| SOUTH CAROLINA NURSES ASSOCIATION | Columbia | — | $351k | 0 |
| BENJAMIN HOUSE MINISTRIES | Moore | P20 Human Services | $351k | 0 |
| CAROLINAS CHAPTER OF SIOR LTD | Charleston | — | $351k | 0 |
| Theology Matters Inc | Greenwood | X83 Religion-Related | $350k | 3 |
| AL-AMIN TRUST FUND | Columbia | X40 Religion-Related | $350k | 0 |
| Beyond Our Gates Foundation of Kiawah & | Johns Island | T31 Philanthropy, Voluntarism & Grantmaking Foundations | $350k | 0 |
| Darlington African American Museum | Hartsville | A50 Arts, Culture & Humanities | $350k | 0 |
| AMOR HEALING KITCHEN INC | Charleston | K30 Food, Agriculture & Nutrition | $350k | 1 |
| CAROLINA HUMAN REINVESTMENT | Georgetown | I40 Crime & Legal-Related | $349k | 1 |
| FINE ARTS PREPARATORY SCHOOL | Moore | B29 Education | $349k | 0 |
| THE CAROLINAS CHAPTER OF THE AMERIC | Chapin | B60 Education | $349k | 0 |
| Makers Collective | Greenville | S20 Community Improvement & Capacity Building | $349k | 3 |
| THE SANDERS FAMILY FOUNDATION | Greenville | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $349k | 0 |
| International School of Greenville | Greenville | B24 Education | $349k | 1 |
| THE SCHOOL FOUNDATION INC | Florence | T30 Philanthropy, Voluntarism & Grantmaking Foundations | $349k | 1 |
| NATIONAL HIGH SCHOOL STRENGTH COACHES | Seneca | — | $349k | 0 |
| CHRISTIAN COALITION | Charleston | — | $349k | 1 |
| NEIGHBORHOOD FOCUS | Greenville | P20 Human Services | $348k | 1 |
| THE NEXT IT GIRL | Charleston | O53 Youth Development | $348k | 1 |
| HISTORIC PARADISE FOUNDATION NFP | Fort Mill | T50 Philanthropy, Voluntarism & Grantmaking Foundations | $348k | 3 |
| COMMUNITY KITCHEN INC OF MYRTLE BEACH | Myrtle Beach | K31Z Food, Agriculture & Nutrition | $347k | 0 |
| SIDEWALK HOPE INC | Spartanburg | O50 Youth Development | $347k | 0 |
| LOCAL 470 APPRENTICESHIP FUND | Graniteville | J22 Employment | $346k | 1 |
| BERKELEY HIGH SCHOOL ATHLETIC | Moncks Corner | B112 Education | $346k | 0 |
| University of South Carolina Theta Chi Fraternity | Columbia | — | $345k | 0 |
| HARVEST FREE MEDICAL CLINIC | North Charleston | E30 Health Care | $345k | 2 |
| CRW EVENTS | North Charleston | N60 Recreation & Sports | $345k | 1 |
| Sarah Simpson Gossett Home Inc | Greenville | L22 Housing & Shelter | $345k | 0 |
| DAVIDS TABLE INC | Greenville | O55 Youth Development | $345k | 2 |
| SOUTH CAROLINA HIGH SCHOOL RODEO ASSOCIATION | Anderson | N70 Recreation & Sports | $344k | 0 |
| Columbia Parks & Recreation Foundation | Columbia | N32 Recreation & Sports | $344k | 0 |
| SC Women's Leadership Network | Columbia | W70 Public & Societal Benefit | $344k | 0 |
| THE CHAPMAN FAMILY CHARITABLE TRUST | Columbia | — | $344k | 0 |
| ALLIANCE FOR FULL ACCEPTANCE | Charleston | R26 Civil Rights, Social Action & Advocacy | $343k | 2 |
| JOHN A WHITE FAMILY FOUNDATION INC | Hilton Head | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $343k | 0 |
| BEAUFORT WOMENS CENTER | Beaufort | — | $343k | 1 |
| SUZERAIN | Lexington | P80 Human Services | $342k | 1 |
| PLEASANT GROVE ACADEMY | Marion | B21 Education | $342k | 2 |
| HISTORIC BLUFFTON FOUNDATION | Bluffton | — | $341k | 0 |
| 721 MINISTRIES INC | Columbia | X03 Religion-Related | $340k | 1 |
| Brown Family Ministries Inc | Travelers Rest | X20 Religion-Related | $340k | 2 |
| BILL JENNIE & HARRY ACKERMAN FOUNDATION | Charleston | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $340k | 2 |
| SOUTH CAROLINA FIRST STEPS TO | Greenwood | — | $340k | 0 |
| WILBUR S SMITH AND SALLY J SMITH | Charleston | — | $340k | 0 |
| SOUTH CAROLINA FIRST STEPS | Greenwood | — | $340k | 0 |
| HILLENBRAND FAMILY FOUNDATION | Charleston | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $339k | 0 |
| The Laura E DuPont Foundation | Greenville | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $339k | 0 |
| TEACHERS SUPPLY CLOSET | Charleston | P58 Human Services | $339k | 1 |
| THE OUTSIDE FOUNDATION | Hilton Head Island | C60 Environment | $338k | 1 |
| GIRLS ON THE RUN TRI COUNTY SC | Rock Hill | O50 Youth Development | $338k | 1 |
