| MENNONITE GENERAL HOSPITAL INC | Cidra | E220 Health Care | $384.8M | 25 |
| HOSPITAL ESPAOL AUXILIO MUTUO DE PUERTO RICO INC | San Juan | E220 Health Care | $266M | 17 |
| INTER AMERICAN UNIVERSITY OF PUERTO RICO | San Juan | B430 Education | $241.2M | 19 |
| SISTEMA UNIVERSITARIO ANA G MENDEZ INCORPORADO | San Juan | B430 Education | $178.2M | 22 |
| MED CENTRO INC | Mercedita | — | $167.7M | 55 |
| HOSPITAL MENONITA CAGUAS INC | Cidra | E20 Health Care | $144.1M | 20 |
| Salud Integral de la Montana Inc | Naranjito | E320 Health Care | $126.1M | 10 |
| SOCIEDAD ESPAOLA DE AUXILIO MUTUO Y BENEFICENCIA DE PUERTO RICO | San Juan | E220 Health Care | $112.8M | 0 |
| NEOMED CENTER INC NEOMED CENTER INC | Gurabo | — | $88.2M | 9 |
| CORPORACION PARA LA PROMOCION DE PUERTO RICO COMO DESTINO INC | San Juan | W02 Public & Societal Benefit | $75.4M | 21 |
| PRESBYTERIAN COMMUNITY HOSPITAL INC | San Juan | — | $73.8M | 14 |
| HOSPITAL DAMAS INC | Ponce | — | $73.3M | 11 |
| SERVICIOS MDICOS UNIVERSITARIOS INC | Carolina | E20 Health Care | $69M | 11 |
| PONTIFICAL CATHOLIC UNIVERSITY OF PUERTO RICO | Ponce | B430 Education | $67.6M | 6 |
| HOSPITAL MENONITA HUMACAO INC | Cidra | E20 Health Care | $59.6M | 15 |
| UNIVERSIDAD POLITECNICA DE PUERTO RICO INC | San Juan | B430 Education | $52.3M | 3 |
| UNIVERSIDAD DEL SAGRADO CORAZON INC | San Juan | B42 Education | $51.5M | 26 |
| COOPERATIVA DE AHORRO Y CREDITO DE ARECIBO | Arecibo | — | $48.9M | 4 |
| EDP UNIVERSITY OF PUERTO RICO | San Juan | B40 Education | $47.5M | 2 |
| CENTRO DE SALUD DE LARES INC | Lares | E32Z Health Care | $46.1M | 15 |
| CARLOS ALBIZU UNIVERSITY | San Juan | B12 Education | $40.7M | 20 |
| CAMUY HEALTH SERVICES INC | Camuy | — | $39.9M | 6 |
| CENTRO DE SERVICIOS PRIMARIOS DE SALUD DE PATILLAS INC | Patillas | — | $37.6M | 25 |
| PUERTO RICO INDUSTRIES FOR THE BLIND | Mayaguez | J30 Employment | $36.9M | 1 |
| BOYS & GIRLS CLUBS OF PUERTO RICO INC | Carolina | — | $36.3M | 10 |
| PUERTO RICO SCIENCE TECHNOLOGY AND RESEARCH TRUST | San Juan | U05 Science & Technology | $36.3M | 4 |
| Prymed Medical Care Inc | Ciales | E20Z Health Care | $34.5M | 3 |
| CENTRO ARARAT INC | Ponce | E32 Health Care | $33.2M | 11 |
| ASOCIACION DE MAESTROS DE PUERTO RICO | San Juan | J40 Employment | $31.6M | 5 |
| HOSPITAL COMUNITARIO BUEN SAMARITANO INC | Aguadilla | E20 Health Care | $31M | 7 |
| UNIVERSIDAD CENTRAL DEL CARIBE | Bayamon | B500 Education | $30.7M | 2 |
| COOPERATIVA DE AHORRO Y CREDITO DE BARRANQUITAS | Barranquitas | — | $30.6M | 4 |
| COOPERATIVA DE AHORRO Y CREDITO ORIENTAL | Humacao | — | $29.8M | 4 |
| FUNDACION PARA EL DESAROLLO DEL HOGAR PROPIO INC | Caguas | — | $28.5M | 2 |
| HOSPITAL SAN CARLOS BORROMEO INC | Moca | — | $27.7M | 10 |
| LIGA PUERTORRIQUENA CONTRA EL CANCER | San Juan | E22 Health Care | $26.1M | 20 |
| COOPERATIVA DE AHORRO Y CREDITO DE CAMUY | Camuy | — | $24.9M | 4 |
| ALIANZA MUNICIPAL DE SERVICIOS | Caguas | — | $23.9M | 6 |
| COOPERATIVA DE AHORRO Y CREDITO DE MANATI INC | Manati | — | $23.9M | 17 |
| COOPERATIVA DE AHORRO Y CREDITO DE ISABELA | Isabela | — | $23.4M | 1 |
| PUERTO RICO LEGAL SERVICES INC | San Juan | — | $23.3M | 8 |
| COOPERATIVA DE CREDITO CABO ROJO | Cabo Rojo | W61 Public & Societal Benefit | $22.2M | 7 |
| Puerto Rico Conservation Trust Fund | San Juan | C300 Environment | $21.4M | 1 |
| COOPERATIVA DE AHORRO Y CREDITO SAN JOSE | Aibonito | — | $21.4M | 28 |
| SOCIEDAD PARA ASISTENCIA LEGAL DE PUERTO RICO INC | San Juan | I80 Crime & Legal-Related | $21.2M | 3 |
| PONCE MEDICAL SCHOOL FOUNDATION INC | Ponce | B500 Education | $19.1M | 0 |
| COOPERATIVA DE AHORRO Y CREDITO LA CANDELARIA | Manati | — | $18.7M | 2 |
| PUERTO RICO COMMUNITY NETWORK FOR CLINICAL SERVICES RESEARCH AND HEALTH AD | San Juan | H20Z Medical Research | $18.4M | 4 |
| COOPERATIVA AC LA SAGRADA FAMILIA | Corozal | W610 Public & Societal Benefit | $18.4M | 14 |
| PARA LA NATURALEZA INC | San Juan | C30 Environment | $18.3M | 9 |
