| SOUTH DAKOTA VOICES FOR PEACE | Sioux Falls | — | $658k | 1 |
| BLACK HILLS CHILDREN'S RANCH INC | Rapid City | P51 Human Services | $658k | 3 |
| GREAT AFTER-SCHOOL PLACE | Brookings | B900 Education | $653k | 3 |
| WATERTOWN CONVENTION & VISITORS BUR | Watertown | S41 Community Improvement & Capacity Building | $650k | 1 |
| PRAIRIE HISTORICAL SOCIETY INC | Madison | A82Z Arts, Culture & Humanities | $649k | 2 |
| ARTS SOUTH DAKOTA INC | Sioux Falls | A20 Arts, Culture & Humanities | $648k | 0 |
| SPEARFISH ECONOMIC DEVELOPMENT CORP | Spearfish | — | $648k | 1 |
| SOUTH DAKOTA FFA FOUNDATION INC | Bath | — | $645k | 0 |
| NATIVE WOMENS SOCIETY OF THE GREAT PLAINS RECLAIMING OUR SACREDNESS | Eagle Butte | P62 Human Services | $644k | 1 |
| BROOKINGS AREA CHAMBER OF COMMERCE | Brookings | — | $641k | 1 |
| ACT 2 Inc | Aberdeen | A65 Arts, Culture & Humanities | $638k | 0 |
| Indoor Football League | Sioux Falls | N80 Recreation & Sports | $635k | 1 |
| CHILDREN'S HOUSE MONTESSORI | Rapid City | B20 Education | $633k | 2 |
| ENGELS FAMILY FOUNDATION | Watertown | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $631k | 0 |
| VC MEDICAL ENDOWMENT TRUST | Sioux Falls | T90 Philanthropy, Voluntarism & Grantmaking Foundations | $629k | 0 |
| SALEM MENNONITE HOME FOR THE AGED | Freeman | P75Z Human Services | $626k | 1 |
| Emilys Hope | Sioux Falls | P80 Human Services | $624k | 1 |
| WHETSTONE CREEK GOLF COURSE | Milbank | N6A Recreation & Sports | $621k | 0 |
| SOUTH DAKOTA ASSOCIATION OF COUNTY COMMISSIONERS | Pierre | — | $612k | 1 |
| SOUTH DAKOTA NEWS WATCH | Brookings | A33 Arts, Culture & Humanities | $611k | 1 |
| FORK REAL COMMUNITY CAFE INC | Rapid City | K30 Food, Agriculture & Nutrition | $610k | 1 |
| WHISPERING PINES VOL FIRE DEPT | Rapid City | — | $604k | 0 |
| HURON AREA WELLNESS AND RECREATION | Huron | N30 Recreation & Sports | $604k | 1 |
| BRANDON VALLEY BOOSTER CLUB INC | Brandon | B11 Education | $603k | 0 |
| PINE RIDGE GIRLS SCHOOL INC | Porcupine | B20 Education | $602k | 1 |
| BROOKINGS CONVENTION & VISITORS BUREAU | Brookings | Y03 Mutual & Membership Benefit | $600k | 0 |
| ALLY DAKOTA DEVELOPMENT INC | Rapid City | — | $600k | 0 |
| THE MULTIFAMILY IMPACT COUNCIL | Sioux Falls | L03 Housing & Shelter | $592k | 0 |
| VETERANS OF FOREIGN WARS POST 3507 | Britton | — | $591k | 0 |
| FIRST DISTRICT DEVELOPMENT COMPANY | Watertown | S43Z Community Improvement & Capacity Building | $591k | 0 |
| CAROL CLARKSON EKLUND FOUNDATION | Belle Fourche | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $588k | 1 |
| ALCESTER INDUSTRIAL PARK INC | Alcester | — | $588k | 0 |
| KEYSTONE AMBULANCE SERVICE INC | Keystone | E62 Health Care | $586k | 0 |
| FATTY ACID RESEARCH INSTITUTE | Sioux Falls | — | $586k | 1 |
| BROOKINGS FUTBOL CLUB | Brookings | N64 Recreation & Sports | $585k | 0 |
| Brandon Volunteer Fire Department | Brandon | M24 Public Safety, Disaster Preparedness & Relief | $583k | 5 |
| BATTLE MOUNTAIN HUMANE SOCIETY | Hermosa | D20 Animal-Related | $581k | 2 |
| NORTHERN PRAIRIES LAND TRUST | Sioux Falls | C27 Environment | $581k | 1 |
| MOBRIDGE COUNTRY CLUB | Mobridge | — | $580k | 1 |
| RUTH A AND RAYMOND A REISTER CHARITABLE TRUST | Sioux Falls | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $579k | 3 |
| LAKE REGION GOLF CLUB | Arlington | — | $574k | 0 |
| SOUTH DAKOTA AMATEUR HOCKEY | Watertown | O50 Youth Development | $574k | 1 |
| VERENDRYE MUSEUM INC | Fort Pierre | — | $571k | 0 |
| BOYS & GIRLS CLUB OF THE MISSOURI | Wagner | O23 Youth Development | $571k | 1 |
| BASEBALL PARENTS INC | Rapid City | W30Z Public & Societal Benefit | $568k | 0 |
| SOUTH DAKOTA INSURANCE GUARANTY | Sioux Falls | — | $568k | 0 |
| WALTER AND VIRGINIA HAGER | Mobridge | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $563k | 0 |
| SCHOOL ADMINISTRATORS OF SOUTH | Pierre | — | $561k | 1 |
| SHIFT GARAGE | Sioux Falls | P50 Human Services | $556k | 1 |
| Stanley Post 20 of the American Legion | Fort Pierre | W30 Public & Societal Benefit | $554k | 0 |
