| AMBITION PREPARATORY CHARTER SCHOOL | Jackson | B29 Education | $6.8M | 2 |
| NORTH CENTRAL PLANNING AND DEVELOPM | Winona | P200 Human Services | $6.8M | 3 |
| DELTA STATE UNIVERSITY FOUNDATION | Cleveland | — | $6.6M | 0 |
| ERGON FOUNDATION INC | Jackson | — | $6.5M | 0 |
| UNITED METHODIST MINISTRY WITH | Jackson | P30 Human Services | $6.4M | 2 |
| BREVARD FAMILY FOUNDATION | Tupelo | T22Z Philanthropy, Voluntarism & Grantmaking Foundations | $6.4M | 0 |
| RUSH CARE INC | Meridian | E24 Health Care | $6.3M | 7 |
| MAGNOLIA HEIGHTS SCHOOL INC | Senatobia | B242 Education | $6.3M | 1 |
| THE JOSEPH C BANCROFT CHARITABLE AND | McComb | T900 Philanthropy, Voluntarism & Grantmaking Foundations | $6.2M | 4 |
| DEEP SOUTH TODAY | Ridgeland | A30 Arts, Culture & Humanities | $6.1M | 7 |
| CADENCE BANK FOUNDATION | Tupelo | T90 Philanthropy, Voluntarism & Grantmaking Foundations | $6.1M | 1 |
| BROOKHAVEN ACADEMY EDUCATIONAL | Brookhaven | B242 Education | $6.1M | 0 |
| SUNFLOWER-HUMPHREYS CTYS PROG INC | Indianola | S200 Community Improvement & Capacity Building | $6M | 1 |
| SHAW EDUCATIONAL FOUNDATION INC | Cleveland | B20 Education | $6M | 0 |
| NETWORK OF INTERNATIONAL CHRISTIAN | Southaven | X20Z Religion-Related | $5.9M | 4 |
| WILLOWOOD DEVELOPMENTAL CENTER INC | Jackson | — | $5.9M | 1 |
| REGENTS SCHOOL OF OXFORD INC | Oxford | B24 Education | $5.9M | 3 |
| Prairie Opportunity Inc | Starkville | S200 Community Improvement & Capacity Building | $5.8M | 2 |
| TUPELO CHRISTIAN PREPARATORY SCHOOL | Belden | B24Z Education | $5.8M | 1 |
| PALMER HOME FOR CHILDREN | Lake Cormorant | P730 Human Services | $5.8M | 4 |
| RIVER HILLS CLUB OF JACKSON | Jackson | — | $5.7M | 1 |
| THE RILEY FOUNDATION | Meridian | Z99Z Unknown | $5.6M | 12 |
| SPRINGBOARD TO OPPORTUNITIES | Jackson | P20 Human Services | $5.6M | 1 |
| PARK PLACE CHRISTIAN ACADEMY INC | Pearl | B24 Education | $5.6M | 0 |
| PINEBELT FOUNDATION | Hattiesburg | T31 Philanthropy, Voluntarism & Grantmaking Foundations | $5.6M | 0 |
| PROGRESS COMMUNITY WATER ASSOCIATION | Purvis | — | $5.6M | 0 |
| Mississippi Center For Legal Services Corporation | Hattiesburg | — | $5.6M | 3 |
| CENTRAL MISSISSIPPI HEALTH SERVICES | Jackson | — | $5.5M | 8 |
| ANDERSON PHYSICIAN ALLIANCE INC | Meridian | E31 Health Care | $5.5M | 11 |
| GRACE HOUSE INC | Jackson | L99Z Housing & Shelter | $5.4M | 1 |
| ALCORN STATE UNIVERSITY FOUNDATION INC | Lorman | B43I Education | $5.4M | 0 |
| OAKWOOD FOUNDATION CHARITABLE TRUST | Tupelo | T22Z Philanthropy, Voluntarism & Grantmaking Foundations | $5.4M | 0 |
| EAST LOWNDES WATER ASSOCIATION | Columbus | — | $5.4M | 5 |
| RENAISSANCE COMMUNITY LOAN FUND | Gulfport | M20 Public Safety, Disaster Preparedness & Relief | $5.4M | 5 |
| MISSISSIPPI STATE UNIVERSITY | Mississippi State | — | $5.4M | 0 |
| Lift Inc | Tupelo | — | $5.3M | 2 |
| COMMUNITY DEVELOPMENT FOUNDATION | Tupelo | — | $5.3M | 0 |
| ALUMNI ASSOCIATION OF THE UNIVERSITY OF | Oxford | B84Z Education | $5.2M | 1 |
| WASHINGTON COUNTY DAY SCHOOL | Greenviile | B20 Education | $5.2M | 3 |
| MISSISSIPPI HIGH SCHOOL ACTIVITIES ASSOCIATION INC | Clinton | L41D Housing & Shelter | $5.2M | 3 |
| HOPE VILLAGE FOR CHILDREN INC | Meridian | P43 Human Services | $5.2M | 0 |
| THE BOYS AND GIRLS CLUBS OF THE GULF | Gulfport | — | $5.1M | 1 |
| MISSISSIPPI CHILDREN'S HOME SERVICES | Jackson | P193 Human Services | $5.1M | 11 |
| COLUMBUS EDUCATIONAL FOUNDATION INC | Columbus | B24Z Education | $5.1M | 1 |
| FIVE COUNTY CHILD DEVELOPMENT INC | Prentiss | B21 Education | $5.1M | 0 |
| MISSISSIPPI 811 INC | Pearl | — | $5M | 1 |
| WARREN COUNTY ASSOCIATION FOR RETAR | Vicksburg | P82Z Human Services | $5M | 0 |
| Mississippi United to End Homelessness | Jackson | P85 Human Services | $4.9M | 2 |
| MERCY HOUSE ADULT & TEEN CHALLENGE | Jackson | F22 Mental Health & Crisis Intervention | $4.9M | 2 |
| MISSISSIPPI CHILDREN'S MUSEUM | Jackson | A52 Arts, Culture & Humanities | $4.8M | 2 |
