| SOUTH CAROLINA MEDICAL ASSOCIATION | Columbia | Y20Z Mutual & Membership Benefit | $3.1M | 12 |
| ALDERSGATE SPECIAL NEEDS MINISTRY | Ballentine | — | $3.1M | 1 |
| LAURENS EDUCATION ASSISTANCE FOR | Laurens | B11 Education | $3.1M | 0 |
| TRIDENT TECHNICAL COLLEGE FOUNDATION INC | Charleston | B11 Education | $3.1M | 1 |
| TYGER RIVER FOUNDATION | Spartanburg | C32 Environment | $3.1M | 0 |
| Plumbers & Pipefitters Local 421 | North Charleston | — | $3.1M | 4 |
| TRIDENT ACADEMY INC | Mt Pleasant | B28Z Education | $3.1M | 1 |
| THE ANMED HEALTH FOUNDATION | Anderson | E11 Health Care | $3.1M | 5 |
| COASTAL MONTESSORI CHARTER SCHOOL | Pawleys Island | B29 Education | $3.1M | 1 |
| Historic Columbia Foundation | Columbia | A82I Arts, Culture & Humanities | $3M | 3 |
| COASTAL HIGH SCHOOL | Myrtle Beach | B29 Education | $3M | 0 |
| COLLETON PREPARATORY ACADEMY INC | Walterboro | B24Z Education | $3M | 0 |
| PALMETTO ACADEMY FOR LEARNING | Conway | B29 Education | $3M | 1 |
| PRESBYTERIAN COLLEGE REAL ESTATE FOUNDATION | Clinton | B42I Education | $3M | 2 |
| PEE DEE MATH SCIENCE & TECHNOLOGY | Bishopville | B29 Education | $3M | 1 |
| THE SOUTH CAROLINA HISTORICAL SOCIETY | Charleston | A82Z Arts, Culture & Humanities | $3M | 3 |
| UPSTATE SC ALLIANCE INC | Greenville | S30 Community Improvement & Capacity Building | $3M | 1 |
| CHARLESTON JUNIOR GOLF FOUNDATION | Mount Pleasant | N6A Recreation & Sports | $3M | 1 |
| DISABILITY RIGHTS SOUTH | Columbia | R23Z Civil Rights, Social Action & Advocacy | $3M | 3 |
| CHILD ABUSE PREVENTION ASSOCIATION | Beaufort | I72Z Crime & Legal-Related | $3M | 1 |
| PALMETTO PROJECT INC | North Charleston | — | $2.9M | 2 |
| THE REINHARDT FAMILY FOUNDATION TRUST | Sullivans Island | — | $2.9M | 0 |
| CAROLINAS CREDIT UNION LEAGUE | Columbia | — | $2.9M | 6 |
| MIDDLETON PLACE FOUNDATION | Charleston | A540 Arts, Culture & Humanities | $2.9M | 2 |
| MOTHER EMANUEL MEMORIAL FOUNDATION | Charleston | R20 Civil Rights, Social Action & Advocacy | $2.9M | 1 |
| Boys and Girls Clubs of the Crescent | Columbia | — | $2.9M | 1 |
| HARBISON COMMUNITY ASSOCIATION INC | Columbia | — | $2.9M | 0 |
| BIBLE STUDY TIME INC | Spartanburg | — | $2.9M | 1 |
| Habitat for Humanity of York County Inc | Rock Hill | — | $2.9M | 1 |
| PEE DEE ACADEMY | Mullins | — | $2.9M | 0 |
| HILTON HEAD ISLAND DEEP WELL | Hilton Head Island | C22Z Environment | $2.9M | 1 |
| Rock Hill Country Club | Rock Hill | — | $2.9M | 0 |
| EASTERN CAROLINA COMMUNITY FOUNDATION | Florence | T31 Philanthropy, Voluntarism & Grantmaking Foundations | $2.9M | 1 |
| HARVESTERS INTERNATIONAL MINISTRIES | Hilton Head | X21 Religion-Related | $2.8M | 2 |
| GREENWOOD CHRISTIAN SCHOOL INC | Greenwood | — | $2.8M | 1 |
| SC CHAMBER OF COMMERCE | Columbia | — | $2.8M | 4 |
| PEE DEE HEALTHY START INC | Florence | E42 Health Care | $2.8M | 1 |
| THE PRESERVATION SOCIETY OF | Charleston | — | $2.8M | 2 |
| CLEMSON ALUMNI ASSOCIATION | Clemson | B12 Education | $2.8M | 3 |
| CHILDREN'S CANCER PARTNERS OF THE | Spartanburg | O50 Youth Development | $2.8M | 3 |
| SOUTH CAROLINA EDUCATION ASSOCIATION | West Columbia | — | $2.8M | 4 |
| EPISCOPAL HOUSING CORPORATION | Columbia | — | $2.8M | 0 |
| POPLAR SPRINGS FIRE SERVICE AREA | Moore | — | $2.8M | 1 |
| BELLE W BARUCH FOUNDATION | Georgetown | — | $2.8M | 1 |
| HORRY-GEORGETOWN TECHNICAL COLLEGE FOUNDATION INC | Conway | B110 Education | $2.8M | 0 |
| FALL FOR GREENVILLE INC | Greenville | N52Z Recreation & Sports | $2.8M | 0 |
| LEE ACADEMY OF BISHOPVILLE INC | Bishopville | — | $2.8M | 0 |
| ONE ELEUTHERA FOUNDATION | Clemson | O12 Youth Development | $2.8M | 1 |
| UNITED WAY OF THE LOWCOUNTRY | Beaufort | — | $2.8M | 1 |
| Midnight Call Inc | Lexington | — | $2.8M | 4 |
