| SOUTHERN ASSOCIATION OF STUDENT FINANCIAL AID ADMINISTRATORS | North Myrtle Beach | S41Z Community Improvement & Capacity Building | $512k | 0 |
| UU WORLD OF CHILDREN | Greenville | B110 Education | $512k | 1 |
| Florence & Gordon Holland Family Foundation | Hilton Head Island | T90 Philanthropy, Voluntarism & Grantmaking Foundations | $511k | 0 |
| MENTAL HEALTH AMERICA OF BEAUFORT-JASPER | Bluffton | F80 Mental Health & Crisis Intervention | $511k | 0 |
| CELEBRATE FREEDOM FOUNDATION | West Columbia | A840 Arts, Culture & Humanities | $511k | 0 |
| THE MUSEUM ASSOCIATION INC | Greenville | A12 Arts, Culture & Humanities | $510k | 0 |
| REDUX CONTEMPORARY ART CENTER | Charleston | A40 Arts, Culture & Humanities | $509k | 0 |
| THE FAMILY RESOURCE CENTER | Camden | — | $508k | 0 |
| JEHOVAH MISSIONARY BAPTIST CHURCH CHRISTIAN & ACADEMIC SCHOOL | Sumter | P33Z Human Services | $507k | 0 |
| MEALS ON WHEELS BLUFFTON/HILTON HEAD | Hilton Head | — | $506k | 0 |
| Pendleton Historic Foundation | Pendleton | — | $506k | 1 |
| Seth M Milliken Foundation Inc | Spartanburg | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $506k | 0 |
| TRINITY METHODIST CHURCH APARTMENT INC | Camden | L20Z Housing & Shelter | $505k | 0 |
| WILDLIFE ACTION INC | Mullins | D013 Animal-Related | $505k | 1 |
| AMERICAN LEGION SUMTER POST 15 | Sumter | — | $505k | 0 |
| J L MANN ATHLETIC BOOSTER CLUB INC | Greenville | B112 Education | $504k | 0 |
| DAVIDS TABLE INC | Greenville | O55 Youth Development | $504k | 3 |
| DORCHESTER COUNTY FIRST STEPS TO SCHOOL READINESS PARTNERSHIP | Greenwood | — | $504k | 1 |
| ROCK INTERNATIONAL | Greenville | X21 Religion-Related | $504k | 0 |
| HILTON HEAD AREA HOSPITALITY ASSOCIATION | Hilton Head Island | — | $504k | 1 |
| FOR INSPIRATION RECOGNITION OF SCIENCE AND TECHNOLOGY SOUTH CAROLINA | Ridgeville | O50 Youth Development | $502k | 0 |
| WILLIAMSBURG COUNTY FIRST STEPS TO SCHOOL READINESS PARTNERSHIP | Greenwood | — | $501k | 0 |
| ASHUTOSH THE LOVE OF SHIVA INC | Elgin | E30 Health Care | $500k | 0 |
| A Place For Us Ministries Inc | Greenwood | P42 Human Services | $500k | 0 |
| LET THERE BE MOM INC | Greenville | P40 Human Services | $500k | 1 |
| MAGNOLIA CEMETERY TRUST | Charleston | — | $499k | 0 |
| HUB CITY ROOTS | Spartanburg | K40 Food, Agriculture & Nutrition | $499k | 0 |
| Folds of Honor Palmetto State Chapter | Simpsonville | B12 Education | $499k | 0 |
| HORRY COUNTY FIRE RESCUE FOUNDATION | Murrells Inlet | M99 Public Safety, Disaster Preparedness & Relief | $499k | 0 |
| TYGER RIVER CHILDRENS CENTER INC | Moore | B20 Education | $498k | 1 |
| CHARLESTON AREA JUSTICE MINISTRY | North Charleston | S21 Community Improvement & Capacity Building | $498k | 2 |
| Neighborhood Outreach Connection | Hilton Head | P80 Human Services | $497k | 5 |
| CHARLESTON ELECTRICAL TRAINING ALLIANCE 776 LOCAL UNION | North Charleston | J22 Employment | $497k | 0 |
| LANCASTER COUNTY CHAMBER OF COMMERCE | Lancaster | S41 Community Improvement & Capacity Building | $497k | 1 |
| DANIEL MADISON FLOYD FOUNDATION | Florence | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $497k | 2 |
| HELP 4 KIDS FLORENCE | Florence | K40 Food, Agriculture & Nutrition | $496k | 0 |
| MARION COUNTY COUNCIL ON AGING | Marion | P81Z Human Services | $496k | 1 |
| CALHOUN ECONOMIC DEVELOPMENT CORPORATION | St Matthews | S30 Community Improvement & Capacity Building | $496k | 0 |
| PROGRESSIVE FAMILY LIFE CENTER | Denmark | P33 Human Services | $495k | 0 |
| Baptist Healthcare System of South Carolina | Columbia | E210 Health Care | $495k | 0 |
| GAMECHANGERS FOUNDATION | North Augusta | X99 Religion-Related | $495k | 0 |
| KYOCERA AVX Components Foundation (fka AVX-Kyocera Foundation) | Fountain Inn | T21Z Philanthropy, Voluntarism & Grantmaking Foundations | $495k | 0 |
| SCANSOURCE CHARITABLE FOUNDATION | Greenville | P20Z Human Services | $495k | 0 |
| THE BEE CAUSE PROJECT INC | Isle Of Palms | B90 Education | $494k | 3 |
| WILLIAM ENSTON HOME CO PARK SMITH | Charleston | L22Z Housing & Shelter | $492k | 1 |
| GREATER GREENVILLE HOCKEY | Greer | N68 Recreation & Sports | $492k | 0 |
| SAMARITAN HEALTH CLINIC OF PICKENS COUNTY | Easley | — | $491k | 3 |
| AMERICAN LEGION AUXILARY OF SC | Columbia | — | $490k | 1 |
| Baskervill Outreach Inc | Pawleys Island | L21Z Housing & Shelter | $490k | 0 |
| FOOTHILLS CHRISTIAN SCHOOL | Westminster | B20 Education | $490k | 0 |
