| ALIANZA DE MUSEOS DE PUERTO RICO | San Juan | A90 Arts, Culture & Humanities | $526k | 2 |
| HOGAR DE AYUDA EL REFUGIO INC | Catano | F200 Mental Health & Crisis Intervention | $518k | 0 |
| FIDEICOMISO JOSE R ALVAREZ & GLORIA FIGUERAS | San Juan | X99 Religion-Related | $516k | 0 |
| FILANTROPIA PUERTO RICO INC | San Juan | T02 Philanthropy, Voluntarism & Grantmaking Foundations | $516k | 1 |
| EGIDA RYDER INC | Humacao | L22 Housing & Shelter | $515k | 0 |
| UNION DE CARPINTEROS DE PUERTO RICO | San Juan | Y24 Mutual & Membership Benefit | $506k | 5 |
| FUNDACION CREEMOS EN TI CORPORATION | Bayamon | F22 Mental Health & Crisis Intervention | $504k | 1 |
| FUNDACION PEDIATRICA DE DIABETES INC | San Juan | G80 Diseases, Disorders & Medical Disciplines | $500k | 1 |
| FUNDACION PARA EL FUTURO DE LA SALUD INC | San Juan | T50 Philanthropy, Voluntarism & Grantmaking Foundations | $500k | 1 |
| ASOCIACION ACIRC CORP | San Juan | A20 Arts, Culture & Humanities | $500k | 2 |
| LA CASA DEL LIBRO INC | San Juan | A50 Arts, Culture & Humanities | $498k | 1 |
| CENTRO DE DESARROLLO Y SERVICI ESPECIALIZADOS INC | Mayaguez | B28 Education | $496k | 1 |
| FUNDACION BIBLIOTECA RAFAEL HERNANDEZ COLON INC FUNDACION BIBLIOTECA RAFAEL HERNANDEZ COLON INC | Ponce | A72Z Arts, Culture & Humanities | $495k | 1 |
| LEE CONMIGO INC | Guaynabo | O50 Youth Development | $491k | 0 |
| MOVIMIENTO ANANSE INC | Carolina | R30 Civil Rights, Social Action & Advocacy | $488k | 0 |
| Gibaro De Puerto Rico Inc | San Juan | A23 Arts, Culture & Humanities | $488k | 2 |
| INITIATIVE FOR INDEPENDENT SCH IN PR INC | Aguadilla | B21 Education | $486k | 1 |
| VIEQUES HUMANE SOCIETY & ANIMAL RESCUE INC | Vieques | D200 Animal-Related | $480k | 0 |
| YOUTH FOR CHRIST PR INC | Aguadilla | O55 Youth Development | $478k | 0 |
| INSTITUTO DE PSICOTRAUMATOLOGIA DE PR INC | Bayamon | P62 Human Services | $477k | 2 |
| KILOMETRO 0 INC | San Juan | I20 Crime & Legal-Related | $476k | 0 |
| CENTRO DE SERVICIOS COMUNITARIOS VIDA PLENA INC | San Juan | P200 Human Services | $474k | 0 |
| FUNDACION MODESTO GOTAY PRO PERSONAS CON DISCAPACIDAD INTELECT | Trujillo Alto | — | $473k | 0 |
| ESPACIOS ABIERTOS PUERTO RICO INC | San Juan | W24 Public & Societal Benefit | $473k | 1 |
| HOGAR ELISABET JARDIN DEL EDEN CORP | Bayamon | E92 Health Care | $473k | 2 |
| HOGAR PAZ DE CRISTO INC | Coto Laurel | P81 Human Services | $472k | 0 |
| CAMARA DE COMERCIO DEL SUR DE PUERTO RICO INC | Ponce | S41 Community Improvement & Capacity Building | $471k | 1 |
| RAYITO DE ESPERANZA CORP | San Juan | P20 Human Services | $470k | 1 |
| CENTRO DE CUIDADO DIURNO MUNDO INFANTL INC | Mayaguez | P33 Human Services | $469k | 0 |
| Programa del Adolescente de Naranjito Inc | Naranjito | P80 Human Services | $468k | 0 |
| INDUSTRY UNIVERSITY RESEARCH CENTER INC | San Juan | S30 Community Improvement & Capacity Building | $467k | 1 |
| BROWNIE BLONDIE FOUNDATION INC | Caguas | D20 Animal-Related | $464k | 2 |
| CASA DORADA INC | Ponce | L22 Housing & Shelter | $463k | 0 |
| SEMBRANDO SENTIDO INC | San Juan | Q32 International, Foreign Affairs & National Security | $461k | 1 |
| TE AMO PR | San Juan | P60 Human Services | $458k | 0 |
| CENTRO ESPERANZA INC | Loiza | P30 Human Services | $458k | 1 |
| DEPARTAMENTO DE LA COMIDA DE PUERTO RICO INC | Caguas | P20 Human Services | $456k | 2 |
| PARCELERAS AFROCARIBENAS POR LA TRANSFORM BARRIAL | Saint Just | K02 Food, Agriculture & Nutrition | $451k | 1 |
| DE FRENTE AL ALZHEIMER INC | San Juan | P12 Human Services | $449k | 1 |
| SABANA GRANDE COMMUNITY AND ECONOMIC DEVELOPMENT | Sabana Grande | S20 Community Improvement & Capacity Building | $447k | 3 |
| University of Puerto Rico Foundation Inc | San Juan | B11 Education | $445k | 0 |
| RYDER VILLAGE INC | Humacao | P75 Human Services | $443k | 0 |
| MEMORIA DECOLONIAL INC | San Juan | B90 Education | $440k | 3 |
| CENTRO DE RENOVACION Y DESAROLLO HUMANO-ESPIRTUAL BUEN PASTOR | Caguas | F60 Mental Health & Crisis Intervention | $437k | 0 |
| RENACER SOCIAL CORP | Cidra | P46 Human Services | $436k | 1 |
| Estancia Dorada Corp | Caguas | P85 Human Services | $435k | 0 |
| UNIVERSITY OF PUERTO RICO LAW SCHOOL TRUST | San Juan | Q300 International, Foreign Affairs & National Security | $434k | 2 |
| HOGAR SANTISIMA TRINIDAD INC | Bayamon | F20 Mental Health & Crisis Intervention | $428k | 1 |
| HOGARES RAFAELA YBARRA | San Juan | O50 Youth Development | $427k | 1 |
| CORPORACION EL PUNTO EN LA MONTANA | San Juan | G81 Diseases, Disorders & Medical Disciplines | $422k | 1 |
