| CHRISTIANA CARE HEALTH INITIATIVES INC | Wilmington | E500 Health Care | $4.8M | 8 |
| Tseng-Rust Family Foundation | Wilmington | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $4.8M | 0 |
| The FJK Private Foundation | Wilmington | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $4.8M | 0 |
| FLYGATEWAY AVIATION INSTITUTE | New Castle | B50 Education | $4.7M | 0 |
| ST MICHAEL'S SCHOOL AND NURSERY INC | Wilmington | — | $4.7M | 1 |
| Reiner Family Foundation | Wilmington | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $4.7M | 0 |
| M K Reichert Sternlicht Foundation | Wilmington | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $4.7M | 0 |
| James S and Gail P Riepe Charitable Foundation | Wilmington | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $4.6M | 0 |
| TRUE ACCESS CAPITAL CORPORATION | Wilmington | W60Z Public & Societal Benefit | $4.6M | 2 |
| GoodwillFinds Ecommerce Inc | Wilmington | — | $4.6M | 7 |
| Voorhis Foundation | Wilmington | T12 Philanthropy, Voluntarism & Grantmaking Foundations | $4.6M | 0 |
| NETWORK CONNECT INC | Wilmington | O50 Youth Development | $4.6M | 1 |
| Roy and Gwen Steeley Foundation Inc | Wilmington | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $4.6M | 2 |
| REHOBOTH BEACH VOLUNTEER FIRE COMPANY INC | Rehoboth Beach | M24 Public Safety, Disaster Preparedness & Relief | $4.6M | 0 |
| Cunningham Family Foundation | Wilmington | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $4.5M | 0 |
| Bauer Family Foundation | Wilmington | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $4.5M | 0 |
| The Aiko Foundation | Wilmington | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $4.5M | 0 |
| SONECHA FAMILY FOUNDATION | Newark | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $4.5M | 0 |
| CARLISLE FIRE COMPANY INC | Milford | — | $4.4M | 0 |
| ELIZABETH W MURPHEY SCHOOL INC | Dover | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $4.4M | 1 |
| Steadfast Initiative Fund | Wilmington | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $4.4M | 0 |
| DeNardo Education and Research Foundation | Camden | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $4.4M | 0 |
| RONALD MCDONALD HOUSE CHARITIES OF GREATER DELAWARE INC | Wilmington | — | $4.4M | 1 |
| WILMINGTON NEIGHBORHOOD CONSERVANCY LAND BANK CORPORATION | Wilmington | S20 Community Improvement & Capacity Building | $4.4M | 1 |
| The Sye Fund | Wilmington | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $4.4M | 0 |
| TUSO | Wilmington | B11 Education | $4.4M | 2 |
| THE OWASP FOUNDATION INC | Wilmington | U41 Science & Technology | $4.3M | 2 |
| LEGAL SERVICES CORP OF DELAWARE | Wilmington | I80 Crime & Legal-Related | $4.3M | 6 |
| VOLUNTEER HOSE COMPANY OF MIDDLETOWN | Middletown | M24Z Public Safety, Disaster Preparedness & Relief | $4.3M | 0 |
| ANDREW AND COREY MORRIS-SINGER FOUNDATION | Wilmington | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $4.3M | 0 |
| FIRST COMMUNITY FOUNDATION F/K/A EASTSIDE COMMUNITY LEARNING CENTER | Wilmington | L11 Housing & Shelter | $4.3M | 2 |
| Michael and Andrea Leven Family Foundation | Wilmington | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $4.3M | 0 |
| Winslow Foundation | Wilmington | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $4.2M | 1 |
| LIMEN HOUSE INC | Wilmington | — | $4.2M | 3 |
| NEWARK SENIOR CENTER INC | Newark | P81Z Human Services | $4.2M | 2 |
| Horizon Charitable Foundation | Wilmington | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $4.2M | 0 |
| POSITIVE OUTCOMES CHARTER SCHOOL | Camden | B200 Education | $4.1M | 3 |
| CHRISTINA CULTURAL ARTS CENTER INC | Wilmington | A610 Arts, Culture & Humanities | $4.1M | 2 |
| WILMINGTON MONTESSORI SCHOOL INC | Wilmington | B21Z Education | $4.1M | 4 |
| BETTER NEXT YEAR FUND | Dover | — | $4.1M | 0 |
| Spector Family Foundation | Wilmington | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $4.1M | 0 |
| DELAWARE BAY AND RIVER COOPERATIVE INC | Lewes | C32 Environment | $4.1M | 5 |
| Foerster Bernstein Foundation | Wilmington | Z99 Unknown | $4M | 0 |
| Towanda Foundation | Wilmington | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $4M | 0 |
| Rhoda Trabulsi Foundation | Wilmington | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $4M | 0 |
| DELAWARE NATURE SOCIETY INC | Hockessin | C600 Environment | $4M | 2 |
| TALLEYVILLE FIRE COMPANY INC | Wilmington | — | $4M | 0 |
| JOE AND JILL BIDEN PRESIDENTIAL LIBRARY FOUNDATION | Wilmington | B70 Education | $4M | 0 |
| DORY FOUNDATION | Dover | T12 Philanthropy, Voluntarism & Grantmaking Foundations | $4M | 0 |
| Schmenk Family Foundation | Wilmington | W99 Public & Societal Benefit | $4M | 0 |
