| Alpha Epsilon Pi Gamma Chi Chapter | Columbia | B83 Education | $364k | 0 |
| THE WORLD FAMOUS BLUE CRAB FESTIVAL INC | Little River | A20 Arts, Culture & Humanities | $364k | 0 |
| BIG BROTHERS BIG SISTERS OF THE UPSTATE | Greenville | O30 Youth Development | $363k | 1 |
| BLACK FOOD TRUCK FESTIVAL FOUNDATION | Charleston | A23 Arts, Culture & Humanities | $363k | 0 |
| THE PROPELLER CLUB OF THE UNITED | Charleston | — | $363k | 0 |
| UNITED MINISTRIES OF CLINTON | Clinton | P20 Human Services | $363k | 1 |
| PITTS COMMUNITY SENIOR INC | Greenville | L21 Housing & Shelter | $362k | 0 |
| LIFE OVER COFFEE | Greer | F60 Mental Health & Crisis Intervention | $362k | 2 |
| KAIROS | Charleston | X20 Religion-Related | $362k | 6 |
| SCOTTISH RITE ORIENT | Columbia | Y40Z Mutual & Membership Benefit | $361k | 0 |
| UPSTATE CAROLINA ADAPTIVE GOLF | Greenville | P99 Human Services | $361k | 1 |
| WHS WILDCAT ATHLETIC BOOSTER | Piedmont | B112 Education | $361k | 0 |
| THE FLOWERTOWN PLAYERS INC | Summerville | — | $361k | 0 |
| GREATER IRMO CHAMBER OF COMMERCE | Irmo | — | $360k | 0 |
| JACKSON FIRST ALERT | Jackson | E39Z Health Care | $360k | 4 |
| SHANE WILLARD MINISTRIES | Ladson | X20 Religion-Related | $360k | 1 |
| THE STRAY DOG SOCIETY | Mount Pleasant | B12 Education | $360k | 0 |
| CAREFIRST CAROLINA FOUNDATION | Hartsville | E70 Health Care | $360k | 1 |
| FLORENCE SYMPHONY ORCHESTRA | Florence | A69Z Arts, Culture & Humanities | $359k | 0 |
| LOWCOUNTRY FOUNDATION FOR WOUNDED MILITARY HEROS | Bluffton | A12 Arts, Culture & Humanities | $359k | 0 |
| HAPPY WHEELS INC | Lexington | G12 Diseases, Disorders & Medical Disciplines | $359k | 0 |
| Greenville Woodworkers Guild Inc | Greenville | B99 Education | $359k | 0 |
| MARSHVIEW COMMUNITY ORGANIC FARM | Saint Helena Island | O50 Youth Development | $358k | 0 |
| HOLY CITY ARTS & LYRIC OPERA | Mt Pleasant | A60 Arts, Culture & Humanities | $358k | 1 |
| LITTLE PEE DEE MANOR | Mullins | Z99Z Unknown | $357k | 0 |
| NEW FIELDS WORLD WIDE MINISTRIES | Chesnee | I80 Crime & Legal-Related | $357k | 0 |
| SOUTHEAST ASSOCIATION OF RAIL SHIPPERS | Fort Mill | S41 Community Improvement & Capacity Building | $357k | 0 |
| Stone Lake Community Club Inc | Greenville | N50 Recreation & Sports | $357k | 0 |
| WINNERS TRAVEL FOUNDATION INC | Mayesville | P40 Human Services | $357k | 0 |
| THE WOMEN'S SHELTER | Columbia | F22Z Mental Health & Crisis Intervention | $356k | 1 |
| THE MASTER'S MISSION INC | North Myrtle Beach | Q330 International, Foreign Affairs & National Security | $356k | 1 |
| ARTS COUNCIL OF ROCK HILL AND | Rock Hill | — | $356k | 0 |
| WLS FOUNDATION | Anderson | W99 Public & Societal Benefit | $356k | 2 |
| CLEMSON ANDERSON SOCCER ALLIANCE | Sandy Springs | N64 Recreation & Sports | $356k | 0 |
| Princetonians for Free Speech | Kiawah Island | R60 Civil Rights, Social Action & Advocacy | $356k | 0 |
| JUSTICE 360 | Columbia | R69Z Civil Rights, Social Action & Advocacy | $355k | 1 |
| OSIA Lodge 2662 | Myrtle Beach | — | $354k | 0 |
| SOUTH CAROLINA INFORMATION | Columbia | — | $354k | 0 |
| BEYOND OUR WALLS INC | North Charleston | B90 Education | $354k | 1 |
| BERKELEY COUNTY CHAMBER OF COMMERCE | Moncks Corner | — | $354k | 1 |
| SPARTANBURG ART MUSEUM | Spartanburg | — | $354k | 0 |
| JOINT LABOR MANAGEMENT COMMITTEE OF | Bluffton | — | $354k | 1 |
| SOUTH CAROLINA ASSISTED LIVING | Irmo | — | $353k | 1 |
| CHESNEE COMMUNITY VOLUNTEER FIRE DEPARTMENT | Chesnee | M24 Public Safety, Disaster Preparedness & Relief | $353k | 0 |
| RICHLAND COUNTY COURT APPOINTED SPECIAL | Columbia | — | $352k | 0 |
| HOLLYWILD ANIMAL PARK INC | Wellford | D500 Animal-Related | $352k | 1 |
| Aiken Junior Golf Foundation | Aiken | N6A Recreation & Sports | $352k | 1 |
| GOODWORKS INC | Chapin | L25 Housing & Shelter | $352k | 0 |
| WILBUR S SMITH AND MARGARET P SMITH | Hodges | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $351k | 0 |
| SOUTH CAROLINA NURSES ASSOCIATION | Columbia | — | $351k | 0 |
