| THE ILSABABY FOUNDATION | Sullivans Island | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $557k | 0 |
| Greer Christian Learning Center Inc | Greer | B99Z Education | $556k | 0 |
| THE CHAPMAN FAMILY CHARITABLE TRUST C/O SCOTT BOYD | Columbia | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $556k | 0 |
| COLUMBIA INTERNATIONAL FESTIVAL IN | Columbia | A23 Arts, Culture & Humanities | $556k | 0 |
| SOUTHERN INITIATIVE OF THE ALGEBRA PROJECT INC | Summerville | B90 Education | $556k | 1 |
| FLORENCE LITTLE THEATRE | Florence | A650 Arts, Culture & Humanities | $556k | 1 |
| ORANGEBURG-CALHOUN TECHNICAL COLLEGE FOUNDATION INC | Orangeburg | B41Z Education | $556k | 1 |
| THE SANDBOX A HILTON HEAD | Hilton Head Island | A50 Arts, Culture & Humanities | $556k | 0 |
| Asia Wild | Charleston | D30 Animal-Related | $555k | 2 |
| NEW DAY INC OF SPARTANBURG | Spartanburg | — | $555k | 1 |
| LOWER RICHLAND ALUMNI FOUNDATION | Columbia | N12 Recreation & Sports | $555k | 2 |
| DON RYAN CENTER FOR INNOVATION INC | Bluffton | S31 Community Improvement & Capacity Building | $554k | 1 |
| BLACKSBURG VOLUNTEER FIRE DEPARTMEN | Blacksburg | M24 Public Safety, Disaster Preparedness & Relief | $554k | 0 |
| BOYKIN SPANIEL SOCIETY | Rembert | — | $553k | 0 |
| MAG FAMILY FOUNDATION INC | Greenville | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $552k | 0 |
| NATIONAL WILD TURKEY FEDERATION ENDOWMENT FOUNDATION INC | Edgefield | — | $551k | 0 |
| LAURENS COUNTY CHAMBER OF COMMERCE | Laurens | — | $551k | 1 |
| GAMMA NU OF SIGMA CHI HOUSE CORPORATION | Columbia | — | $551k | 0 |
| A Mothers Rest Charitable Respite Foundation | White Rock | P20 Human Services | $550k | 0 |
| FAST FORWARD | Columbia | P20 Human Services | $550k | 1 |
| AIKEN COUNTY HELP LINE INC | Aiken | F40Z Mental Health & Crisis Intervention | $550k | 1 |
| EXCHANGE CLUB OF CHARLESTON | Charleston | — | $550k | 0 |
| FAIR OAK YOUTH CENTER | Fair Play | O20 Youth Development | $549k | 0 |
| FORK SHOALS HISTORICAL SOCIETY | Pelzer | Z99 Unknown | $549k | 0 |
| SOUTH CAROLINA TROOPERS ASSOCIATION INC | Columbia | — | $549k | 0 |
| SUMMERVILLE HIGH SCHOOL ATHLETIC CLUB | Summerville | B12 Education | $549k | 0 |
| VERTICAL LIFT CONSORTIUM INC | Summerville | — | $548k | 0 |
| COLLEGE PANHELLENIC ASSOCIATION | Columbia | N50 Recreation & Sports | $547k | 0 |
| THE PALMETTO PALACE | Johns Island | E99 Health Care | $547k | 0 |
| PICKENS COUNTY HABITAT FOR HUMANITY | Pickens | — | $547k | 1 |
| Sweet Repeat Charitable Foundation | Lake Wylie | T30 Philanthropy, Voluntarism & Grantmaking Foundations | $547k | 0 |
| YMCA OF GREENVILLE FOUNDATION INC | Greenville | N19 Recreation & Sports | $547k | 3 |
| Tara Hall School Inc DBA Mingo Creek Academy | Georgetown | P730 Human Services | $545k | 1 |
| HELPING HANDS NUTRITIONAL SERVICES INC | Aiken | K30Z Food, Agriculture & Nutrition | $545k | 0 |
| UNITED COMMUNITY BANK FOUNDATION | Greenville | T21 Philanthropy, Voluntarism & Grantmaking Foundations | $544k | 0 |
| MIDLAND VALLEY FIRE DEPARTMENT INC | Bath | M24 Public Safety, Disaster Preparedness & Relief | $544k | 0 |
| GREENVILLE URBAN LEAGUE SENIOR HOUSING INC | Columbia | — | $544k | 0 |
| Womens South Carolina Golf Association | Blythewood | N6A Recreation & Sports | $544k | 1 |
| NAGRODSKY FAMILY FOUNDATION | Charleston | T90 Philanthropy, Voluntarism & Grantmaking Foundations | $542k | 0 |
| THE SHEPHERDS FOLD INC | Rock Hill | — | $542k | 0 |
| CHILD ADVOCACY CENTER OF AIKEN COUNTY | Aiken | I72 Crime & Legal-Related | $542k | 0 |
| VANTAGE POINT FOUNDATION | Charleston | — | $541k | 1 |
| UNITED WAY OF OCONEE COUNTY INC | Seneca | T70 Philanthropy, Voluntarism & Grantmaking Foundations | $541k | 1 |
| Lowcountry Food Bank Endowment Fund | Charleston | K11 Food, Agriculture & Nutrition | $540k | 0 |
| POCKETS FULL OF SUNSHINE | Hilton Head | J99 Employment | $540k | 2 |
| WOMEN IN UNITY | Edgefield | P40 Human Services | $539k | 0 |
| CHARLESTON ACADEMY OF MUSIC | Charleston | A68 Arts, Culture & Humanities | $539k | 1 |
| Palmetto Foundation for Prevention and Recovery | Chapin | F20 Mental Health & Crisis Intervention | $539k | 2 |
| OUR DAILY REST INC | Seneca | L41 Housing & Shelter | $538k | 1 |
| LANCASTER SPCA | Lancaster | D20 Animal-Related | $538k | 0 |
