| Kuumba Academy Charter School Inc | Wilmington | B29 Education | $15.4M | 2 |
| JOSHUA M FREEMAN FOUNDATION | Selbyville | A60 Arts, Culture & Humanities | $15.3M | 5 |
| The DeLuca Family Foundation | Wilmington | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $15.3M | 0 |
| DELAWARE STATE UNIVERSITY FOUNDATION INC | Dover | B11 Education | $15.1M | 3 |
| BUILDING DECARBONIZATION COALITION | Lewes | C01 Environment | $15M | 18 |
| LA RED HEALTH CENTER INC | Georgetown | E30 Health Care | $14.8M | 10 |
| The Monarch Charitable Foundation aka THE MONARCH FOUNDATION | Wilmington | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $14.7M | 0 |
| PLUMBERS & PIPEFITTERS LOCAL UNION 74 WELFARE FUND | Wilmington | — | $14.5M | 0 |
| JK Family Charitable Foundation | Wilmington | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $14.5M | 0 |
| Kentmere Rehabilitation and Skilled Nursing Inc | Wilmington | P750 Human Services | $14.2M | 5 |
| Louis and Anne Abrons Foundation Inc | Wilmington | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $14M | 0 |
| Kelleher Family Foundation | Wilmington | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $14M | 0 |
| Robert and Ardis James Foundation Inc | Wilmington | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $14M | 0 |
| EASTSIDE CHARTER SCHOOL | Wilmington | B82Z Education | $13.8M | 6 |
| Eleutherian Mills-Hagley Foundation Inc | Wilmington | A540 Arts, Culture & Humanities | $13.8M | 8 |
| Earl and Kathryn Congdon Family Foundation | Wilmington | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $13.7M | 0 |
| MARY JANE AND CARL PANATTONI CHARITABLE | Wilmington | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $13.6M | 0 |
| HAMPSHIRE FOUNDATION INC | Wilmington | K20 Food, Agriculture & Nutrition | $13.5M | 1 |
| American Electric Power Foundation | Wilmington | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $13.5M | 0 |
| AMERICAN COOPERATIVE SCHOOL OF TUNIS ASSOCIATION | Wilmington | B20 Education | $13.4M | 7 |
| HOME FOR AGED WOMEN-MINQUADALE HOME INC | Wilmington | P750 Human Services | $13.3M | 6 |
| The Efrusy Family Foundation | Wilmington | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $13.2M | 0 |
| S & L Marx Foundation | Wilmington | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $13.2M | 1 |
| DELAWARE LIFE & HEALTH INSURANCE GUARANTY ASSOCIATION | Newark | — | $13.2M | 0 |
| The Kendeda Fund | Wilmington | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $13.1M | 1 |
| DELMARVA CHRISTIAN SCHOOLS INC | Georgetown | B25 Education | $13M | 0 |
| Homer Skelton Charitable Foundation | Wilmington | B82Z Education | $12.9M | 0 |
| AEC Trust | Wilmington | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $12.9M | 1 |
| Afeyan Family Foundation | Wilmington | T21 Philanthropy, Voluntarism & Grantmaking Foundations | $12.9M | 0 |
| BEEBE MEDICAL FOUNDATION | Lewes | E110 Health Care | $12.6M | 5 |
| COMMUNITY LEGAL AID SOCIETY INC | Wilmington | I83Z Crime & Legal-Related | $12.5M | 7 |
| The Brady Foundation | Wilmington | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $12.5M | 0 |
| Baracker Flynn Foundation | Wilmington | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $12.4M | 2 |
| CARAVEL ACADEMY INC | Bear | B200 Education | $12.3M | 2 |
| THE MODERN MATURITY CENTER INC | Dover | P81Z Human Services | $12.3M | 4 |
| Poole Family Charitable Foundation | Wilmington | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $12.1M | 0 |
| MacKenzie Ryan Brumberg Foundation | Wilmington | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $12M | 0 |
| Local Independent Online News Publishers Inc | Wilmington | A03 Arts, Culture & Humanities | $11.8M | 8 |
| THE DELAWARE STATE FAIR INC | Harrington | N52 Recreation & Sports | $11.6M | 3 |
| THE INDEPENDENCE SCHOOL INC | Newark | — | $11.6M | 6 |
| ARIEL UNIVERSITY FOUNDATION | Middletown | B82 Education | $11.6M | 0 |
| The Herbert & Nell Singer Foundation Inc | Wilmington | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $11.6M | 2 |
| KINGSWOOD COMMUNITY CENTER INC | Wilmington | P28Z Human Services | $11.3M | 4 |
| MID-ATLANTIC REGION COMMISSION ON HIGHER EDUCATION | Wilmington | B90 Education | $11.1M | 8 |
| The Margaret Ellen Nielsen Foundation | Wilmington | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $11.1M | 0 |
| FIRST STATE MONTESSORI ACADEMY | Wilmington | B20 Education | $11M | 3 |
| WRLD Foundation | Wilmington | C12 Environment | $11M | 1 |
| The Raphael Family Foundation | Wilmington | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $10.9M | 0 |
| THE ANDREW MCDONOUGH B FOUNDATION | Wilmington | E12 Health Care | $10.9M | 3 |
| THE PROVIDENCE CREEK ACADEMY CHARTER SCHOOL INC | Clayton | B29 Education | $10.9M | 2 |
