| Florence Downtown Development Corporation Inc | Florence | C50 Environment | $422k | 0 |
| SOUTH CAROLINA ARTS ALLIANCE | Spartanburg | — | $421k | 1 |
| SWITCH | Greenville | P20 Human Services | $421k | 1 |
| PICKENS COUNTY HUMANE SOCIETY | Liberty | D200 Animal-Related | $421k | 1 |
| The St James Learning Center | Marion | B11 Education | $420k | 0 |
| EXCELSIOR ACADEMY | Irmo | B20 Education | $420k | 0 |
| THE ASSOCIATION OF SOUTHEASTERN BIOLOGISTS | Newberry | Z99 Unknown | $420k | 0 |
| SOUTH CAROLINA CITIZENS FOR LIFE INC | Columbia | — | $419k | 1 |
| REALTOR ASSOCIATION OF THE GREATER PEE DEE | Florence | — | $419k | 1 |
| LITTLE PEE DEE MANOR | Mullins | Z99Z Unknown | $418k | 0 |
| AHEPA 284 II INC | Columbia | L20 Housing & Shelter | $418k | 0 |
| Clover Elite Futbol Club | York | N64 Recreation & Sports | $418k | 0 |
| Upstate Youth Development Foundation dba First Tee - Upstate South Carolina | Greenville | N6A Recreation & Sports | $417k | 1 |
| Performing Arts and Science Academy Pasa | Marion | A20 Arts, Culture & Humanities | $416k | 4 |
| COLLETON COUNTY COUNCIL ON AGING | Walterboro | P81Z Human Services | $415k | 1 |
| KELLYS KITCHEN | St Helena Island | K99 Food, Agriculture & Nutrition | $415k | 0 |
| DILLON COUNTY COUNCIL ON AGING | Dillon | P81Z Human Services | $414k | 1 |
| CHAPIN ACADEMY | Chapin | B20 Education | $414k | 3 |
| TRIDENT URBAN LEAGUE | Charleston | P20 Human Services | $414k | 0 |
| GREENWOOD COMMUNITY THEATRE INC | Greenwood | A650 Arts, Culture & Humanities | $414k | 0 |
| AMERICAN LEGION POST 166 | Goose Creek | — | $413k | 0 |
| ALPHA SOCCER ACADEMY | Fort Mill | O50 Youth Development | $413k | 2 |
| ABC Crisis Pregnancy Center Inc | Florence | P40 Human Services | $413k | 1 |
| PI KAPPA PHI FRATERNITY SIGMA CHAPTER | Columbia | B83 Education | $412k | 0 |
| OLD TOWN ASSOCIATION | Rock Hill | S20 Community Improvement & Capacity Building | $412k | 0 |
| CAROLINAS COUNCIL OF HOUSING REDEVELOPMENT & CODES OFFICIALS | Marion | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $412k | 0 |
| PARTNERSHIP GRAND STRAND | Myrtle Beach | S11 Community Improvement & Capacity Building | $411k | 1 |
| Coventry Foundation Inc | Columbia | A80 Arts, Culture & Humanities | $411k | 0 |
| GEORGETOWN BULLDOG BOOSTER CLUB | Georgetown | — | $410k | 0 |
| Palmetto Community Health Care | Rock Hill | E300 Health Care | $410k | 1 |
| WESTMINSTER SENIOR OUTREACH | Westminster | P81 Human Services | $409k | 0 |
| SOUTH CAROLINA BOATING AND FISHING ALLIANCE | Chapin | — | $409k | 1 |
| HUMANE SOCIETY OF MARLBORO COUNTY INC | Bennettsville | D20 Animal-Related | $409k | 0 |
| DAVID MCDONALD MINISTRIES | Summerville | X20 Religion-Related | $409k | 2 |
| Southeastern Elite Competitors | Rock Hill | N12 Recreation & Sports | $408k | 0 |
| UMOJA VILLAGE | Aiken | P01 Human Services | $408k | 6 |
| CLEMSON AREA CHAMBER OF COMMERCE INC | Clemson | — | $408k | 1 |
| ASSOCIATION OF CANCER CENTER ADMINISTRATORS | Charleston | H30 Medical Research | $408k | 0 |
| JUSTICE 360 | Columbia | R69Z Civil Rights, Social Action & Advocacy | $407k | 1 |
| Rotary International District 7770 | Hilton Head Island | — | $407k | 0 |
| ANDERSON LIFE CRISIS PREGNANCY CENTER | Anderson | E400 Health Care | $406k | 1 |
| RESPITE CARE OF CHARLESTON | Charleston | P82 Human Services | $406k | 1 |
| JASPER COUNTY CHAMBER OF COMMERCE | Ridgeland | — | $406k | 2 |
| SOUTH CAROLINA DISTRICT DATA GOVERNANCE GROUP INC | Gilbert | B02 Education | $405k | 1 |
| TRAVELERS REST HISTORICAL SOCIETY | Travelers Rest | A80 Arts, Culture & Humanities | $405k | 0 |
| COMMUNICATIONS WORKERS OF AMERICA 3704 | Hanahan | — | $405k | 3 |
| HOME ALLIANCE INC | Myrtle Beach | L41 Housing & Shelter | $404k | 1 |
| SOUTH CAROLINA COMMUNITY CAPITAL ALLIANCE | Charleston | S30 Community Improvement & Capacity Building | $404k | 0 |
| DEPARTMENT OF SC VFW OF UNITED STATES | Lexington | W30 Public & Societal Benefit | $404k | 1 |
| Dog4U Inc | Camden | D20 Animal-Related | $404k | 0 |
