| MEADOWS ROAD FOUNDATION (FKA COYDOG FOUNDATION) | Charleston | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $4.6M | 0 |
| MIDLANDS HOUSING ALLIANCE INC | Columbia | — | $4.6M | 1 |
| INTERNAT'L LONGSHOREMEN-ILA LOCAL 1422 | North Charleston | — | $4.6M | 17 |
| SOUTH CAROLINA INFANT MENTAL HEALTH ASSO | Charleston | F03 Mental Health & Crisis Intervention | $4.6M | 3 |
| CHARLESTON WINE & FOOD FESTIVAL | Charleston | K12 Food, Agriculture & Nutrition | $4.6M | 2 |
| TURN90 | Charleston | I40 Crime & Legal-Related | $4.6M | 1 |
| Catholic Charities of South Carolina | Charleston | — | $4.5M | 4 |
| BEAUFORT-JASPER YMCA OF THE LOWCOUNTRY INC | Port Royal | — | $4.5M | 1 |
| GROWING HOME SOUTHEAST INC | Cayce | P32 Human Services | $4.5M | 7 |
| SC STATE FIREFIGHTERS ASSOCIATION TR | Columbia | Y20 Mutual & Membership Benefit | $4.5M | 1 |
| Holly Tree Country Club Inc | Simpsonville | — | $4.5M | 1 |
| TOGETHER SC GROUP INSURANCE TRUST | Columbia | Y43 Mutual & Membership Benefit | $4.5M | 0 |
| HOPEFUL HORIZONS | Beaufort | X20 Religion-Related | $4.5M | 1 |
| DORCHESTER HABITAT FOR HUMANITY INC | Summerville | — | $4.5M | 1 |
| THE CITADEL BRIGADIER FOUNDATION | Charleston | B42I Education | $4.5M | 2 |
| ALLEGRO CHARTER SCHOOL OF MUSIC | North Charleston | B20 Education | $4.5M | 2 |
| Boys and Girls Clubs of York County | Rock Hill | O20Z Youth Development | $4.4M | 1 |
| LANDMARKS FOR FAMILIES INC | North Charleston | P300 Human Services | $4.4M | 1 |
| PALMETTO ACADEMY OF LEARNING AND SUCCESS | Myrtle Beach | B29 Education | $4.4M | 1 |
| Lakelands Region Young Mens Christian Association | Laurens | P27Z Human Services | $4.4M | 1 |
| Habitat for Humanity Horry County | Myrtle Beach | L20Z Housing & Shelter | $4.4M | 1 |
| Anderson County Detention Facilities Corporation | Anderson | I30 Crime & Legal-Related | $4.4M | 1 |
| FELTON LABORATORY CHARTER SCHOOL | Orangeburg | B25 Education | $4.4M | 0 |
| CROSSOVER COMMUNICATIONS INTL | Columbia | X200 Religion-Related | $4.4M | 3 |
| Jubilee Academy Inc | Columbia | P80 Human Services | $4.4M | 1 |
| JOSEPH H NEAL HEALTH COLLABORATIVE | Cayce | E24 Health Care | $4.4M | 1 |
| CLAYTON KING MINISTRIES | Anderson | X21 Religion-Related | $4.4M | 2 |
| JOHN K CROSSWELL HOME POF | Sumter | P70 Human Services | $4.4M | 5 |
| Health Sciences South Carolina | Columbia | E12 Health Care | $4.3M | 5 |
| SOUTH CAROLINA WHITMORE SCHOOL | Columbia | B29 Education | $4.3M | 1 |
| MARION COUNTY HEALTHCARE FOUNDATION | Mullins | E22 Health Care | $4.3M | 13 |
| SOUTH CAROLINA PREPARATORY ACADEMY | Anderson | B29 Education | $4.3M | 0 |
| CHARLESTON REGIONAL DEVELOPMENT ALLIANCE | Charleston | — | $4.3M | 5 |
| LEXINGTON MEDICAL CENTER FOUNDATION INC | West Columbia | — | $4.3M | 11 |
| The Kiawah Island Natural Habitat Conservancy Inc | Kiawah Island | C340 Environment | $4.3M | 1 |
| MUSC STRATEGIC VENTURES | Charleston | E11 Health Care | $4.3M | 5 |
| GBA Ships Florence Inc | Florence | X20 Religion-Related | $4.3M | 3 |
| THOMAS SUMTER ACADEMY INC | Rembert | B20Z Education | $4.3M | 0 |
| WINGS FOR KIDS | Charleston | P30 Human Services | $4.3M | 1 |
| COLLETON PREPARATORY ACADEMY INC | Walterboro | B24Z Education | $4.2M | 0 |
| Greenville Presbyterian Theological Seminary | Taylors | B50 Education | $4.2M | 6 |
| BOYS & GIRLS CLUBS OF THE LOWCOUNTRY INC | Bluffton | — | $4.2M | 2 |
| LANGSTON CHARTER MIDDLE SCHOOL INC | Greenville | B29 Education | $4.2M | 1 |
| UNIVERSITY INDUSTRY DEMONSTRATION PARTNERSHIP INC | Columbia | U01 Science & Technology | $4.2M | 1 |
| PATTISON'S ACADEMY | Charleston | B99 Education | $4.2M | 1 |
| THE ARC OF SOUTH CAROLINA | Lexington | — | $4.2M | 1 |
| CAROLINAS CREDIT UNION FOUNDATION | Columbia | B82Z Education | $4.2M | 1 |
| NEMOURS PLANTATION WILDLIFE FOUNDATION | Yemassee | D30 Animal-Related | $4.2M | 1 |
| SET FREE ALLIANCE (F/K/A WATER OF LIFE) | Greenville | Q33 International, Foreign Affairs & National Security | $4.2M | 2 |
| NUCOR EMPLOYEES CREDIT UNION | Florence | — | $4.2M | 1 |
