| WAYNE COUNTY SCHOOL FOUNDATION | Waynesboro | B242 Education | $4.7M | 0 |
| THE GERTRUDE C FORD FOUNDATION INC | Ridgeland | — | $4.7M | 3 |
| MISSISSIPPI VOTES | Jackson | R40 Civil Rights, Social Action & Advocacy | $4.6M | 3 |
| SOUTHERN CHRISTIAN SERVICES FOR CHILDREN | Jackson | P20 Human Services | $4.6M | 2 |
| STEWPOT COMMUNITY SERVICES INC | Jackson | — | $4.6M | 1 |
| GULF OF MEXICO ALLIANCE | Ocean Springs | C60 Environment | $4.5M | 3 |
| CHILDRENS ADVOCACY CENTERS OF | Jackson | P01 Human Services | $4.5M | 1 |
| DELTA MEDICAL FOUNDATION | Marks | E32 Health Care | $4.5M | 3 |
| BLACK BAYOU WATER ASSOCIATION INC | Leland | — | $4.5M | 0 |
| TUPELO COUNTRY CLUB | Belden | — | $4.5M | 0 |
| MISSISSIPPI CONSORTIUM FOR INTERNATIONAL | Jackson | Q300 International, Foreign Affairs & National Security | $4.4M | 2 |
| COPIAH EDUCATIONAL FOUNDATION INC | Gallman | — | $4.4M | 1 |
| UNITED METHODIST SENIOR SERVICES OF | Tupelo | E91 Health Care | $4.4M | 6 |
| MID-STATE OPPORTUNITY INC | Charleston | L81Z Housing & Shelter | $4.3M | 2 |
| CENTRAL WATER ASSOCIATION INC | Philadelphia | — | $4.3M | 5 |
| ADAMS COUNTY CHRISTIAN SCHOOL | Natchez | B20 Education | $4.3M | 0 |
| National Association of Emergency | Ridgeland | — | $4.3M | 5 |
| INTERNATIONAL OUTREACH MINISTRIES | McComb | X20 Religion-Related | $4.3M | 2 |
| MISSISSIPPI POWER FOUNDATION INC | Gulfport | T20Z Philanthropy, Voluntarism & Grantmaking Foundations | $4.3M | 0 |
| TUPELO CHILDREN'S MANSION INC | Tupelo | — | $4.2M | 4 |
| Piney Woods School | Piney Woods | B25 Education | $4.2M | 0 |
| Central Mississippi Inc | Winona | P200 Human Services | $4.2M | 3 |
| HARBOR HOUSE OF JACKSON INC | Jackson | F34Z Mental Health & Crisis Intervention | $4.1M | 1 |
| MS Delta Academies dba Leflore Legacy Ac | Greenwood | B29 Education | $4.1M | 1 |
| Claiborne County Family Health Center Inc | Port Gibson | E32Z Health Care | $4.1M | 9 |
| MISSISSIPPI GULF COAST YOUNG MEN'S | Ocean Springs | P27Z Human Services | $4.1M | 1 |
| North Mississippi Emergency Services | Tupelo | E20 Health Care | $4.1M | 3 |
| CATHOLIC SOCIAL AND COMMUNITY SERVICES | Biloxi | P200 Human Services | $4.1M | 1 |
| MISSISSIPPI CENTER FOR JUSTICE | Jackson | I80 Crime & Legal-Related | $4.1M | 4 |
| MISSISSIPPI MANUFACTURERS | Jackson | — | $4.1M | 4 |
| INDIANOLA EDUCATIONAL FOUNDATION IN | Indianola | B24Z Education | $4.1M | 0 |
| THE STEVE AND MELODY GOLDING FOUNDATION | Vicksburg | — | $4.1M | 0 |
| MAGNOLIA SPEECH SCHOOL | Madison | E56Z Health Care | $4M | 0 |
| HORN LAKE WATER ASSOCIATION INC | Horn Lake | — | $4M | 1 |
| THE REDEEMERS SCHOOL | Jackson | B20 Education | $4M | 1 |
| AJFC COMMUNITY ACTION AGENCY | Natchez | P20Z Human Services | $4M | 0 |
| Outreach Health Services Inc | Shubuta | E320 Health Care | $4M | 5 |
| DELTA WILDLIFE INC | Stoneville | C300 Environment | $4M | 0 |
| North MS Rural Legal Services Inc | Oxford | I80Z Crime & Legal-Related | $3.9M | 4 |
| NORTH LAMAR WATER ASSOCIATION | Hattiesburg | — | $3.9M | 0 |
| ANNANDALE INC | Madison | — | $3.9M | 0 |
| BUT GOD MINISTRIES | Madison | Q32 International, Foreign Affairs & National Security | $3.9M | 2 |
| MARSHALL COUNTY WATER ASSOCIATION | Byhalia | — | $3.8M | 0 |
| NATIONAL TILE CONTRACTORS ASSN INC | Jackson | — | $3.8M | 2 |
| GULF COAST CENTER FOR NONVIOLENCE | Biloxi | — | $3.8M | 1 |
| PEOPLES ADVOCACY INSTITUTE | Jackson | A01 Arts, Culture & Humanities | $3.8M | 0 |
| NORTHSTAR INTERNATIONAL ACADEMYINC | Southaven | B28 Education | $3.8M | 4 |
| YOUNG MENS CHRISTIAN ASSOCIATION | Flowood | P27 Human Services | $3.7M | 3 |
| OPERATION SHOESTRING INC | Jackson | P200 Human Services | $3.7M | 1 |
| THE ALLIANCE | Corinth | — | $3.7M | 2 |
