| TRAIL LIFE USA INC | Belton | O55 Youth Development | $6.1M | 4 |
| UPPER SAVANNAH CARE SERVICES | Greenwood | E70 Health Care | $6.1M | 1 |
| FIRST PRESBYTERIAN ACADEMY INC | Greenville | B24 Education | $6.1M | 0 |
| SOUTHEASTERN HOUSING AND COMMUNITY DEVELOPMENT | Barnwell | L80 Housing & Shelter | $6.1M | 0 |
| PICKENS CO COMM ON ALCOHOL & DRUG ABUSE | Pickens | — | $6.1M | 1 |
| LEXINGTON ONE SCHOOL FACILITIES CORPORATION | Lexington | B11 Education | $6.1M | 0 |
| PALMETTO UTILITY PROTECTION SERVICE INC | Columbia | — | $6M | 1 |
| FOOTHILLS AREA YMCA | Seneca | P27Z Human Services | $6M | 1 |
| EXCHANGE CLUB FAIR OF CHARLESTON INC | Ladson | — | $6M | 0 |
| BUCKSPORT WATER SYSTEM INC | Conway | K200 Food, Agriculture & Nutrition | $6M | 1 |
| COMPANION FOUNDATION | Charleston | L20 Housing & Shelter | $5.9M | 2 |
| RONALD MCDONALD HOUSE CHARITIES OF CHARLESTON SOUTH CAROLINA INC | Charleston | E86Z Health Care | $5.9M | 2 |
| CATAWBA AREA AGENCY ON AGING INC | Rock Hill | P80Z Human Services | $5.9M | 1 |
| South Carolina Research Foundation | Columbia | — | $5.9M | 6 |
| PEE DEE COALITION AGAINST DOMESTIC AND SEXUAL ASSAULT | Florence | — | $5.8M | 2 |
| WILD DUNES COMMUNITY ASSOCIATION INC | Isle Of Palms | L50 Housing & Shelter | $5.8M | 3 |
| PINEWOOD TRUSTEE INC C/O KERR LAW GROUP LLC | Mount Pleasant | — | $5.8M | 0 |
| SOUTH CAROLINA TRUCKING ASSOCIATION INC GROUP INSURANCE TRUST | Columbia | Y34 Mutual & Membership Benefit | $5.7M | 0 |
| NEW FOUNDATIONS HOME FOR CHILDREN | Anderson | P730 Human Services | $5.7M | 0 |
| LEAD ACADEMY | Greenville | B25 Education | $5.7M | 0 |
| MUSC Foundation for Research Development | Charleston | H95Z Medical Research | $5.6M | 6 |
| THE UNUMB CENTER FOR NEURODEVELOPMENT | Columbia | B28 Education | $5.6M | 0 |
| South Carolina Association of Realtors | Columbia | — | $5.6M | 6 |
| HOLY TRINITY CLASSICAL CHRISTIAN SCHOOL INC | Beaufort | B99 Education | $5.6M | 1 |
| THORNWELL CHARTER SCHOOL | Clinton | B29 Education | $5.6M | 0 |
| WACCAMAW COMMUNITY FOUNDATION | Murrells Inlet | S11 Community Improvement & Capacity Building | $5.6M | 1 |
| SUMMERVILLE FAMILY YOUNG MEN'S CHRISTIAN ASSOCIATION | Summerville | — | $5.6M | 2 |
| COLUMBIA MUSEUM OF ART | Columbia | A510 Arts, Culture & Humanities | $5.6M | 3 |
| SAFE HARBOR INC | Greenville | P43 Human Services | $5.6M | 3 |
| HISTORIC CHARLESTON FOUNDATION | Charleston | — | $5.5M | 3 |
| TRIDENT UNITED WAY | North Charleston | T70 Philanthropy, Voluntarism & Grantmaking Foundations | $5.5M | 5 |
| CAMPERDOWN ACADEMY INC | Greenville | B28Z Education | $5.5M | 1 |
| FAMILY SERVICES INC | Charleston | — | $5.5M | 1 |
| NEWBERRY INVESTING IN CHILDREN'S EDUCATION | Newberry | B11 Education | $5.5M | 2 |
| SANTEE COOPER CREDIT UNION | Moncks Corner | — | $5.5M | 2 |
| THE BEAUFORT ACADEMY INC | Beaufort | B200 Education | $5.4M | 1 |
| BUTLER ACADEMY | Hartsville | B29 Education | $5.4M | 1 |
| ROSA CLARK MEDICAL CLINIC ASSOCIATION INC | Seneca | — | $5.4M | 9 |
| POINSETT CLUB | Greenville | N50 Recreation & Sports | $5.4M | 1 |
| OAKBROOK PREPARATORY SCHOOL | Spartanburg | — | $5.3M | 1 |
| East Cooper Community Outreach | Mount Pleasant | P600 Human Services | $5.3M | 1 |
| THE SOUTHERN CONFERENCE | Spartanburg | — | $5.3M | 1 |
| SC MANUFACTURERS ALLIANCE GROUP INS TR | Columbia | Y43 Mutual & Membership Benefit | $5.3M | 0 |
| UNITED WAY OF THE PIEDMONT INC | Spartanburg | — | $5.3M | 2 |
| CAROLINA ART ASSOCIATION DBA GIBBES MUSEUM OF ART | Charleston | A24Z Arts, Culture & Humanities | $5.3M | 4 |
| COMMUNITY MEDICAL CLINIC OF KERSHAW | Camden | E700 Health Care | $5.3M | 0 |
| ODYSSEY ONLINE LEARNING | Chapin | B99 Education | $5.3M | 2 |
| PALMETTO SCHOLARS ACADEMY | North Charleston | B20 Education | $5.3M | 2 |
| SPECIAL OLYMPICS SOUTH CAROLINA | Lexington | — | $5.2M | 3 |
| Self Memorial Regional Health Services Inc | Greenwood | E21Z Health Care | $5.2M | 1 |
