| Memorial Hermann Health System | Houston | E210 Health Care | $7.6B | 30 |
| Michael & Susan Dell Foundation | Austin | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $4.3B | 1 |
| METHODIST HOSPITAL GROUP | Houston | — | $3.9B | 60 |
| Texas Children's Hospital | Bellaire | E240 Health Care | $3.8B | 28 |
| THE METHODIST HOSPITAL | Houston | E20 Health Care | $3.3B | 5 |
| BANK OF AMERICA GROUP BENEFITS PROGRAM TRUST | Dallas | Y43 Mutual & Membership Benefit | $2.8B | 1 |
| Texas Children's Health Plan | Bellaire | E310 Health Care | $2.8B | 26 |
| BOY SCOUTS OF AMERICA | Irving | O410 Youth Development | $2.7B | 17 |
| Baylor College of Medicine | Houston | B500 Education | $2.6B | 27 |
| CHILDREN'S HEALTH SYSTEM OF TEXAS | Dallas | E240 Health Care | $2.4B | 37 |
| Cook Children's Medical Center | Fort Worth | E240 Health Care | $2.2B | 28 |
| Methodist Hospitals of Dallas | Dallas | E200 Health Care | $2.1B | 18 |
| AT&T VEBA TRUST | Dallas | — | $2.1B | 1 |
| Baylor University Medical Center | Dallas | E220 Health Care | $1.7B | 13 |
| Scott & White Memorial Hospital | Dallas | E220 Health Care | $1.7B | 21 |
| Scott and White Health Plan | Dallas | — | $1.6B | 11 |
| BAYLOR UNIVERSITY | Waco | B430 Education | $1.5B | 62 |
| THE SAROFIM FOUNDATION | Houston | — | $1.4B | 1 |
| TEXAS MUTUAL INSURANCE COMPANY | Austin | — | $1.4B | 47 |
| Texas Health Resources | Arlington | E210 Health Care | $1.4B | 40 |
| Mother Frances Hospital Regional Health Care Center | Irving | E220 Health Care | $1.3B | 30 |
| TMH PHYSICIAN ORGANIZATION | Houston | — | $1.3B | 35 |
| Texas Health Harris Methodist Hospital | Fort Worth | E220 Health Care | $1.2B | 19 |
| Driscoll Children's Health Plan | Corpus Christi | E80 Health Care | $1.2B | 13 |
| Baylor Scott & White Health | Dallas | E21 Health Care | $1.2B | 22 |
| HealthTexas Provider Network | Dallas | E320 Health Care | $1.2B | 24 |
| TEXAS CHRISTIAN UNIVERSITY | Fort Worth | B430 Education | $1.2B | 23 |
| Scott & White Clinic | Dallas | E30 Health Care | $1.2B | 19 |
| PARKLAND COMMUNITY HEALTH PLAN INC | Dallas | — | $1.1B | 18 |
| Southern Methodist University | Dallas | B430 Education | $1.1B | 18 |
| CHI ST LUKE'S HEALTH BAYLOR COLLEGE OF | Houston | E220 Health Care | $1.1B | 11 |
| William Marsh Rice University | Houston | B430 Education | $1.1B | 39 |
| Driscoll Children's Hospital | Corpus Christi | E240 Health Care | $1.1B | 20 |
| Christus Santa Rosa Health Care Corporation | San Antonio | E200 Health Care | $1.1B | 32 |
| Christus Health | Irving | E210 Health Care | $1B | 41 |
| IDEA Public Schools | Weslaco | B20 Education | $1B | 28 |
| American Heart Association Inc | Dallas | G430 Diseases, Disorders & Medical Disciplines | $972.8M | 17 |
| Hendrick Medical Center | Abilene | E220 Health Care | $940.8M | 28 |
| Southwest Research Institute | San Antonio | U990 Science & Technology | $926.4M | 36 |
| CHRISTUS TRINITY CLINIC | Irving | E320 Health Care | $926.2M | 47 |
| SOUTHWEST KEY PROGRAMS INC | Austin | P840 Human Services | $921.5M | 29 |
| Christus Spohn Health System Corporation | Corpus Christi | E210 Health Care | $915.4M | 25 |
| Cook Children's Health Plan | Fort Worth | E31 Health Care | $892.6M | 18 |
| PEDERNALES ELECTRIC COOPERATIVE INC | Johnson City | — | $882.8M | 22 |
| Texas Health Presbyterian Hospital Dallas | Dallas | E22 Health Care | $788.7M | 23 |
| DENTON COUNTY ELECTRIC COOPERATIVE INC | Corinth | — | $780.8M | 22 |
| Texas Children's Physician Group | Bellaire | E30 Health Care | $780.3M | 22 |
| Shannon Medical Center | San Angelo | E220 Health Care | $740.3M | 27 |
| SOUTH TEXAS ELECTRIC COOPERATIVE INC | Nursery | — | $688.8M | 27 |
| LAURA AND JOHN ARNOLD FOUNDATION | Houston | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $687.3M | 0 |
