| REACH RIVERSIDE DEVELOPMENT CORP | Wilmington | L20 Housing & Shelter | $10.3M | 4 |
| MILFORD HOUSING DEVELOPMENT CORP | Milford | L210 Housing & Shelter | $10.3M | 0 |
| The Synopsys Foundation | Wilmington | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $10.2M | 0 |
| Dominique-Jean Larrey Foundation | Wilmington | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $10.2M | 0 |
| DELAWARE BAR FOUNDATION | Wilmington | I128 Crime & Legal-Related | $10.1M | 1 |
| The RAATT DeJong Family Foundation | Wilmington | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $10.1M | 0 |
| LONGVIEW PHILANTHROPY USA INC | Claymont | T05 Philanthropy, Voluntarism & Grantmaking Foundations | $10M | 5 |
| DELAWARE INNOVATION SPACE INC | Wilmington | S40 Community Improvement & Capacity Building | $10M | 4 |
| THE MINISTRY OF CARING INC | Wilmington | — | $10M | 2 |
| CHRISTIANA FIRE COMPANY INC | Christiana | — | $9.9M | 2 |
| MID-ATLANTIC REGION COMMISSION ON HIGHER | Wilmington | B90 Education | $9.9M | 8 |
| REHOBOTH BEACH COUNTRY CLUB | Rehoboth Beach | — | $9.8M | 9 |
| FRIENDS OF DUCK CREEK REGIONAL | Smyrna | O20 Youth Development | $9.8M | 0 |
| Westminster Barrington Foundation | Wilmington | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $9.7M | 0 |
| The Georges J Daou Foundation | Wilmington | — | $9.6M | 0 |
| The Tijori Foundation | Wilmington | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $9.6M | 2 |
| OPPORTUNITY CENTER INC | New Castle | — | $9.6M | 13 |
| Eleutherian Mills-Hagley Foundation Inc | Wilmington | A540 Arts, Culture & Humanities | $9.6M | 5 |
| JOHN M PAZ FDN 12 23 10 JOHN M PAZ & BBHTCDE | Wilmington | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $9.6M | 1 |
| Foundation for Truth Justice and Compassion | Wilmington | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $9.6M | 0 |
| The Linda and Mike Mussallem Foundation | Wilmington | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $9.5M | 0 |
| Tom Russell Charitable Foundation Inc | Wilmington | — | $9.4M | 4 |
| THE BERNARD AND RUTH SIEGEL JEWISH | Wilmington | — | $9.4M | 3 |
| COMMUNITY LEGAL AID SOCIETY INC | Wilmington | I83Z Crime & Legal-Related | $9.3M | 7 |
| COMMUNITY EDUCATION BUILDING CORP | Wilmington | T23 Philanthropy, Voluntarism & Grantmaking Foundations | $9.2M | 1 |
| PLANNED PARENTHOOD DIRECT INC | Wilmington | E19 Health Care | $9.1M | 10 |
| The Dunn Foundation | Wilmington | — | $9.1M | 2 |
| INGLESIDE HOMES INC | Wilmington | P750 Human Services | $8.8M | 4 |
| The Lillian J Schauer Foundation | Wilmington | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $8.7M | 1 |
| DELAWARE MILITARY ACADEMY | Wilmington | B29 Education | $8.7M | 4 |
| The FJK Private Foundation | Wilmington | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $8.7M | 0 |
| FIRST STATE COMMUNITY ACTION AGENCY | Georgetown | — | $8.6M | 1 |
| COMMANDERIE D'AMERIQUE DE LA CONFRERIE | Dover | N50 Recreation & Sports | $8.5M | 0 |
| Workday Foundation | Wilmington | T21 Philanthropy, Voluntarism & Grantmaking Foundations | $8.5M | 0 |
| Shiff Family Foundation | Wilmington | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $8.4M | 0 |
| EARLY COLLEGE SCHOOL AT DELAWARE | Dover | B25 Education | $8.4M | 4 |
| NEWARK EMERGENCY CENTER INC | Newark | E63Z Health Care | $8.4M | 15 |
| Burnham Family Foundation | Wilmington | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $8.3M | 0 |
| Jean T and Heyward G Pelham Foundation | Wilmington | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $8.3M | 0 |
| John and Julie Schmidt Family Foundation | Wilmington | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $8.3M | 0 |
| ACADEMY OF DOVER CHARTER SCHOOL | Dover | B20 Education | $8.3M | 2 |
| PEOPLE'S PLACE II INC | Milford | P200 Human Services | $8.3M | 5 |
| SUSSEX COUNTY HABITAT FOR HUMANITY | Georgetown | — | $8.2M | 1 |
| DOERS NETWORK INC | Wilmington | — | $8.2M | 0 |
| EMMET FAMILY CHARITABLE FOUNDATION | Newark | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $8.2M | 2 |
| NEW CASTLE COUNTY HEAD START INC | Newark | — | $8.2M | 1 |
| RODEL CHARITABLE FOUNDATION - DE | Wilmington | T11 Philanthropy, Voluntarism & Grantmaking Foundations | $8.1M | 5 |
| Mount Holly Charitable Foundation | Wilmington | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $8.1M | 0 |
| LATIN AMERICAN COMMUNITY | Wilmington | P28Z Human Services | $8.1M | 1 |
| The Michael and Karen Stone Family Foundation | Wilmington | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $8M | 0 |
