| MILLVILLE VOLUNTEER FIRE CO INC | Millville | M24 Public Safety, Disaster Preparedness & Relief | $4M | 0 |
| Dallas Morse Coors Foundation for the Performing Arts | Wilmington | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $4M | 0 |
| GREAT OAKS CHARTER SCHOOL - WILMINGTON INC | Wilmington | B25 Education | $4M | 1 |
| The Riedman Foundation | Wilmington | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $3.9M | 0 |
| Sylvan H Kline Family Foundation | Wilmington | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $3.9M | 0 |
| TRUST UA PHILIP F DUPONT FBO UNIVERSITY | Wilmington | B110 Education | $3.9M | 0 |
| TRUSTEES OF THE NEW CASTLE COMMON | New Castle | S220 Community Improvement & Capacity Building | $3.9M | 0 |
| WILMINGTON INSTITUTE FREE LIBRARY | Wilmington | — | $3.9M | 1 |
| HUMANE ANIMAL PARTNERS | Wilmington | D20 Animal-Related | $3.9M | 5 |
| Jean T and Heyward G Pelham Foundation | Wilmington | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $3.9M | 0 |
| The Prentice Foundation Inc | Wilmington | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $3.9M | 0 |
| Richard L and Diane M Block Foundation | Wilmington | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $3.8M | 6 |
| IGER BAY FOUNDATION | Wilmington | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $3.8M | 1 |
| PARTNERSHIP FOR THE DELAWARE ESTUARY INC | Wilmington | C30 Environment | $3.8M | 2 |
| MILLSBORO FIRE COMPANY INC | Millsboro | M24 Public Safety, Disaster Preparedness & Relief | $3.8M | 0 |
| Robinson Foundation | Wilmington | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $3.8M | 2 |
| LIBERATION VENTURES INC | Wilmington | R01 Civil Rights, Social Action & Advocacy | $3.7M | 0 |
| HUNTER CAPUZZI FAMILY FOUNDATION | Wilmington | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $3.7M | 0 |
| Joseph and Joan Cullman Conservation Foundation Inc | Wilmington | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $3.7M | 0 |
| Westmeath Foundation | Wilmington | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $3.7M | 2 |
| TRI-STATE COMMUNITY PARTNERS INC | Wilmington | — | $3.7M | 0 |
| The ZAC Foundation for Children's Safety | Wilmington | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $3.7M | 0 |
| Valley Fund Charitable Foundation | Wilmington | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $3.7M | 0 |
| CENTREVILLE LAYTON SCHOOL | Centreville | B280 Education | $3.7M | 3 |
| JOHN M PAZ FDN 12 23 10 JOHN M PAZ & BBHTCDE | Wilmington | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $3.7M | 1 |
| COLLEGIATE NETWORK INC | Wilmington | A33 Arts, Culture & Humanities | $3.7M | 1 |
| HARRISON HOUSE COMMUNITY PROGRAMS | New Castle | O99Z Youth Development | $3.6M | 2 |
| M & SA ZOLLO FOUNDATION | Wilmington | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $3.6M | 0 |
| Joseph and Joan Cullman Foundation for the Arts Inc | Wilmington | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $3.6M | 0 |
| DELAWARE HIV SERVICES INC | Wilmington | — | $3.6M | 1 |
| RUSSELL COLGATE FUND INC | Wilmington | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $3.6M | 0 |
| GIRL SCOUTS OF CHESAPEAKE BAY COUNCIL | Hockessin | O42Z Youth Development | $3.6M | 2 |
| VILLAGE OF HOPE AMERICA INC | Dover | E92 Health Care | $3.6M | 4 |
| The Enoch Foundation | Wilmington | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $3.5M | 0 |
| Barbara Barnard Smith Foundation | Wilmington | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $3.5M | 0 |
| DELMARVA TEEN CHALLENGE INC | Seaford | P28Z Human Services | $3.5M | 2 |
| HOCKESSIN FIRE COMPANY | Hockessin | — | $3.5M | 0 |
| BRANDYWINE HUNDRED FIRE COMPANY NO 1 | Wilmington | M24 Public Safety, Disaster Preparedness & Relief | $3.5M | 0 |
| Stella Roy Foundation | Wilmington | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $3.5M | 0 |
| HOCKESSIN MONTESSORI SCHOOL WILMINGTON MONTESSORI ASSOC INC | Hockessin | B21Z Education | $3.5M | 1 |
| OUR YOUTH INC | Wilmington | P30 Human Services | $3.5M | 0 |
| Marks Family Foundation | Wilmington | T21 Philanthropy, Voluntarism & Grantmaking Foundations | $3.5M | 1 |
| The Look and See Foundation | Wilmington | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $3.5M | 0 |
| Leder Family Foundation | Wilmington | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $3.5M | 0 |
| The Crimson Riverstone Foundation | Wilmington | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $3.5M | 0 |
| DELMAR FIRE DEPARTMENT INC | Delmar | M24 Public Safety, Disaster Preparedness & Relief | $3.5M | 0 |
| HILLTOP LUTHERAN NEIGHBORHOOD CENTER INC | Wilmington | P28Z Human Services | $3.5M | 1 |
| NANCY WOODSON SPIRE FOUNDATION INC | Greenville | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $3.5M | 0 |
| DELAWARE CENTER FOR JUSTICE | Wilmington | I20Z Crime & Legal-Related | $3.4M | 1 |
| Tapper Goodman Foundation | Wilmington | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $3.4M | 0 |
