SERVICE INC | Elkhart | IN | $283.8M | 6 |
| FRIENDS OF THE ISRAEL DEFENSE FORCES | New York | NY | $282M | 14 |
| WORLD RESOURCES INSTITUTE | Washington | DC | $267.4M | 17 |
| PROJECT ORBIS INTERNATIONAL INC | New York | NY | $259.9M | 11 |
| ONE ACRE FUND | Highland Park | IL | $248.2M | 11 |
| THE CARTER CENTER COLLABORATIVE INC | Atlanta | GA | $234.8M | 3 |
| CLINTON HEALTH ACCESS INITIATIVE INC | Boston | MA | $224.7M | 13 |
| Jewish National Fund | New York | NY | $224.3M | 10 |
| INTERNATIONAL MEDICAL CORPS | Los Angeles | CA | $220.3M | 8 |
| PURE HANDS INC | Plano | TX | $213.8M | 1 |
| Childfund International USA | Richmond | VA | $210.2M | 7 |
| AMERICAN NEAR EAST REFUGEE AID | Washington | DC | $204.3M | 9 |
| MYRIAD USA INC | New York | NY | $200.5M | 7 |
| WORLD RELIEF CORP OF NATIONAL | Towson | MD | $194.2M | 10 |
| CIEE Inc | South Portland | ME | $187.7M | 10 |
| PROJECT HOPE - THE PEOPLE-TO-PEOPLE | Washington | DC | $186.5M | 15 |
| CHILDREN'S HUNGER FUND | Rancho Cascades | CA | $183.8M | 7 |
| PACT INC | Washington | DC | $181.8M | 11 |
| NATIONAL DEMOCRATIC INSTITUTE FOR | Washington | DC | $181.5M | 15 |
| Food For The Hungry Inc | Phoenix | AZ | $180.2M | 7 |
| GLOBAL COMMUNITIES | Bethesda | MD | $173.2M | 12 |
| MANAGEMENT SCIENCES FOR HEALTH INC | Arlington | VA | $168.8M | 27 |
| BROTHER'S BROTHER FOUNDATION | Pittsburgh | PA | $168.5M | 4 |
| AMERICAN FRIENDS OF HEBREW | New York | NY | $167.5M | 11 |
