| PERSONAL ENRICHMENT THROUGH MENTAL HEALTH SERVICES INC | Pinellas Park | — | $22.2M | 6 |
| CONSOLIDATED CREDIT SOLUTIONS INC | Fort Lauderdale | — | $22.2M | 9 |
| LAKE TECHNICAL COLLEGE INC | Eustis | B29 Education | $22.1M | 3 |
| JUPITER CHRISTIAN SCHOOL INC | Jupiter | — | $22.1M | 3 |
| EPISCOPAL-CATHOLIC APARTMENTS INC | Winter Haven | — | $22.1M | 0 |
| BOYS & GIRLS CLUBS OF BROWARD COUNTY INC | Fort Lauderdale | O210 Youth Development | $22M | 5 |
| UNITED CEREBRAL PALSY ASSOCIATION OF MIAMI INC | Hialeah | G20 Diseases, Disorders & Medical Disciplines | $22M | 3 |
| THE CLUB AT MEDITERRA INC | Naples | N6A Recreation & Sports | $22M | 5 |
| DANIEL MEMORIAL INC | Jacksonville | F33Z Mental Health & Crisis Intervention | $21.9M | 6 |
| CORNERSTONE CHARTER ACADEMY INC | Miami | B29 Education | $21.8M | 1 |
| CENTRAL MANOR APARTMENTS | Ormond Beach | — | $21.8M | 0 |
| HEART OF FLORIDA UNITED WAY INC | Orlando | T70 Philanthropy, Voluntarism & Grantmaking Foundations | $21.8M | 7 |
| The Master's Academy of Central Florida Inc | Oviedo | X20 Religion-Related | $21.8M | 7 |
| THE FOUNDATION FOR OSCEOLA EDUCATION INC | Kissimmee | B29 Education | $21.8M | 1 |
| THE ICAHN MEDICAL RESEARCH FOUNDATION C/O ICAHN ASSOCIATES HOLDING LLC | Sunny Isles Beach | E05 Health Care | $21.7M | 1 |
| Michael-Ann Russell Jewish Community CENTER Inc | North Miami Beach | P200 Human Services | $21.7M | 7 |
| PINELLAS COMMUNITY FOUNDATION | Clearwater | T31Z Philanthropy, Voluntarism & Grantmaking Foundations | $21.7M | 1 |
| EARLY LEARNING COALITION OF ALACHUA COUNTY INC | Gainesville | B21 Education | $21.6M | 0 |
| MICKY AND MADELEINE ARISON FAMILY FOUNDATION C/O RICHARD KOHAN AFO LLC | Coral Gables | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $21.6M | 0 |
| Step Up Suncoast Inc | Sarasota | S30Z Community Improvement & Capacity Building | $21.6M | 7 |
| CHARLOTTE BEHAVIORAL HEALTH CARE INC | Punta Gorda | F32Z Mental Health & Crisis Intervention | $21.6M | 5 |
| MATER ACADEMY FOUNDATION INC | Miami | B11 Education | $21.6M | 0 |
| DIRECTIONS FOR MENTAL HEALTH INC | Clearwater | — | $21.5M | 6 |
| LE JARDIN COMMUNITY CENTER INC | Homestead | B210 Education | $21.4M | 2 |
| LIFE MANAGEMENT CENTER OF NORTHWEST FLORIDA INC | Panama City | F32Z Mental Health & Crisis Intervention | $21.4M | 7 |
| ARISON ARTS FOUNDATION C/O RICHARD KOHAN AFO LLC | Coral Gables | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $21.3M | 2 |
| CHAPMAN PARTNERSHIP INC | Miami | P850 Human Services | $21.3M | 9 |
| FAMILY CENTRAL INC | Wilton Manors | P330 Human Services | $21.3M | 5 |
| SAINT EDWARD'S SCHOOL INC | Vero Beach | B200 Education | $21.3M | 6 |
| FLORIDA UNITED METHODIST CHILDREN'S HOME INC | Deltona | P30 Human Services | $21.3M | 5 |
| Harvesters Credit Union | Cantonment | — | $21.2M | 15 |
| FAMILY FIRST INC | Tampa | P010 Human Services | $21.2M | 8 |
| AIDS SERVICE ASSOCIATION OF PINELLAS INC | Lakewood Ranch | — | $21.1M | 5 |
| GALASHIELS FUND LTD | Sarasota | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $21.1M | 0 |
| PANAMA CITY BEACH CONVENTION AND VISITORS BUREAU | Panama City Beach | S41 Community Improvement & Capacity Building | $21.1M | 1 |
| BELLEVIEW BILTMORE COUNTRY CLUB CORP | Belleair | — | $21M | 6 |
| SEASIDE SCHOOL CONSORTIUM INC | Jacksonville | B80 Education | $21M | 12 |
| DOCTORS' MEMORIAL HOSPITAL INC | Perry | E22 Health Care | $20.9M | 7 |
| THE COMMUNITY FOUNDATION - MARTIN / ST LUCIE INC | Stuart | P20 Human Services | $20.9M | 1 |
| EARLY LEARNING COALITION OF FLORIDAS HEARTLAND INC | Port Charlotte | B90 Education | $20.9M | 0 |
| NAVIGATOR ACADEMY OF LEADERSHIP INC | Brandon | — | $20.8M | 0 |
| THE ROCK FOUNDATION | North Palm Beach | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $20.8M | 0 |
| ROYAL PALM YACHT AND COUNTRY CLUB INC | Boca Raton | — | $20.8M | 7 |
| GUARDIANS CREDIT UNION | West Palm Beach | — | $20.8M | 8 |
| UNIVERSITY OF NORTH FLORIDA FOUNDATION INC | Jacksonville | B110 Education | $20.7M | 4 |
| FLORIDA GULF COAST UNIVERISTY FINANCING CORP | Fort Myers | T11 Philanthropy, Voluntarism & Grantmaking Foundations | $20.7M | 2 |
| BayCare Alliant Hospital Inc | Dunedin | E24 Health Care | $20.6M | 8 |
| YOUNG MENS CHRISTIAN ASSOCIATION OF GREATER ST PETERSBURG INC | St Petersburg | P270 Human Services | $20.6M | 6 |
| PLACE OF HOPE INC | Palm Beach Gardens | P70 Human Services | $20.6M | 5 |
| The Shelter for Abused Women & Children Inc | Naples | P43Z Human Services | $20.5M | 2 |
