| RIVERFRONT DEVELOPMENT CORPORATION | Wilmington | S300 Community Improvement & Capacity Building | $4.1M | 2 |
| POSITIVE OUTCOMES CHARTER SCHOOL | Camden | B200 Education | $4.1M | 3 |
| RAYNIER INSTITUTE & FOUNDATION | Wilmington | — | $4.1M | 0 |
| WILMINGTON MONTESSORI SCHOOL INC | Wilmington | B21Z Education | $4.1M | 4 |
| Spector Family Foundation | Wilmington | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $4.1M | 0 |
| DELAWARE BAY AND RIVER COOPERATIVE INC | Lewes | C32 Environment | $4.1M | 5 |
| Foerster Bernstein Foundation | Wilmington | Z99 Unknown | $4M | 0 |
| Towanda Foundation | Wilmington | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $4M | 0 |
| Rhoda Trabulsi Foundation | Wilmington | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $4M | 0 |
| DELAWARE NATURE SOCIETY INC | Hockessin | C600 Environment | $4M | 2 |
| TALLEYVILLE FIRE COMPANY INC | Wilmington | — | $4M | 0 |
| WILMINGTON INSTITUTE FREE LIBRARY | Wilmington | — | $4M | 1 |
| DORY FOUNDATION | Dover | T12 Philanthropy, Voluntarism & Grantmaking Foundations | $4M | 0 |
| Schmenk Family Foundation | Wilmington | W99 Public & Societal Benefit | $4M | 0 |
| MILLVILLE VOLUNTEER FIRE CO INC | Millville | M24 Public Safety, Disaster Preparedness & Relief | $4M | 0 |
| Sylvan H Kline Family Foundation | Wilmington | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $3.9M | 0 |
| UNION HOSPITAL OF CECIL COUNTY HEALTH | Willmington | E32Z Health Care | $3.9M | 3 |
| TRUST UA PHILIP F DUPONT FBO UNIVERSITY | Wilmington | B110 Education | $3.9M | 0 |
| CHRISTIANA CARE HEALTH INITIATIVES INC | Wilmington | E500 Health Care | $3.9M | 8 |
| TRUSTEES OF THE NEW CASTLE COMMON | New Castle | S220 Community Improvement & Capacity Building | $3.9M | 0 |
| HUMANE ANIMAL PARTNERS | Wilmington | D20 Animal-Related | $3.9M | 5 |
| The Prentice Foundation Inc | Wilmington | — | $3.9M | 0 |
| HEAD & HEART FOUNDATION TR 12319 | Wilmington | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $3.8M | 1 |
| PARTNERSHIP FOR THE DELAWARE | Wilmington | C30 Environment | $3.8M | 2 |
| MILLSBORO FIRE COMPANY INC | Millsboro | M24 Public Safety, Disaster Preparedness & Relief | $3.8M | 0 |
| Robinson Foundation | Wilmington | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $3.8M | 2 |
| Westmeath Foundation | Wilmington | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $3.7M | 2 |
| The ZAC Foundation for Children's Safety | Wilmington | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $3.7M | 0 |
| Maud and Burton Goldfield Family Foundation | Wilmington | T19 Philanthropy, Voluntarism & Grantmaking Foundations | $3.7M | 0 |
| Valley Fund Charitable Foundation | Wilmington | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $3.7M | 0 |
| CENTREVILLE LAYTON SCHOOL | Centreville | B280 Education | $3.7M | 3 |
| COLLEGIATE NETWORK INC | Wilmington | A33 Arts, Culture & Humanities | $3.7M | 1 |
| VOLUNTEER HOSE COMPANY OF MIDDLETOWN | Middletown | M24Z Public Safety, Disaster Preparedness & Relief | $3.7M | 0 |
| Roy and Gwen Steeley Foundation Inc | Wilmington | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $3.6M | 2 |
| HARRISON HOUSE COMMUNITY PROGRAMS | New Castle | O99Z Youth Development | $3.6M | 2 |
| The Ramesh and Kalpana Bhatia Family | Wilmington | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $3.6M | 2 |
| DELAWARE HIV SERVICES INC | Wilmington | — | $3.6M | 1 |
| RUSSELL COLGATE FUND INC | Wilmington | — | $3.6M | 0 |
| GIRL SCOUTS OF CHESAPEAKE BAY COUNCIL | Hockessin | O42Z Youth Development | $3.6M | 2 |
| THE ALORA CHARITABLE FOUNDATION | Dover | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $3.6M | 0 |
| VILLAGE OF HOPE AMERICA INC | Dover | E92 Health Care | $3.6M | 4 |
| The Enoch Foundation | Wilmington | — | $3.5M | 0 |
| Barbara Barnard Smith Foundation | Wilmington | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $3.5M | 0 |
| DELMARVA TEEN CHALLENGE INC | Seaford | P28Z Human Services | $3.5M | 2 |
| HOCKESSIN FIRE COMPANY | Hockessin | — | $3.5M | 0 |
| BRANDYWINE HUNDRED FIRE COMPANY NO 1 | Wilmington | M24 Public Safety, Disaster Preparedness & Relief | $3.5M | 0 |
| Michael and Andrea Leven Family Foundation | Wilmington | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $3.5M | 0 |
| Stella Roy Foundation | Wilmington | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $3.5M | 0 |
| HOCKESSIN MONTESSORI SCHOOL | Hockessin | B21Z Education | $3.5M | 1 |
| OUR YOUTH INC | Wilmington | P30 Human Services | $3.5M | 0 |
