| SOUTH CAROLINA STATE UNIVERSITY FOUNDATION INC | Orangeburg | — | $5M | 0 |
| CROSSOVER COMMUNICATIONS INTL | Columbia | X200 Religion-Related | $4.9M | 3 |
| CONWAY HOSPITAL EMERGENCY PROFESSIONAL SERVICES | Conway | E112 Health Care | $4.9M | 2 |
| YOUNG MENS CHRISTIAN ASSOCIATION OF ANDERSON SOUTH CAROLINA | Anderson | P270 Human Services | $4.9M | 1 |
| BMW Car Club of America Inc | Greer | N50 Recreation & Sports | $4.9M | 4 |
| CATAWBA AREA AGENCY ON AGING INC | Rock Hill | P80Z Human Services | $4.9M | 1 |
| The Graham Foundation | Greenville | — | $4.9M | 4 |
| WE TAKE IT FOR CHARITY INC | Bluffton | T50 Philanthropy, Voluntarism & Grantmaking Foundations | $4.9M | 0 |
| Winthrop University Real Estate Foundation Inc | Rock Hill | L20 Housing & Shelter | $4.9M | 0 |
| THE WILLIAMS BRICE EDWARDS CHARITABLE TRUST | Sumter | — | $4.9M | 0 |
| MAKE-A-WISH FOUNDATION OF SC INC | Greenville | E86Z Health Care | $4.8M | 1 |
| ONESPARTANBURG INC | Spartanburg | — | $4.8M | 3 |
| Look Up Lodge Christian Camp Inc Look Up Lodge Christian Camp | Travelers Rest | X20 Religion-Related | $4.8M | 1 |
| FRANCIS MARION UNIVERSITY EDUCATION FOUNDATION | Florence | B43I Education | $4.8M | 2 |
| HOPE CENTER FOR CHILDREN | Spartanburg | — | $4.8M | 1 |
| DORCHESTER SCHOOL DISTRICT TWO GROWTH RE | Summerville | B11 Education | $4.8M | 0 |
| CAROLINA ELITE SOCCER ACADEMY | Greenville | N60Z Recreation & Sports | $4.7M | 2 |
| TEAMSTERS LOCAL UNION NO 509 | West Columbia | — | $4.7M | 13 |
| CLEMSON ATHLETIC PROPERTIES COMPANY | Clemson | B12 Education | $4.7M | 4 |
| THE ANDY QUATTLEBAUM AND BLACKWELL FAMILY FOUNDATION | Pawleys Island | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $4.7M | 1 |
| TALL PINES STEM ACADEMY | Aiken | B29 Education | $4.7M | 0 |
| CHARLESTON METRO CHAMBER OF COMMERCE | North Charleston | — | $4.7M | 6 |
| GREENWOOD COUNTY COMMUNITY FOUNDATION INC | Greenwood | S20 Community Improvement & Capacity Building | $4.7M | 1 |
| THE BEAUFORT ACADEMY INC | Beaufort | B200 Education | $4.7M | 1 |
| YOUNG MEN'S CHRISTIAN ASSOC OF SUMTER | Sumter | P27Z Human Services | $4.6M | 1 |
| AMERICAN COLLEGE OF THE BUILDING ARTS | Charleston | B30 Education | $4.6M | 3 |
| PIEDMONT CLUB | Spartanburg | — | $4.6M | 2 |
| COMMUNITIES IN SCHOOLS OF SOUTH CAROLINA | North Charleston | B91Z Education | $4.6M | 4 |
| MEADOWS ROAD FOUNDATION (FKA COYDOG FOUNDATION) | Charleston | — | $4.6M | 0 |
| INTERNAT'L LONGSHOREMEN-ILA LOCAL 1422 | North Charleston | — | $4.6M | 17 |
| UPSTATE FOREVER | Greenville | C013 Environment | $4.6M | 3 |
| TURN90 | Charleston | I40 Crime & Legal-Related | $4.6M | 1 |
| THE LANDER FOUNDATION | Greenwood | — | $4.5M | 0 |
| CHARLESTON WINE & FOOD FESTIVAL | Charleston | K12 Food, Agriculture & Nutrition | $4.5M | 2 |
| SC STATE FIREFIGHTERS ASSOCIATION TR | Columbia | Y20 Mutual & Membership Benefit | $4.5M | 1 |
| SANTEE COOPER CREDIT UNION CU ANSWERS | Moncks Corner | — | $4.5M | 3 |
| Holly Tree Country Club Inc | Simpsonville | — | $4.5M | 1 |
| MILL VILLAGE MINISTRIES | Greenville | P20 Human Services | $4.5M | 1 |
| MODERN MINDS | Charleston | F32 Mental Health & Crisis Intervention | $4.5M | 1 |
| TOGETHER SC GROUP INSURANCE TRUST | Columbia | Y43 Mutual & Membership Benefit | $4.5M | 0 |
| HOPEFUL HORIZONS | Beaufort | X20 Religion-Related | $4.5M | 1 |
| Habitat for Humanity Horry County | Myrtle Beach | L20Z Housing & Shelter | $4.5M | 2 |
| CHARLESTON TRIDENT ASSOCIATION OF REALTORS INC | North Charleston | — | $4.5M | 1 |
| GREATER GREENVILLE CHAMBER OF COMMERCE | Greenville | — | $4.5M | 6 |
| THE CITADEL BRIGADIER FOUNDATION | Charleston | B42I Education | $4.5M | 2 |
| STC HEALTHCARE PARTNERS RISK RETENTION GROUP | Charleston | E11 Health Care | $4.5M | 0 |
| BUTLER ACADEMY | Hartsville | B29 Education | $4.5M | 1 |
| ALLEGRO CHARTER SCHOOL OF MUSIC | North Charleston | B20 Education | $4.5M | 2 |
| LOWCOUNTRY MONTESSORI SCHOOL | Beaufort | B24 Education | $4.5M | 1 |
| LANDMARKS FOR FAMILIES INC | North Charleston | P300 Human Services | $4.4M | 1 |
