| Good Samaritan Boys Ranch | Brighton | P72Z Human Services | $13.4M | 1 |
| BOONE COUNTY SENIOR CITIZENS SERVICES CORPORATION | Columbia | P81 Human Services | $13.3M | 2 |
| INDEPENDENCE CENTER | St Louis | — | $13.3M | 0 |
| SHIRLEY & BARNETT HELZBERG FOUNDATION | Kansas City | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $13.3M | 0 |
| METROPOLITAN ORGANIZATION COUNTERING SEXUAL ASSAULT | Kansas City | I73Z Crime & Legal-Related | $13.3M | 6 |
| TELECOMMUNICATIONS FACILITIES CORPORATION | St Louis | — | $13.3M | 0 |
| BLUE HILLS COUNTRY CLUB INC | Kansas City | — | $13.3M | 4 |
| SYLVIA G THOMPSON RESIDENCE CENTER | Sedalia | P750 Human Services | $13.2M | 2 |
| ST ANDREW'S AT FRANCIS PLACE | St Louis | — | $13.2M | 6 |
| BSDS INC BROOKSIDE CHARTER SCHOOL | Kansas City | B24 Education | $13.2M | 4 |
| CHOICES FOR PEOPLE CENTER FOR CITIZENS WITH DISABI | Rolla | P8XZ Human Services | $13.2M | 1 |
| Legal Aid of Western Missouri | Kansas City | I80Z Crime & Legal-Related | $13.1M | 5 |
| MIRIAM FOUNDATION | St Louis | B28Z Education | $13.1M | 5 |
| BOOTHEEL COUNSELING SERVICES | Sikeston | F600 Mental Health & Crisis Intervention | $13.1M | 6 |
| DOUGLASS COMMUNITY SERVICES INC | Hannibal | P200 Human Services | $13.1M | 1 |
| NEW HORIZONS COMMUNITY SUPPORT SERVICES INC | Jefferson City | — | $13M | 3 |
| MISSOURI FAMILY HEALTH COUNCIL INC | Jefferson City | E31Z Health Care | $13M | 5 |
| THE COMMUNITY FOUNDATION OF NORTHWEST MISSOURIINC | Saint Joseph | T30 Philanthropy, Voluntarism & Grantmaking Foundations | $13M | 2 |
| SECOND HARVEST COMMUNITY FOOD BANK | St Joseph | — | $12.9M | 1 |
| ST LOUIS SCOTT GALLAGHER FOUNDATION | Fenton | N64Z Recreation & Sports | $12.9M | 6 |
| MASONIC HOME OF MISSOURI | Columbia | P750 Human Services | $12.9M | 2 |
| TEAMSTERS LOCAL 682 HEALTH AND WELFARE TRUST FUND | Maryland Heights | — | $12.8M | 4 |
| PRIVATE EDUCATION EMPLOYERS' TRUST | St Louis | — | $12.8M | 0 |
| CARPENTERS JOINT TRAINING FUND OF ST LOUIS | St Louis | B30 Education | $12.8M | 0 |
| NOVA CENTER OF THE OZARKS INC | Springfield | P80Z Human Services | $12.8M | 1 |
| ELECTRO SAVINGS CREDIT UNION | St Louis | — | $12.7M | 7 |
| VIA CHRISTI VILLAGE MANHATTAN INC | St Louis | — | $12.7M | 10 |
| MARY QUEEN AND MOTHER ASSOCIATION | St Louis | P750 Human Services | $12.7M | 3 |
| West Vue Inc | West Plains | — | $12.7M | 1 |
| Amethyst Place Inc | Kansas City | F22 Mental Health & Crisis Intervention | $12.7M | 1 |
| NATIONAL ASSOCIATION OF ELECTRICAL DISTRIBUTORS INC | St Louis | — | $12.6M | 9 |
| THE WILLIAM R ORTHWEIN JR AND LAURA RAND ORTHWEIN FOUNDATION INC | St Louis | T12 Philanthropy, Voluntarism & Grantmaking Foundations | $12.6M | 1 |
| ST LOUIS DEVELOPMENT CORPORATION | St Louis | — | $12.6M | 6 |
| THE OPPORTUNITY TRUST D/B/A ZEST EDUCATION | St Louis | B19 Education | $12.6M | 8 |
| COMMUNITY LIVING INC | Saint Peters | P820 Human Services | $12.6M | 1 |
| GUADALUPE CENTERS INC | Kansas City | P33Z Human Services | $12.6M | 2 |
| ALEXIAN BROTHERS SHERBROOKE VILLAGE | St Louis | P750 Human Services | $12.5M | 7 |
| AMERICAN ROYAL ASSOCIATION INC | Kansas City | N520 Recreation & Sports | $12.5M | 6 |
| PARAQUAD INC | St Louis | — | $12.5M | 2 |
| MISSOURI SCHOOL BOARDS' ASSOCIATION | Columbia | — | $12.4M | 1 |
| CATHOLIC CHARITIES OF KANSAS CITY - ST JOSEPH INC | Kansas City | P20Z Human Services | $12.4M | 2 |
| NORTH CENTRAL MISSOURI MENTAL HEALTH CENTER | Trenton | F32Z Mental Health & Crisis Intervention | $12.3M | 6 |
| VILLAGE NORTH INC | Saint Louis | P75Z Human Services | $12.3M | 0 |
| CORTEX | St Louis | S20 Community Improvement & Capacity Building | $12.3M | 7 |
| Humphreys County Community Health Services Inc | St Louis | E20 Health Care | $12.3M | 11 |
| CHILDREN'S HOME SOCIETY OF MISSOURI | St Louis | P34Z Human Services | $12.3M | 6 |
| UNITED ASSOCIATION OF PLUMBERS LOCAL 8 HEALTH & WELFARE FUND | Kansas City | — | $12.3M | 1 |
| Burrell-Preferred Inc | Springfield | E60 Health Care | $12.2M | 8 |
| COMMUNITY SCHOOL ASSOCIATION | Saint Louis | — | $12.2M | 4 |
| VISITING NURSE ASSOCIATION OF SOUTHEAST MO | Kennett | E92 Health Care | $12.1M | 1 |
