| WARREN COUNTY ASSOCIATION FOR RETAR | Vicksburg | P82Z Human Services | $5M | 0 |
| MERCY HOUSE ADULT & TEEN CHALLENGE | Jackson | F22 Mental Health & Crisis Intervention | $4.9M | 2 |
| YOUNG MENS CHRISTIAN ASSOCIATION | Flowood | P27 Human Services | $4.9M | 3 |
| James W Hood Family Foundation | Jackson | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $4.8M | 0 |
| MISSISSIPPI CHILDREN'S MUSEUM | Jackson | A52 Arts, Culture & Humanities | $4.8M | 2 |
| SOUTH CENTRAL WATER ASSOCIATION INC | Raymond | — | $4.7M | 1 |
| UNITED METHODIST SENIOR SERVICES OF DESOTO COUNTY INC | Tupelo | E91 Health Care | $4.7M | 6 |
| WAYNE COUNTY SCHOOL FOUNDATION | Waynesboro | B242 Education | $4.7M | 0 |
| THE GERTRUDE C FORD FOUNDATION INC | Ridgeland | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $4.7M | 3 |
| ADAMS COUNTY WATER ASSOCIATION INC | Washington | — | $4.7M | 0 |
| MISSISSIPPI VOTES | Jackson | R40 Civil Rights, Social Action & Advocacy | $4.6M | 3 |
| SOUTHERN CHRISTIAN SERVICES FOR CHILDREN AND YOUTH INC | Jackson | P20 Human Services | $4.6M | 2 |
| STEWPOT COMMUNITY SERVICES INC | Jackson | — | $4.6M | 1 |
| CADENCE BANK FOUNDATION | Tupelo | T90 Philanthropy, Voluntarism & Grantmaking Foundations | $4.6M | 1 |
| GULF OF MEXICO ALLIANCE | Ocean Springs | C60 Environment | $4.5M | 3 |
| BILOXI COMMUNITY DEVELOPMENT CORP | Biloxi | L20 Housing & Shelter | $4.5M | 0 |
| TUPELO COUNTRY CLUB | Belden | — | $4.5M | 0 |
| MISSISSIPPI CONSORTIUM FOR INTERNATIONAL DEVELOPMENT INC | Jackson | Q300 International, Foreign Affairs & National Security | $4.4M | 2 |
| CENTRAL WATER ASSOCIATION INC | Philadelphia | — | $4.4M | 5 |
| MID-STATE OPPORTUNITY INC | Charleston | L81Z Housing & Shelter | $4.3M | 2 |
| CHICKASAW INKANA FOUNDATION | Tupelo | A80 Arts, Culture & Humanities | $4.3M | 0 |
| MARSHALL COUNTY WATER ASSOCIATION | Byhalia | — | $4.3M | 0 |
| ADAMS COUNTY CHRISTIAN SCHOOL | Natchez | B20 Education | $4.3M | 0 |
| National Association of Emergency Medical Technicians Inc | Ridgeland | — | $4.3M | 5 |
| GRACE HOUSE INC | Jackson | L99Z Housing & Shelter | $4.3M | 1 |
| AFRICAN BIBLE COLLEGES INC | Clinton | B58Z Education | $4.3M | 4 |
| UNITED METHODIST SENIOR SERVICES OF JACKSON AREA INC | Tupelo | P75Z Human Services | $4.3M | 6 |
| ANNANDALE INC | Madison | — | $4.2M | 0 |
| Central Mississippi Inc | Winona | P200 Human Services | $4.2M | 3 |
| HARBOR HOUSE OF JACKSON INC | Jackson | F34Z Mental Health & Crisis Intervention | $4.1M | 1 |
| MISSISSIPPI POWER FOUNDATION INC | Gulfport | T20Z Philanthropy, Voluntarism & Grantmaking Foundations | $4.1M | 0 |
| MISSISSIPPI GULF COAST YOUNG MEN'S CHRISTIAN ASSOCIATION INC | Ocean Springs | P27Z Human Services | $4.1M | 1 |
| North Mississippi Emergency Services | Tupelo | E20 Health Care | $4.1M | 3 |
| NATIONAL TILE CONTRACTORS ASSN INC | Jackson | — | $4.1M | 2 |
| COLUMBIA ACADEMY INC | Columbia | B20 Education | $4.1M | 0 |
| Claiborne County Family Health Center Inc | Port Gibson | E32Z Health Care | $4.1M | 9 |
| CATHOLIC SOCIAL AND COMMUNITY SERVICES | Biloxi | P200 Human Services | $4.1M | 1 |
| GULF COAST CENTER FOR NONVIOLENCE INC | Biloxi | — | $4.1M | 1 |
| MISSISSIPPI CENTER FOR JUSTICE | Jackson | I80 Crime & Legal-Related | $4.1M | 4 |
| MISSISSIPPI MANUFACTURERS ASSOCIATION | Jackson | — | $4.1M | 4 |
| INDIANOLA EDUCATIONAL FOUNDATION IN | Indianola | B24Z Education | $4.1M | 0 |
| THE STEVE AND MELODY GOLDING FOUNDATION | Vicksburg | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $4.1M | 0 |
| MAGNOLIA SPEECH SCHOOL | Madison | E56Z Health Care | $4M | 0 |
| HORN LAKE WATER ASSOCIATION INC | Horn Lake | — | $4M | 1 |
| AJFC COMMUNITY ACTION AGENCY | Natchez | P20Z Human Services | $4M | 0 |
| Outreach Health Services Inc | Shubuta | E320 Health Care | $4M | 5 |
| DELTA WILDLIFE INC | Stoneville | C300 Environment | $4M | 0 |
| FAYE AND CAREY POSEY EDUCATIONAL SCHOLARSHIP FOUNDATION | Hattiesburg | B82 Education | $3.9M | 0 |
| INTERNATIONAL OUTREACH MINISTRIES | Hattiesburg | X20 Religion-Related | $3.9M | 3 |
| North MS Rural Legal Services Inc | Oxford | I80Z Crime & Legal-Related | $3.9M | 4 |
