| Northwestern Memorial HealthCare Group | Chicago | E22 Health Care | $10.1B | 52 |
| ADVOCATE HEALTH AND HOSPITALS CORP | Oak Brook | E210 Health Care | $6.9B | 31 |
| CENTRAL STATES SOUTHEAST & SOUTHWEST AREAS HEALTH & WELFARE FUND | Chicago | — | $5.5B | 15 |
| Feeding America | Chicago | K310 Food, Agriculture & Nutrition | $4.9B | 18 |
| University of Chicago | Chicago | — | $4.7B | 28 |
| Northwestern University | Evanston | N500 Recreation & Sports | $4.2B | 37 |
| OSF Healthcare System | Peoria | E220 Health Care | $3.9B | 50 |
| University of Chicago Medical Center | Chicago | E220 Health Care | $2.9B | 38 |
| RUSH University Medical Center | Chicago | E22 Health Care | $2.7B | 62 |
| The Chicago Community Trust | Chicago | T310 Philanthropy, Voluntarism & Grantmaking Foundations | $2.5B | 11 |
| Northwestern Memorial HealthCare | Chicago | E22 Health Care | $2.3B | 0 |
| Endeavor Health Clinical Operations | Arlington Heights | E220 Health Care | $2.2B | 36 |
| MODERN WOODMEN OF AMERICA | Rock Island | — | $2B | 28 |
| LOYOLA UNIVERSITY MEDICAL CENTER | Maywood | E220 Health Care | $1.6B | 17 |
| MEMORIAL HEALTH SYSTEM GROUP | Springfield | — | $1.6B | 39 |
| Ann & Robert H Lurie Children's Hospital of Chicago | Chicago | E24Z Health Care | $1.5B | 16 |
| THE CARLE FOUNDATION HOSPITAL | Urbana | E220 Health Care | $1.4B | 26 |
| UNITE HERE HEALTH | Aurora | — | $1.3B | 9 |
| ADVOCATE NORTH SIDE HEALTH NETWORK | Oak Brook | E220 Health Care | $1.2B | 29 |
| LINE CONSTRUCTION BENEFIT FUND | Lombard | — | $1.2B | 16 |
| Alliant Credit Union | Chicago | W61 Public & Societal Benefit | $1.2B | 21 |
| DELTA DENTAL OF ILLINOIS | Naperville | — | $1B | 30 |
| Loyola University of Chicago | Chicago | B430 Education | $992.7M | 29 |
| Edward Hospital | Arlington Heights | E220 Health Care | $908.3M | 30 |
| ACCENTURE UNITED STATES BENEFIT TRUST | Chicago | Y43 Mutual & Membership Benefit | $901.3M | 1 |
| JOHN D AND CATHERINE T MACARTHUR | Chicago | T20Z Philanthropy, Voluntarism & Grantmaking Foundations | $890.9M | 20 |
| The Big Ten Conference Inc | Rosemont | — | $879.9M | 30 |
| DEPAUL UNIVERSITY | Chicago | B430 Education | $848.4M | 35 |
| BLUE CROSS BLUE SHIELD ASSOCIATION | Chicago | E80 Health Care | $819.1M | 44 |
| SwedishAmerican Hospital | Rockford | E220 Health Care | $806.1M | 24 |
| MIDWEST OPERATING ENGINEERS WELFARE FUND | Countryside | — | $758.9M | 11 |
| Endeavor Health Medical Group | Arlington Heights | E110 Health Care | $730.7M | 35 |
| Fermi Research Alliance LLC | Batavia | U02 Science & Technology | $715.5M | 31 |
| ULSE INC | Evanston | W90 Public & Societal Benefit | $709.4M | 26 |
| Southern Illinois Hospital Services | Carbondale | E220 Health Care | $707.2M | 30 |
| BLESSING HOSPITAL | Quincy | E220 Health Care | $704.7M | 17 |
| Elmhurst Memorial Healthcare Group | Elmhurst | — | $640.9M | 38 |
| St John's Hospital of the Hospital Sisters of the Third Order of St Francis | Springfield | E220 Health Care | $639.5M | 11 |
| ABBVIE PATIENT ASSISTANCE FOUNDATION | North Chicago | — | $619.1M | 0 |
| Northwest Community Hospital | Arlington Heights | E220 Health Care | $616M | 18 |
| ADVOCATE CONDELL MEDICAL CENTER | Oak Brook | E22 Health Care | $592M | 30 |
| Silver Cross Hospital and Medical | New Lenox | E220 Health Care | $587.8M | 8 |
| The Carle Foundation | Urbana | E210 Health Care | $575.4M | 19 |
| SARAH BUSH LINCOLN HEALTH CENTER | Mattoon | E220 Health Care | $568.2M | 20 |
| ADVOCATE SHERMAN HOSPITAL | Oak Brook | E220 Health Care | $526.1M | 46 |
| Builders Initiative Foundation | Chicago | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $519.9M | 0 |
| Midwestern University | Downers Grove | B500 Education | $518.1M | 19 |
| MIDWEST FOOD BANK NFP | Normal | P99 Human Services | $506M | 5 |
| TRINITY MEDICAL CENTER | Rock Island | E220 Health Care | $477.9M | 18 |
| OSF Multi-Specialty Group | Peoria | E112 Health Care | $475.1M | 10 |
