| Alligator Rural Water Co Inc | McBee | X22 Religion-Related | $4.4M | 7 |
| Anderson County Detention Facilities Corporation | Anderson | I30 Crime & Legal-Related | $4.4M | 1 |
| FELTON LABORATORY CHARTER SCHOOL | Orangeburg | B25 Education | $4.4M | 0 |
| THORNWELL CHARTER SCHOOL | Clinton | B29 Education | $4.4M | 0 |
| JOSEPH H NEAL HEALTH COLLABORATIVE | Cayce | E24 Health Care | $4.4M | 1 |
| CAROLINAS CREDIT UNION FOUNDATION | Columbia | B82Z Education | $4.4M | 1 |
| JOHN K CROSSWELL HOME POF | Sumter | P70 Human Services | $4.4M | 5 |
| ENGAGING CREATIVE MINDS | Charleston | B90 Education | $4.3M | 1 |
| SOUTH CAROLINA WHITMORE SCHOOL | Columbia | B29 Education | $4.3M | 1 |
| CHRISTIAN ACADEMY | Myrtle Beach | B24Z Education | $4.3M | 0 |
| EAST COOPER COMMUNITY OUTREACH | Mount Pleasant | P600 Human Services | $4.3M | 1 |
| MARION COUNTY HEALTHCARE FOUNDATION | Mullins | E22 Health Care | $4.3M | 13 |
| SOUTH CAROLINA PREPARATORY ACADEMY | Anderson | B29 Education | $4.3M | 0 |
| LEXINGTON MEDICAL CENTER FOUNDATION INC | West Columbia | — | $4.3M | 11 |
| The Kiawah Island Natural Habitat | Kiawah Island | C340 Environment | $4.3M | 1 |
| GBA Ships Florence Inc | Florence | X20 Religion-Related | $4.3M | 3 |
| THOMAS SUMTER ACADEMY INC | Rembert | B20Z Education | $4.3M | 0 |
| WINGS FOR KIDS | Charleston | P30 Human Services | $4.3M | 1 |
| MIDLANDS HOUSING ALLIANCE INC | Columbia | — | $4.2M | 1 |
| BOYS & GIRLS CLUBS OF THE | Bluffton | — | $4.2M | 2 |
| LANGSTON CHARTER MIDDLE SCHOOL INC | Greenville | B29 Education | $4.2M | 1 |
| THE ARC OF SOUTH CAROLINA | Lexington | — | $4.2M | 1 |
| NORTH MYRTLE BEACH CHAMBER OF | North Myrtle Beach | S41 Community Improvement & Capacity Building | $4.2M | 1 |
| PALMETTO ECONOMIC DEVELOPMENT CORP | Columbia | — | $4.1M | 21 |
| UNITED WAY OF KERSHAW COUNTY | Camden | — | $4.1M | 1 |
| BLUE LETTER BIBLE | Greenville | — | $4.1M | 7 |
| DORCHESTER HABITAT FOR HUMANITY INC | Summerville | — | $4.1M | 1 |
| Naturaland Trust | Greenville | C340 Environment | $4.1M | 2 |
| PATTISON'S ACADEMY | Charleston | B99 Education | $4.1M | 1 |
| HILTON HEAD ISLAND RECREATION | Hilton Head Island | — | $4.1M | 1 |
| SOUTH CAROLINA ASSOCIATION FOR | Charleston | S31 Community Improvement & Capacity Building | $4.1M | 2 |
| SANDHILLS SCHOOL | Columbia | — | $4.1M | 1 |
| BCD Rural Transportation | Moncks Corner | — | $4.1M | 0 |
| CHARLESTON REGIONAL DEVELOPMENT | Charleston | — | $4.1M | 7 |
| Movement Resources | Fort Mill | L99 Housing & Shelter | $4.1M | 0 |
| WO AND ANN POWERS FOUNDATION INC | Florence | T90Z Philanthropy, Voluntarism & Grantmaking Foundations | $4M | 12 |
| COLUMBIA UNITED FC DBA SOUTH CAROLINA | Columbia | — | $4M | 1 |
| SOUTH CAROLINA STATE FIREFIGHTERS' | Columbia | — | $4M | 1 |
| UPSTATE WARRIOR SOLUTION INC | Greenville | P60 Human Services | $4M | 1 |
| SISTERCARE INC | Columbia | — | $4M | 2 |
| Roper St Francis Ancillary Services | Ladson | E60 Health Care | $4M | 6 |
| NATIONAL WILD TURKEY FEDERATION ENDOWMENT FOUNDATION INC | Edgefield | — | $4M | 0 |
| LAKE CITY CREATIVE ALLIANCE | Lake City | A20 Arts, Culture & Humanities | $4M | 1 |
| THE HUMANITIES FOUNDATION INC | Charleston | L80Z Housing & Shelter | $4M | 2 |
| ABNEY FOUNDATION | Anderson | — | $3.9M | 6 |
| BLUFFTON SELF HELP INC | Bluffton | — | $3.9M | 2 |
| METROPOLITAN ARTS COUNCIL | Greenville | — | $3.9M | 1 |
| PALMETTO ACHIEVEMENT CENTER FOR | Columbia | B29 Education | $3.9M | 0 |
| HORRY COUNTY COUNCIL ON AGING INC | Conway | — | $3.9M | 2 |
| HARVESTERS MINISTRIES | Fort Mill | X20 Religion-Related | $3.9M | 2 |
