| DELAWARE ART MUSEUM INC | Wilmington | A510 Arts, Culture & Humanities | $6.3M | 2 |
| CRYSTAL TRUST | Montchanin | — | $6.3M | 1 |
| CHARTER SCHOOL INC | Dover | B99Z Education | $6.3M | 3 |
| Voorhis Foundation | Wilmington | T12 Philanthropy, Voluntarism & Grantmaking Foundations | $6.2M | 0 |
| THE LIFE HEALTH CENTER COMPLEX INC | Wilmington | E30 Health Care | $6.2M | 2 |
| EJK Foundation | Wilmington | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $6.2M | 1 |
| KAIROS PHILANTHROPY FUND | Wilmington | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $6.1M | 0 |
| JHC Foundation | Wilmington | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $6.1M | 0 |
| FIRST COMMUNITY FOUNDATION | Wilmington | L11 Housing & Shelter | $6M | 3 |
| IMPROVE THE NEWS FOUNDATION | New Castle | A30 Arts, Culture & Humanities | $5.9M | 0 |
| The Deerfield Partnership Foundation | Wilmington | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $5.9M | 1 |
| American Electric Power Foundation | Wilmington | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $5.9M | 0 |
| Way Foundation Inc | Wilmington | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $5.8M | 0 |
| The Woody Family Foundation | Wilmington | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $5.8M | 0 |
| UNRIG OUR ECONOMY INC | Wilmington | — | $5.8M | 0 |
| LEWES FIRE DEPARTMENT INC | Lewes | M24 Public Safety, Disaster Preparedness & Relief | $5.8M | 0 |
| MAJIC Vermont Foundation | Wilmington | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $5.7M | 0 |
| THE LORELTON FOUNDATION | Wilmington | — | $5.7M | 1 |
| Diodes Foundation | Wilmington | B99 Education | $5.7M | 0 |
| THE GREATER LEWES FOUNDATION | Lewes | C34 Environment | $5.7M | 0 |
| The Ruth & J O Stone Foundation | Wilmington | T99 Philanthropy, Voluntarism & Grantmaking Foundations | $5.6M | 0 |
| Courtney Christian Charitable Foundation | Wilmington | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $5.6M | 0 |
| Pincus Family Foundation | Wilmington | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $5.6M | 0 |
| The Carol Moss Foundation | Wilmington | — | $5.6M | 7 |
| The Nemec Abbott Foundation | Wilmington | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $5.6M | 0 |
| DEL-MAR-VA COUNCIL INC | Dover | — | $5.6M | 2 |
| Al King Family Foundation | Wilmington | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $5.5M | 0 |
| MID ATLANTIC CLEAN HYDROGEN HUB INC | Dover | U12 Science & Technology | $5.5M | 3 |
| SMILOW FOUNDATION | Wilmington | — | $5.5M | 4 |
| The Anthony and Susan Consigli | Wilmington | P99 Human Services | $5.5M | 0 |
| WEINGARTEN FOUNDATION | Wilmington | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $5.5M | 1 |
| Charles R Wood Foundation | Wilmington | — | $5.5M | 0 |
| Oechsle Family Foundation Inc | Wilmington | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $5.5M | 0 |
| Kevin M Jones Foundation Trust | Wilmington | T90 Philanthropy, Voluntarism & Grantmaking Foundations | $5.4M | 2 |
| The Silseth Foundation | Wilmington | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $5.4M | 0 |
| LITTLE SISTERS OF THE POOR INC | Newark | L22Z Housing & Shelter | $5.4M | 3 |
| Sierra Pine Family Foundation | Wilmington | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $5.3M | 0 |
| Broadcom Foundation | Wilmington | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $5.3M | 2 |
| THE GORDON AND JENNY SINGER FOUNDATION | Wilmington | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $5.3M | 0 |
| FREEMAN ARTS PAVILION INC | Selbyville | A11 Arts, Culture & Humanities | $5.2M | 1 |
| F R BABCOCKBABCOCK UROLOGICAL ENDOW FD | Wilmington | B11 Education | $5.2M | 1 |
| PLANNED PARENTHOOD OF DELAWARE INC | Wilmington | E420 Health Care | $5.2M | 3 |
| The Jewell Foundation | Wilmington | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $5.2M | 0 |
| RAJAM FAMILY FOUNDATION | Wilmington | — | $5.2M | 0 |
| YWCA DELAWARE INC | Wilmington | P270 Human Services | $5.1M | 2 |
| PV Benevolence Foundation | Wilmington | P20 Human Services | $5.1M | 0 |
| Frank McHugh-O'Donovan Foundation Inc | Wilmington | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $5.1M | 0 |
| CHILDREN'S BEACH HOUSE INC | Wilmington | — | $5.1M | 3 |
| INTERNATIONAL FOUNDATION FOR VALUING IMPACTS INC | Dover | V22 Social Science | $5.1M | 5 |
| The Look and See Foundation | Wilmington | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $5M | 0 |
