| FAMILY SERVICES INC | Charleston | — | $5.5M | 1 |
| NEWBERRY INVESTING IN CHILDREN'S EDUCATION | Newberry | B11 Education | $5.5M | 2 |
| CLEAR DOT CHARTER SCHOOL COLUMBIA INC | Columbia | B29 Education | $5.4M | 1 |
| LIBERTY STEAM CHARTER SCHOOL | Sumter | B20 Education | $5.4M | 1 |
| HOSPICE CARE OF THE LOWCOUNTRY INC | Bluffton | — | $5.4M | 3 |
| CLEMSON UNIVERSITY CONTINUING EDUCATION & CONFERENCE COMPLEX CORPORATION | Clemson | B110 Education | $5.4M | 6 |
| ROSA CLARK MEDICAL CLINIC ASSOCIATION INC | Seneca | — | $5.4M | 9 |
| BRIGHTER FUTURE EMPLOYMENT SERVICES | Columbia | J99 Employment | $5.4M | 2 |
| SOUTH CAROLINA FIRST STEPS TO SCHOOL READINESS-SPARTANBURG | Greenwood | B012 Education | $5.4M | 0 |
| POINSETT CLUB | Greenville | N50 Recreation & Sports | $5.4M | 1 |
| UPSTATE GREENWAYS AND TRAILS ALLIANCE | Greenville | C01 Environment | $5.4M | 0 |
| WINDWOOD FARM HOME FOR CHILDREN INC | Awendaw | F33Z Mental Health & Crisis Intervention | $5.3M | 1 |
| PEE DEE COALITION AGAINST DOMESTIC AND SEXUAL ASSAULT | Florence | — | $5.3M | 2 |
| SC MANUFACTURERS ALLIANCE GROUP INS TR | Columbia | Y43 Mutual & Membership Benefit | $5.3M | 0 |
| UNITED WAY OF THE PIEDMONT INC | Spartanburg | — | $5.3M | 2 |
| CAROLINA ART ASSOCIATION DBA GIBBES MUSEUM OF ART | Charleston | A24Z Arts, Culture & Humanities | $5.3M | 4 |
| COMMUNITY MEDICAL CLINIC OF KERSHAW | Camden | E700 Health Care | $5.3M | 0 |
| UNIVERSITY OF SOUTH CAROLINA ALUMNI ASSOCIATION | Columbia | B84Z Education | $5.3M | 4 |
| ODYSSEY ONLINE LEARNING | Chapin | B99 Education | $5.3M | 2 |
| WHITESVILLE RURAL FIRE DEPARTMENT DBA CENTRAL BERKELEY FIRE & EMS | Summerville | M24 Public Safety, Disaster Preparedness & Relief | $5.3M | 0 |
| MUSC STRATEGIC VENTURES | Charleston | E11 Health Care | $5.3M | 9 |
| The Lancaster County Partners for Youth | Lancaster | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $5.2M | 1 |
| Greenville Presbyterian Seminary Seminary | Taylors | B50 Education | $5.2M | 2 |
| SPECIAL OLYMPICS SOUTH CAROLINA | Lexington | — | $5.2M | 3 |
| Winthrop University Foundation | Rock Hill | B43I Education | $5.2M | 2 |
| Self Memorial Regional Health Services Inc | Greenwood | E21Z Health Care | $5.2M | 1 |
| SOUTH CAROLINA FOR ONLINE EDUCATION INC | Summerville | B29 Education | $5.2M | 0 |
| GIRL SCOUTS OF SOUTH CAROLINA - MOUNTAINS TO MIDLANDS INC | Greenville | O42 Youth Development | $5.2M | 3 |
| KIDS UPSTATE | Spartanburg | O23 Youth Development | $5.2M | 1 |
| MICHAEL J MUNGO FOUNDATION | Irmo | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $5.2M | 1 |
| BAMBERG COUNTY DISABILITIES AND SPECIAL NEEDS BOARD | Denmark | P80 Human Services | $5.1M | 1 |
| SOUTHEASTERN WILDLIFE EXPOSITION INC | Charleston | C99 Environment | $5.1M | 1 |
| CLIMB Fund | Charleston | S31 Community Improvement & Capacity Building | $5.1M | 1 |
| GREENVILLE TECH FOUNDATION INC | Greenville | B110 Education | $5.1M | 2 |
| TRINITY WELLNESS FOUNDATION | Marion | F20 Mental Health & Crisis Intervention | $5.1M | 0 |
| CHARLESTON SYMPHONY ORCHESTRA | Charleston | A690 Arts, Culture & Humanities | $5.1M | 1 |
| THE COLLEGE OF CHARLESTON ATHLETIC FUND | Charleston | N60J Recreation & Sports | $5.1M | 0 |
| DUTCH SHEETS MINISTRIES INC | Batesburgleesville | X21 Religion-Related | $5.1M | 2 |
| MUSC Foundation for Research Development | Charleston | H95Z Medical Research | $5.1M | 7 |
| HAVEN OF REST RESCUE MISSION | Anderson | L410 Housing & Shelter | $5.1M | 1 |
| THE SOUTHERN CONFERENCE | Spartanburg | — | $5.1M | 2 |
| THE FORRESTER CENTER FOR BEHAVIORAL HEALTH INC | Spartanburg | F99 Mental Health & Crisis Intervention | $5M | 1 |
| SCAGO PUBLIC FACILITIES CORPORATION FOR GEORGETOWN COUNTY | Georgetown | W99 Public & Societal Benefit | $5M | 0 |
| THE MARIA AND STEVEN MUNGO FOUNDATION | Charleston | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $5M | 0 |
| The Cooperative Ministry | Columbia | P600 Human Services | $5M | 4 |
| Lakelands Region Young Mens Christian Association | Laurens | P27Z Human Services | $5M | 1 |
| TRINITY COLLEGIATE SCHOOL | Darlington | B20Z Education | $5M | 1 |
| CENTER OF EXCELLENCE FOR EDUCATOR PREPARATION AND INNOVATION INC | Denmark | B99 Education | $5M | 0 |
| ARTS CENTER OF COASTAL CAROLINA | Hilton Head Island | A200 Arts, Culture & Humanities | $5M | 1 |
| ORANGEBURG PREPARATORY SCHOOLS INC ORANGEBURG PREPARATORY | Orangeburg | B20Z Education | $5M | 0 |
