| MICHAEL AND NOEMI NEIDORFF FAMILY FOUNDA | Birmingham | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $12.8M | 5 |
| DOWNTOWN RESCUE MISSION INC | Huntsville | L410 Housing & Shelter | $12.8M | 1 |
| MAEF PUBLIC CHARTER SCHOOLS INC | Mobile | B25 Education | $12.8M | 0 |
| MADISON ACADEMY INC | Madison | — | $12.8M | 1 |
| COUNTRY CLUB OF MOBILE | Mobile | — | $12.7M | 5 |
| GOODWILL INDUSTRIES OF CENTRAL AL | Montgomery | J32Z Employment | $12.7M | 1 |
| AUTOMOTIVE AFTERMARKET ASSOCIATION SOUTHEAST HEALTH FUND | Pike Road | P20 Human Services | $12.7M | 1 |
| THE MONTGOMERY ACADEMY | Montgomery | K200 Food, Agriculture & Nutrition | $12.6M | 2 |
| THE SANDERSON FOUNDATION C/O PHYLLIS FULGHAM | Ethelsville | D12 Animal-Related | $12.6M | 0 |
| ABILITY PLUS INC | Huntsville | P73 Human Services | $12.6M | 6 |
| LEGAL SERVICES ALABAMA INC | Montgomery | I80Z Crime & Legal-Related | $12.6M | 0 |
| MOBILE COUNTY EMERGENCY MEDICAL SERVICES SYSTEM | Semmes | E620 Health Care | $12.6M | 0 |
| ST VINCENT'S BLOUNT | Birmingham | E92Z Health Care | $12.4M | 0 |
| ALABAMA HIGH SCHOOL OF MATHEMATICS AND SCIENCE FOUNDATION | Mobile | B110 Education | $12.3M | 0 |
| Vapor Ministries Inc | Sylacauga | P29 Human Services | $12.1M | 3 |
| FAIRHOPE SINGLE TAX CORPORATION | Fairhope | S990 Community Improvement & Capacity Building | $12.1M | 12 |
| Kings Home Inc | Chelsea | P430 Human Services | $12M | 3 |
| University Charter School | Livingston | B29 Education | $11.9M | 0 |
| AUBURN UNIVERSITY CREDIT UNION | Auburn | — | $11.9M | 3 |
| Henry County Healthcare Authority Inc | Abbevile | E910 Health Care | $11.7M | 1 |
| THE ARC OF MADISON COUNTY INC | Huntsville | — | $11.6M | 3 |
| MARSHALL-JACKSON MENTAL HEALTH BOARD INC | Guntersville | F30Z Mental Health & Crisis Intervention | $11.6M | 5 |
| THE BLACK BELT COMMUNITY FOUNDATION INC | Selma | T31 Philanthropy, Voluntarism & Grantmaking Foundations | $11.5M | 3 |
| ALATRUST CREDIT UNION | Hoover | — | $11.4M | 4 |
| Propel Education | Birmingham | J20 Employment | $11.4M | 9 |
| UNIVERSITY OF SOUTH ALABAMA FOUNDATION | Mobile | B110 Education | $11.3M | 3 |
| JOHN KNOX MANOR INC | Montgomery | E91 Health Care | $11.3M | 3 |
| CORNERSTONE SCHOOLS OF ALABAMA INC | Birmingham | — | $11.3M | 2 |
| ALABAMA CENTRAL CREDIT UNION | Birmingham | — | $11.2M | 3 |
| GEORGIA-ALABAMA LAND TRUST INC | Piedmont | C340 Environment | $11.2M | 3 |
| UNIVERSITY OF NORTH ALABAMA FOUNDATION | Florence | B110 Education | $11.2M | 1 |
| DOULOS PARTNERS | Birmingham | Q33 International, Foreign Affairs & National Security | $11.1M | 2 |
| LAKESHORE FOUNDATION | Birmingham | E22Z Health Care | $11.1M | 7 |
| HOSPICE OF WEST ALABAMA INC | Tuscaloosa | P74Z Human Services | $11.1M | 4 |
| FREEDOM RAIN INC | Birmingham | P51 Human Services | $11M | 3 |
| COMMUNITY ACTION AGENCY OF SOUTH ALABAMA INC | Daphne | — | $11M | 0 |
| FORT MCCLELLAN CREDIT UNION | Anniston | — | $10.9M | 4 |
| UNIVERSITY OF MONTEVALLO FOUNDATION | Montevallo | B43I Education | $10.9M | 1 |
| NATIONAL CHILDREN'S ADVOCACY CENTER INC | Huntsville | — | $10.9M | 5 |
| FRANKLIN ELECTRIC COOPERATIVE | Russellville | — | $10.9M | 10 |
| LEE SCOTT ACADEMY INC | Auburn | — | $10.8M | 4 |
| YOUNG MEN'S CHRISTIAN ASSOCIATION OF METROPOLITAN HUNTSVILLE ALABAMA | Madison | P270 Human Services | $10.8M | 2 |
| LEE COUNTY YOUTH DEVELOPMENT CENTER | Opelika | I440 Crime & Legal-Related | $10.6M | 0 |
| American Christian Ed Assoc Inc | Tuscaloosa | — | $10.4M | 0 |
| Legacy Schools | Birmingham | B29 Education | $10.4M | 0 |
| UNITED STATES HEALTH & HOUSING | Ozark | E91Z Health Care | $10.4M | 7 |
| THE HUNTSVILLE HOSPITAL FOUNDATIONINC | Huntsville | E112 Health Care | $10.3M | 1 |
| NEW SCHOOLS FOR ALABAMA | Birmingham | B03 Education | $10.3M | 5 |
| CENTRAL NORTH AL HEALTH SERVICE INC | Huntsville | E39Z Health Care | $10.2M | 0 |
| CAPSTONE HEALTH | Parrish | E30 Health Care | $10.1M | 7 |
