| CHARLESTON DAY SCHOOLINC | Charleston | B240 Education | $8.2M | 1 |
| CHEROKEE COUNTY CHARTER SCHOOL | Gaffney | B29 Education | $8.2M | 0 |
| Boys & Girls Clubs of the Midlands | Columbia | T50 Philanthropy, Voluntarism & Grantmaking Foundations | $8.1M | 1 |
| CAROLINA COMMUNITY CARE INC | Rock Hill | — | $8.1M | 4 |
| SC Thrive | Columbia | U19 Science & Technology | $8.1M | 4 |
| CLEMSON UNIVERSITY CONTINUING EDUCATION & CONFERENCE COMPLEX CORPORATION | Clemson | B110 Education | $8M | 6 |
| THE LANDER FOUNDATION | Greenwood | — | $7.9M | 0 |
| OCEANSIDE COLLEGIATE ACADEMY | Mount Pleasant | B29 Education | $7.9M | 1 |
| HOMES OF HOPE INC | Greenville | L25 Housing & Shelter | $7.8M | 1 |
| Winthrop University Foundation | Rock Hill | B43I Education | $7.7M | 2 |
| PRISMA HEALTH MIDLANDS FOUNDATION F/K/A PALMETTO HEALTH FOUNDATION | Columbia | E12 Health Care | $7.7M | 3 |
| Guardian Research Network Inc | Spartanburg | G30 Diseases, Disorders & Medical Disciplines | $7.7M | 5 |
| HABITAT FOR HUMANITY OF GREENVILLE COUNTY SC INC | Greenville | L20Z Housing & Shelter | $7.7M | 1 |
| CHESTERFIELD-MARLBORO COUNTIES ECONOMIC OPPORTUNITY COUNCIL INC | Cheraw | J22Z Employment | $7.7M | 0 |
| Tri-County Commission on Alcohol and Drug Abuse | Orangeburg | — | $7.7M | 3 |
| TRIDENT AREA AGENCY ON AGING | Charleston | P81Z Human Services | $7.6M | 1 |
| ST JAMES HEALTH AND WELLNESS INC | McClellanville | — | $7.6M | 9 |
| Foothills Community Foundation | Anderson | T310 Philanthropy, Voluntarism & Grantmaking Foundations | $7.6M | 1 |
| LOWCOUNTRY COMMUNITY ACTION AGENCY | Walterboro | S200 Community Improvement & Capacity Building | $7.5M | 0 |
| HORRY COUNTY COMMISSION ON ALCOHOL | Conway | — | $7.5M | 1 |
| MANNING EDUCATIONAL ASSOCIATION | Manning | — | $7.5M | 1 |
| PORTER-GAUD FOUNDATION | Charleston | — | $7.5M | 1 |
| ABLE SOUTH CAROLINA INC | Columbia | T010 Philanthropy, Voluntarism & Grantmaking Foundations | $7.5M | 1 |
| HOSPICE AND PALLIATIVE CARE OF THE PIEDMONT INC | Greenwood | — | $7.5M | 1 |
| PAWMETTO LIFELINE | Columbia | D200 Animal-Related | $7.5M | 1 |
| Greenville Housing Fund | Greenville | L20 Housing & Shelter | $7.5M | 3 |
| UPPER SAVANNAH COUNCIL OF GOVERNMENTS | Greenwood | W20B Public & Societal Benefit | $7.4M | 2 |
| WINDWOOD FARM HOME FOR CHILDREN INC | Awendaw | F33Z Mental Health & Crisis Intervention | $7.4M | 1 |
| COLUMBIA METROPOLITAN CONVENTION & VISITOR'S BUREAU | Columbia | — | $7.3M | 6 |
| SELF INSURANCE INSTITUTE OF AMERICA INC | Simpsonville | — | $7.3M | 0 |
| LOWCOUNTRY LEADERSHIP CHARTER SCHOOL | Hollywood | B29 Education | $7.3M | 1 |
| OPPORTUNITY SOUTH CAROLINA | Greenville | S30 Community Improvement & Capacity Building | $7.3M | 0 |
| YMCA OF COASTAL CAROLINA | Myrtle Beach | P27Z Human Services | $7.2M | 3 |
| SOUTH CAROLINA ACCELERATION ACADEMIES | North Charleston | — | $7.2M | 0 |
| GREER MIDDLE COLLEGE CHARTER HIGH SCHOOL | Taylors | B29 Education | $7.2M | 1 |
| South Carolina Hospital Association | Columbia | — | $7.2M | 7 |
| SPARTANBURG PREPARATORY SCHOOL | Spartanburg | B29 Education | $7.2M | 1 |
| EAST COOPER MONTESSORI CHARTER SCHOOL | Mount Pleasant | B29 Education | $7.2M | 2 |
| Prisma Health-Upstate Foundation | Greenville | T11 Philanthropy, Voluntarism & Grantmaking Foundations | $7.1M | 0 |
| TNKV FOUNDATION | Hilton Head Island | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $7.1M | 0 |
| CAROLINA VOYAGER CHARTER SCHOOL | Charleston | B99 Education | $7.1M | 1 |
| LEGION COLLEGIATE ACADEMY | Rock Hill | B29 Education | $7.1M | 0 |
| NEW MORNING | Columbia | T11 Philanthropy, Voluntarism & Grantmaking Foundations | $7.1M | 1 |
| LINCOLN TUBMAN FOUNDATION | Mt Pleasant | P62 Human Services | $7.1M | 1 |
| IVERSEN FAMILY FOUNDATION | Six Mile | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $7.1M | 0 |
| FRANCIS MARION UNIVERSITY DEVELOPMENT FOUNDATION | Florence | B19 Education | $7.1M | 2 |
| FLORENCE COUNTY COMMISSION ON ALCOHOL AND DRUG ABUSE | Florence | F20Z Mental Health & Crisis Intervention | $7.1M | 1 |
| CATAWBA REGIONAL COUNCIL OF GOVERNMENTS | Rock Hill | S310 Community Improvement & Capacity Building | $7M | 1 |
| MILLIKEN & COMPANY CHARITABLE FOUNDATION | Spartanburg | T21 Philanthropy, Voluntarism & Grantmaking Foundations | $7M | 0 |
| SOUTH CAROLINA FOR ONLINE EDUCATION INC | Summerville | B29 Education | $7M | 0 |
