| ADVANCED TECHNOLOGY INTERNATIONAL | Summerville | U99 Science & Technology | $4.8B | 25 |
| Prisma Health-Upstate | Greenville | E22 Health Care | $3.2B | 24 |
| Prisma Health-Midlands | Greenville | E210 Health Care | $1.8B | 25 |
| LEXINGTON HEALTH INC | West Columbia | E20 Health Care | $1.6B | 11 |
| CENTRAL ELECTRIC POWER COOPERATIVE INC | Columbia | — | $1.5B | 52 |
| MCLEOD REGIONAL MEDICAL CENTER OF | Florence | E220 Health Care | $1.3B | 13 |
| Prisma Health-University Medical Group | Greenville | E31 Health Care | $893.4M | 25 |
| St Francis Hospital Inc | Greenville | — | $846.5M | 18 |
| Bon Secours-St Francis Xavier Hospital Inc | Charleston | E220 Health Care | $580.5M | 24 |
| THE BLACKBAUD GIVING FUND | Charleston Sc | T12 Philanthropy, Voluntarism & Grantmaking Foundations | $561.4M | 2 |
| Roper Hospital Inc | Charleston | E220 Health Care | $539.5M | 28 |
| Apella Health Management Inc | Spartanburg | T11 Philanthropy, Voluntarism & Grantmaking Foundations | $473.8M | 11 |
| BERKELEY ELECTRIC COOPERATIVE INC | Moncks Corner | — | $437.1M | 15 |
| MCLEOD LORIS SEACOAST HOSPITAL | Florence | E20 Health Care | $422.9M | 14 |
| Prisma Health Medical Group-Midlands | Greenville | B03 Education | $386.1M | 25 |
| CONWAY HOSPITAL INC | Conway | E220 Health Care | $358.2M | 14 |
| MCLEOD HEALTH | Florence | E210 Health Care | $340.8M | 12 |
| Joy Unspeakable Foundation | Charleston | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $300.4M | 0 |
| GEORGETOWN MEMORIAL HOSPITAL | Georgetown | E220 Health Care | $267.1M | 13 |
| MCLEOD PHYSICIAN ASSOCIATES II | Florence | E60 Health Care | $258M | 9 |
| THE CHARTER INSTITUTE AT ERSKINE INC | Columbia | B99 Education | $244.3M | 4 |
| MEDICAL TECHNOLOGY ENTERPRISE CONSORTIUM | Summerville | U05 Science & Technology | $234.5M | 3 |
| WACCAMAW COMMUNITY HOSPITAL | Georgetown | E200 Health Care | $225.6M | 13 |
| FURMAN UNIVERSITY | Greenville | B420 Education | $223.2M | 20 |
| Prisma Health Tuomey | Greenville | E22 Health Care | $215.3M | 21 |
| GEORGETOWN HOSPITAL SYSTEM | Georgetown | E210 Health Care | $209.5M | 10 |
| HORRY ELECTRIC COOPERATIVE INC | Conway | W80 Public & Societal Benefit | $203.5M | 17 |
| Greenville Health Corporation | Greenville | E60 Health Care | $196.3M | 22 |
| ROPER ST FRANCIS HEALTHCARE | Charleston | E210 Health Care | $191.2M | 27 |
| Roper St Francis Physicians Network | Charleston | E31 Health Care | $189.8M | 21 |
| HOPEHEALTH INC | Florence | E99 Health Care | $184.5M | 18 |
| PALMETTO ELECTRIC COOPERATIVE INC | Ridgeland | — | $182.9M | 20 |
| BLUE RIDGE ELECTRIC COOPERATIVE | Pickens | — | $178.7M | 15 |
| MID-CAROLINA ELECTRIC COOPERATIVE | Lexington | — | $157.8M | 16 |
| Bon Secours Medical Group Greenville Specialty Care LLC | Greenville | E30 Health Care | $155.6M | 18 |
| Roper St Francis Hospital - Berkeley Inc | Summerville | E20 Health Care | $152.1M | 27 |
| Anderson University | Anderson | B420 Education | $148.4M | 12 |
| AIKEN ELECTRIC COOPERATIVE INC | Aiken | — | $145.7M | 18 |
| The Blood Connection Inc | Piedmont | E610 Health Care | $144.4M | 14 |
| YORK ELECTRIC COOPERATIVE INC | York | — | $141.2M | 15 |
| WOFFORD COLLEGE | Spartanburg | — | $138.5M | 9 |
| SOUTHEASTERN FREIGHT LINES | Columbia | — | $137.3M | 0 |
| Prisma Health | Greenville | E21 Health Care | $136.6M | 36 |
| SANTEE ELECTRIC COOPERATIVE INC | Kingstree | — | $135.9M | 16 |
| IPTAY | Clemson | O50 Youth Development | $122.7M | 11 |
| Roper St Francis Mt Pleasant Hospital | Mount Pleasant | E220 Health Care | $121.9M | 26 |
| WELVISTA | Columbia | E70 Health Care | $120.8M | 7 |
| Charleston Southern University | Charleston | B430 Education | $116.1M | 16 |
| BJU Inc | Greenville | B24 Education | $114.9M | 8 |
| MCLEOD HEALTH CLARENDON | Florence | E22 Health Care | $91.6M | 12 |
