| Acorn Global Advance | Taylors | T30 Philanthropy, Voluntarism & Grantmaking Foundations | $537k | 1 |
| CHARLESTON COUNTY MEDICAL SOCIETY | Charleston | — | $537k | 2 |
| KAPPA DELTA SORORITY - BETA ZETA UNIVERSITY OF SOUTH CAROLINA | Columbia | — | $537k | 0 |
| SOUTH CAROLINA WILDLIFE FEDERATION | Columbia | D013 Animal-Related | $537k | 1 |
| IMPACT SPORTS INTERNATIONAL | Spartanburg | X99 Religion-Related | $536k | 1 |
| OFFENSE DEFENSE EDUCATIONAL | Myrtle Beach | N116 Recreation & Sports | $535k | 0 |
| CAROLINA HUMAN REINVESTMENT | Georgetown | I40 Crime & Legal-Related | $535k | 0 |
| GREENVILLE SYMPHONY ENDOWMENT FUND INC | Greenville | A118 Arts, Culture & Humanities | $535k | 0 |
| BETSY M CAMPBELL FOUNDATION | Greenville | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $535k | 1 |
| SOUTH CAROLINA HEALTH INSURANCE POOL | Columbia | — | $535k | 0 |
| Therapy Resource Group | Fort Mill | B01 Education | $532k | 0 |
| DILLON HISTORIC SCHOOL FOUNDATION | Dillon | O99 Youth Development | $531k | 0 |
| THE BAILEY FOUNDATION C/O TNB FINANCIAL SERVICES | Clinton | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $531k | 1 |
| 3GEN MINISTRIES | Greer | X20 Religion-Related | $530k | 3 |
| MUMTAZ FOUNDATION | Columbia | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $530k | 0 |
| Second Chance Emergency Placement Inc | Spartanburg | — | $528k | 1 |
| HIGHWOOD APARTMENTS INC | Greenville | L20Z Housing & Shelter | $528k | 0 |
| WOUNDED NATUREORG | Mount Pleasant | C50 Environment | $528k | 1 |
| LEAN ENSEMBLE THEATER | Hilton Head Island | — | $527k | 1 |
| MOUNT PLEASANT SWIM CLUB PARENTS ASSOCIATION | Mount Pleasant | N116 Recreation & Sports | $526k | 0 |
| GREENVILLE CENTER FOR CREATIVE ARTS | Greenville | A25 Arts, Culture & Humanities | $526k | 1 |
| SAMMYS MISSION | Simpsonville | F20 Mental Health & Crisis Intervention | $525k | 0 |
| AMERICAN CIVIL LIBERTIES UNION OF SOUTH CAROLINA INC | Columbia | — | $524k | 2 |
| BIBLE WAY CHURCH OF GEORGETOWN | Georgetown | P330 Human Services | $524k | 3 |
| THE ANIMAL MISSION | Columbia | D200 Animal-Related | $522k | 1 |
| HOPEFUL RESTORATION GROUP INC | Little River | P99 Human Services | $522k | 0 |
| Spartanburg Youth Soccer Club Inc | Spartanburg | N64 Recreation & Sports | $522k | 0 |
| SHIELD MINISTRIES | North Charleston | P20 Human Services | $522k | 2 |
| SERVICE DOGS FOR VETERANS | Greenville | W30 Public & Societal Benefit | $521k | 2 |
| South Carolina Beverage Association Inc | Columbia | — | $521k | 1 |
| SOUTH CAROLINA RECREATION & PARKS ASSOCIATION INC | Lexington | N30C Recreation & Sports | $520k | 1 |
| THE SHARK CLUB INC | Murrells Inlet | B94 Education | $519k | 0 |
| THE FROM HIM AND THROUGH HIM FOUNDATION | Lexington | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $519k | 0 |
| CHRISTMASVILLE | Rock Hill | A27 Arts, Culture & Humanities | $519k | 0 |
| BABCOCK CENTER FOUNDATIONINC | West Columbia | P82I Human Services | $518k | 1 |
| SC Crime Stoppers Council | Walhalla | I20 Crime & Legal-Related | $518k | 0 |
| ASHLEY RIDGE ATHLETICS BOOSTER CLUB | Summerville | N60 Recreation & Sports | $518k | 0 |
| AHEPA 284 INC | Columbia | L20Z Housing & Shelter | $518k | 0 |
| ROPER MOUNTAIN SCIENCE CENTER ASSOCIATION | Greenville | — | $518k | 0 |
| A Moment of Hope | Columbia | X99 Religion-Related | $517k | 2 |
| PALMETTO ASSOCIATION FOR CHILDREN AND FAMILIES | Columbia | — | $517k | 1 |
| NURTURING CENTER INC | Columbia | P620 Human Services | $517k | 1 |
| AMERICAN LEGION NORTH STRAND POST 186 | Little River | — | $516k | 0 |
| JOHNSONVILLE RESCUE SQUAD AND AMBULANCE | Johnsonville | E62Z Health Care | $516k | 3 |
| JERRY AND ANITA ZUCKER FAMILY FOUNDATION INC | N Charleston | T20Z Philanthropy, Voluntarism & Grantmaking Foundations | $515k | 0 |
| UPSTATE MEDIATION CENTER | Greenville | I51 Crime & Legal-Related | $515k | 1 |
| LIGHTKEEPERS MARINA INC | Little River | N50 Recreation & Sports | $514k | 0 |
| SUMMERVILLE DREAM INC | Summerville | A80 Arts, Culture & Humanities | $513k | 1 |
| CHEROKEE HISTORICAL & PRESERVATION SOCIETY INC | Gaffney | B99 Education | $513k | 1 |
| THE PRIESTER FOUNDATION C/O SUSAN PRIESTER | Greenville | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $512k | 0 |
