| Robert and Ardis James Foundation Inc | Wilmington | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $14M | 0 |
| Earl and Kathryn Congdon Family Foundation | Wilmington | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $13.7M | 0 |
| MARY JANE AND CARL PANATTONI CHARITABLE | Wilmington | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $13.6M | 0 |
| PLUMBERS & PIPEFITTERS LOCAL UNION | Wilmington | — | $13.6M | 0 |
| Horizon Charitable Foundation | Wilmington | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $13.5M | 0 |
| The Giving Bee Family Foundation | Wilmington | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $13.4M | 0 |
| HOME FOR AGED WOMEN-MINQUADALE HOME | Wilmington | P750 Human Services | $13.3M | 6 |
| The Efrusy Family Foundation | Wilmington | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $13.2M | 0 |
| S & L Marx Foundation | Wilmington | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $13.2M | 1 |
| DELAWARE LIFE & HEALTH INSURANCE | Newark | — | $13.2M | 0 |
| AMERICAN COOPERATIVE SCHOOL OF TUNIS | Wilmington | B20 Education | $13.1M | 4 |
| The Kendeda Fund | Wilmington | — | $13.1M | 1 |
| THE D LANE & ANWYL BATES FOUNDATION | Wilmington | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $13.1M | 2 |
| Kentmere Rehabilitation and Skilled Nursing | Wilmington | P750 Human Services | $13.1M | 7 |
| DELMARVA CHRISTIAN SCHOOLS INC | Georgetown | B25 Education | $13M | 0 |
| THREE SISTERS FOUNDATION | Wilmington | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $12.9M | 1 |
| Homer Skelton Charitable Foundation | Wilmington | B82Z Education | $12.9M | 0 |
| The White Horse Group Foundation Inc | Wilmington | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $12.8M | 0 |
| The Brady Foundation | Wilmington | — | $12.5M | 0 |
| CARAVEL ACADEMY INC | Bear | B200 Education | $12.3M | 2 |
| THE MODERN MATURITY CENTER INC | Dover | P81Z Human Services | $12.3M | 4 |
| THE INDEPENDENCE SCHOOL INC | Newark | — | $12.3M | 4 |
| AURORA FOUNDATION | Wilmington | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $12.2M | 1 |
| MacKenzie Ryan Brumberg Foundation | Wilmington | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $12M | 0 |
| Local Independent Online News Publishers Inc | Wilmington | A03 Arts, Culture & Humanities | $11.8M | 8 |
| THE DELAWARE STATE FAIR INC | Harrington | N52 Recreation & Sports | $11.6M | 3 |
| The Herbert & Nell Singer Foundation Inc | Wilmington | — | $11.6M | 2 |
| Edris Charitable Foundation | Wilmington | P99 Human Services | $11.3M | 0 |
| KINGSWOOD COMMUNITY CENTER INC | Wilmington | P28Z Human Services | $11.3M | 4 |
| MOISE Y SAFRA FOUNDATION INC | Wilmington | T23 Philanthropy, Voluntarism & Grantmaking Foundations | $11.3M | 0 |
| FREIRE CHARTER SCHOOL WILMINGTON INC | Wilmington | B29 Education | $11.2M | 2 |
| The Margaret Ellen Nielsen Foundation | Wilmington | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $11.1M | 0 |
| FIRST STATE MONTESSORI ACADEMY | Wilmington | B20 Education | $11M | 3 |
| WRLD Foundation | Wilmington | C12 Environment | $11M | 1 |
| The Raphael Family Foundation | Wilmington | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $10.9M | 0 |
| THE ANDREW MCDONOUGH B FOUNDATION | Wilmington | E12 Health Care | $10.9M | 3 |
| THE PROVIDENCE CREEK ACADEMY | Clayton | B29 Education | $10.9M | 2 |
| EASTSIDE CHARTER SCHOOL | Wilmington | B82Z Education | $10.9M | 8 |
| NEIGHBORGOOD PARTNERS INC | Dover | K20Z Food, Agriculture & Nutrition | $10.8M | 1 |
| The JADES Foundation | Wilmington | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $10.8M | 0 |
| INTERCOLLEGIATE STUDIES INSTITUTE INC | Wilmington | B40Z Education | $10.7M | 6 |
| AIDS DELAWARE INC | Wilmington | E00A Health Care | $10.7M | 1 |
| THE MARY PARKER FOUNDATION 157823-000 | Wilmington | — | $10.7M | 3 |
| The Whitcomb Family Foundation Inc | Wilmington | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $10.7M | 0 |
| CHEER INC | Georgetown | P810 Human Services | $10.6M | 3 |
| COLLIN AND JOANNA ROCHE FAMILY FOUNDATION | Wilmington | — | $10.6M | 0 |
| THE VALOUR FOUNDATION | Dover | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $10.5M | 0 |
| The Jeffrey L Greenblum Charitable | Wilmington | — | $10.5M | 0 |
| The Schmetterling Foundation | Wilmington | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $10.4M | 0 |
| THE MAX STENBECK FOUNDATION | Wilmington | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $10.3M | 0 |
