| GATEWAY CHARTER SCHOOL | Wilmington | B29 Education | $5M | 5 |
| RUTH LILLY FOUNDATION | Wilmington | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $5M | 5 |
| Autism Delaware Inc | Newark | G84 Diseases, Disorders & Medical Disciplines | $5M | 1 |
| Firstfruits and Seeds Foundation | Wilmington | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $5M | 0 |
| The Foxwynd Foundation | Wilmington | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $5M | 0 |
| STK Foundation | Wilmington | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $5M | 0 |
| Boswell's Fund | Wilmington | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $5M | 0 |
| Nancy and Craig Stoller Family Foundation | Wilmington | — | $5M | 0 |
| GE Vernova Foundation I | Wilmington | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $5M | 0 |
| THE CEDARCREST CHARITABLE FOUNDATION AKA | Wilmington | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $5M | 0 |
| CHRISTINA CULTURAL ARTS CENTER INC | Wilmington | A610 Arts, Culture & Humanities | $5M | 1 |
| David & Janet Polak Foundation | Wilmington | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $4.9M | 1 |
| WELFARE FOUNDATION INC | Wilmington | — | $4.9M | 1 |
| FAITHFUL FRIENDS INC | New Castle | D20 Animal-Related | $4.9M | 3 |
| DELAWARE COLLEGE OF ART AND DESIGN | Wilmington | A60Z Arts, Culture & Humanities | $4.9M | 2 |
| WILMINGTON HEAD START INC | Wilmington | Z99 Unknown | $4.8M | 1 |
| LISA DEAN MOSELEY FOUNDATION | Rockland | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $4.8M | 0 |
| 2-4-3 Foundation | Wilmington | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $4.8M | 0 |
| JOBS FOR DELAWARE GRADUATES INC | Dover | J200 Employment | $4.8M | 2 |
| DELAWARE STANDARDBRED OWNERS | Dover | — | $4.8M | 1 |
| Tseng-Rust Family Foundation | Wilmington | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $4.8M | 0 |
| IMPACT LIFE INC | Hockessin | F01 Mental Health & Crisis Intervention | $4.7M | 1 |
| ST MICHAEL'S SCHOOL AND NURSERY INC | Wilmington | — | $4.7M | 1 |
| Reiner Family Foundation | Wilmington | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $4.7M | 0 |
| M K Reichert Sternlicht Foundation | Wilmington | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $4.7M | 0 |
| THE SINGER FAMILY CHARITABLE FOUNDATION | Wilmington | — | $4.6M | 0 |
| POLICE ATHLETIC LEAGUE OF DELAWARE INC | Hockessin | — | $4.6M | 1 |
| TRUE ACCESS CAPITAL CORPORATION | Wilmington | W60Z Public & Societal Benefit | $4.6M | 2 |
| GoodwillFinds Ecommerce Inc | Wilmington | — | $4.6M | 7 |
| TECKS Foundation | Wilmington | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $4.6M | 0 |
| William J Butler Foundation Inc | Wilmington | — | $4.6M | 0 |
| NETWORK CONNECT INC | Wilmington | O50 Youth Development | $4.6M | 1 |
| REHOBOTH BEACH VOLUNTEER FIRE | Rehoboth Beach | M24 Public Safety, Disaster Preparedness & Relief | $4.6M | 0 |
| Cunningham Family Foundation | Wilmington | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $4.5M | 0 |
| Dallas Morse Coors Foundation for the | Wilmington | — | $4.5M | 0 |
| SONECHA FAMILY FOUNDATION | Newark | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $4.5M | 0 |
| GREAT OAKS CHARTER SCHOOL - | Wilmington | B25 Education | $4.4M | 1 |
| CARLISLE FIRE COMPANY INC | Milford | — | $4.4M | 0 |
| ELIZABETH W MURPHEY SCHOOL INC | Dover | — | $4.4M | 1 |
| DeNardo Education and | Camden | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $4.4M | 0 |
| WILMINGTON NEIGHBORHOOD CONSERVANCY LAND | Wilmington | S20 Community Improvement & Capacity Building | $4.4M | 1 |
| The Tinybell Charitable Fund | Wilmington | T01 Philanthropy, Voluntarism & Grantmaking Foundations | $4.4M | 0 |
| THE OWASP FOUNDATION INC | Wilmington | U41 Science & Technology | $4.3M | 2 |
| LEGAL SERVICES CORP OF DELAWARE | Wilmington | I80 Crime & Legal-Related | $4.3M | 6 |
| The Jennifer and Walker Royall Family | Wilmington | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $4.3M | 0 |
| MILL CREEK FIRE COMPANY INC | Wilmington | M24Z Public Safety, Disaster Preparedness & Relief | $4.3M | 0 |
| Winslow Foundation | Wilmington | — | $4.2M | 1 |
| LIMEN HOUSE INC | Wilmington | — | $4.2M | 3 |
| Walder Foundation | Wilmington | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $4.2M | 2 |
| LOCAL JOBS & ECONOMIC DEVELOPMENT FUND INC | Dover | — | $4.2M | 0 |
