| GIRL SCOUTS OF SOUTH CAROLINA - MOUNTAINS TO MIDLANDS INC | Greenville | O42 Youth Development | $5.2M | 3 |
| MICHAEL J MUNGO FOUNDATION | Irmo | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $5.2M | 1 |
| Look Up Lodge Christian Camp Inc | Travelers Rest | X20 Religion-Related | $5.2M | 2 |
| BAMBERG COUNTY DISABILITIES AND SPECIAL NEEDS BOARD | Denmark | P80 Human Services | $5.1M | 1 |
| SOUTHEASTERN WILDLIFE EXPOSITION INC | Charleston | C99 Environment | $5.1M | 1 |
| GREENVILLE TECH FOUNDATION INC | Greenville | B110 Education | $5.1M | 2 |
| TRINITY WELLNESS FOUNDATION | Marion | F20 Mental Health & Crisis Intervention | $5.1M | 0 |
| GREENWOOD CHARTER ACADEMY | Greenwood | B20 Education | $5.1M | 1 |
| CHARLESTON SYMPHONY ORCHESTRA | Charleston | A690 Arts, Culture & Humanities | $5.1M | 1 |
| COMMUNITIES IN SCHOOLS OF SOUTH CAROLINA | North Charleston | B91Z Education | $5.1M | 3 |
| THE COLLEGE OF CHARLESTON ATHLETIC FUND | Charleston | N60J Recreation & Sports | $5.1M | 0 |
| DUTCH SHEETS MINISTRIES INC | Batesburgleesville | X21 Religion-Related | $5.1M | 2 |
| HAVEN OF REST RESCUE MISSION | Anderson | L410 Housing & Shelter | $5.1M | 1 |
| NUTRAMAX FAMILY FOUNDATION | Lancaster | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $5.1M | 0 |
| THE FORRESTER CENTER FOR BEHAVIORAL HEALTH INC | Spartanburg | F99 Mental Health & Crisis Intervention | $5M | 1 |
| SCAGO PUBLIC FACILITIES CORPORATION FOR GEORGETOWN COUNTY | Georgetown | W99 Public & Societal Benefit | $5M | 0 |
| The Cooperative Ministry | Columbia | P600 Human Services | $5M | 4 |
| TRINITY COLLEGIATE SCHOOL | Darlington | B20Z Education | $5M | 1 |
| PALMETTO AIDS LIFE SUPPORT SERVICES INC | Columbia | — | $5M | 3 |
| Alligator Rural Water Co Inc | McBee | X22 Religion-Related | $5M | 6 |
| CENTER OF EXCELLENCE FOR EDUCATOR PREPARATION AND INNOVATION INC | Denmark | B99 Education | $5M | 0 |
| ARTS CENTER OF COASTAL CAROLINA | Hilton Head Island | A200 Arts, Culture & Humanities | $5M | 1 |
| ORANGEBURG PREPARATORY SCHOOLS INC | Orangeburg | B20Z Education | $5M | 0 |
| CONWAY HOSPITAL EMERGENCY PROFESSIONAL SERVICES | Conway | E112 Health Care | $4.9M | 2 |
| YOUNG MENS CHRISTIAN ASSOCIATION OF ANDERSON SOUTH CAROLINA | Anderson | P270 Human Services | $4.9M | 1 |
| SOUTH CAROLINA QUANTUM ASSOCIATION | Columbia | B90 Education | $4.9M | 6 |
| ECONOMIC DEVELOPMENT PARTNERSHIP | Aiken | — | $4.9M | 1 |
| BMW Car Club of America Inc | Greer | N50 Recreation & Sports | $4.9M | 4 |
| The Graham Foundation | Greenville | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $4.9M | 4 |
| Winthrop University Real Estate Foundation Inc | Rock Hill | L20 Housing & Shelter | $4.9M | 0 |
| SOUTH CAROLINA COASTAL CONSERVATION LEAGUE INC | Charleston | C320 Environment | $4.9M | 5 |
| THE WILLIAMS BRICE EDWARDS CHARITABLE TRUST | Sumter | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $4.9M | 0 |
| MAKE-A-WISH FOUNDATION OF SC INC | Greenville | E86Z Health Care | $4.8M | 1 |
| ONESPARTANBURG INC | Spartanburg | — | $4.8M | 3 |
| CAROLINA ELITE SOCCER ACADEMY | Greenville | N60Z Recreation & Sports | $4.8M | 2 |
| FRANCIS MARION UNIVERSITY EDUCATION FOUNDATION | Florence | B43I Education | $4.8M | 2 |
| DORCHESTER SCHOOL DISTRICT TWO GROWTH RE | Summerville | B11 Education | $4.8M | 0 |
| TEAMSTERS LOCAL UNION NO 509 | West Columbia | — | $4.7M | 13 |
| LOWCOUNTRY MONTESSORI SCHOOL | Beaufort | B24 Education | $4.7M | 1 |
| NEW CAPERNAUM LIFE SERVICES | Columbia | S31 Community Improvement & Capacity Building | $4.7M | 0 |
| THE ANDY QUATTLEBAUM AND BLACKWELL FAMILY FOUNDATION | Pawleys Island | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $4.7M | 1 |
| CHARLESTON TRIDENT ASSOCIATION OF REALTORS INC | North Charleston | — | $4.7M | 1 |
| CHRISTIAN ACADEMY | Myrtle Beach | B24Z Education | $4.7M | 0 |
| TALL PINES STEM ACADEMY | Aiken | B29 Education | $4.7M | 0 |
| STC HEALTHCARE PARTNERS RISK RETENTION GROUP | Charleston | E11 Health Care | $4.7M | 0 |
| GREENWOOD COUNTY COMMUNITY FOUNDATION INC | Greenwood | S20 Community Improvement & Capacity Building | $4.7M | 1 |
| YOUNG MEN'S CHRISTIAN ASSOC OF SUMTER | Sumter | P27Z Human Services | $4.6M | 1 |
| AMERICAN COLLEGE OF THE BUILDING ARTS | Charleston | B30 Education | $4.6M | 3 |
| PIEDMONT CLUB | Spartanburg | — | $4.6M | 2 |
| HOUSE OF HOPE OF THE PEE DEE INC | Florence | P28Z Human Services | $4.6M | 2 |
