| THE PALMETTO CLUB OF COLUMBIA | Columbia | — | $3.4M | 0 |
| COASTAL COMMUNITY DEVELOPMENT CORPORATION | Hilton Head Island | S20 Community Improvement & Capacity Building | $3.4M | 0 |
| SC AUTOMOBILE DEALERS ASSOCIATION | Columbia | — | $3.4M | 1 |
| CLIMB Fund | Charleston | S31 Community Improvement & Capacity Building | $3.4M | 1 |
| SOUTH CAROLINA BANKERS ASSOCIATION | Columbia | — | $3.4M | 3 |
| SOS HEALTH CARE INC | Myrtle Beach | — | $3.4M | 1 |
| INVESTSC INC | Columbia | S30 Community Improvement & Capacity Building | $3.4M | 1 |
| MEHER SPIRITUAL CENTER INC | Myrtle Beach | — | $3.4M | 1 |
| AIKEN AREA COUNCIL ON AGING INC | Aiken | P81Z Human Services | $3.4M | 0 |
| ELLISON S AND NOEL P MCKISSICK FOUNDATION | Greenville | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $3.4M | 0 |
| ANDERSON INTERFAITH MINISTRIES | Anderson | P600 Human Services | $3.3M | 1 |
| ATLANTIC COLLEGIATE ACADEMY | Conway | B29 Education | $3.3M | 0 |
| SPRING VALLEY COUNTRY CLUB | Columbia | — | $3.3M | 0 |
| THE ACADEMY OF ARTS | Taylors | — | $3.3M | 3 |
| CENTRAL SC HABITAT FOR HUMANITY | Columbia | — | $3.3M | 2 |
| Palmetto Promise Institute | Columbia | E057 Health Care | $3.3M | 2 |
| COASTAL MONTESSORI CHARTER SCHOOL | Pawleys Island | B29 Education | $3.3M | 1 |
| THE MARTHA AND JOHN M RIVERS PERFORMANCE HALL FOUNDATION | Charleston | A12 Arts, Culture & Humanities | $3.3M | 3 |
| Cameneti Ministries Inc | Taylors | X20Z Religion-Related | $3.3M | 2 |
| CROWN LEADERSHIP ACADEMY INC | Mount Pleasant | B25 Education | $3.3M | 2 |
| SOUTH CAROLINA RURAL WATER ASSOCIATION | Columbia | C32 Environment | $3.3M | 1 |
| DRAYTON HALL PRESERVATION TRUST | Charleston | P20 Human Services | $3.3M | 1 |
| BOYS AND GIRLS CLUB OF THE PEE DEE AREA INC | Florence | O21Z Youth Development | $3.3M | 1 |
| GREER RELIEF AND RESOURCES AGENCY INC | Greer | P40Z Human Services | $3.3M | 0 |
| SUMTER COUNTY COMMISSION ON ALCOHOL AND DRUG ABUSE | Sumter | F20Z Mental Health & Crisis Intervention | $3.3M | 1 |
| NEWBERRY OPERA HOUSE FOUNDATION INC | Newberry | A6A0 Arts, Culture & Humanities | $3.3M | 2 |
| UNITED HOUSING ASSOCIATES INC | Columbia | E910 Health Care | $3.3M | 0 |
| CASSELS FAMILY FOUNDATION | Lexington | T22Z Philanthropy, Voluntarism & Grantmaking Foundations | $3.3M | 0 |
| GIRL SCOUTS OF EASTERN SOUTH CAROLINA | North Charleston | O42 Youth Development | $3.3M | 1 |
| TAYLORS FREE MEDICAL CLINIC INC | Taylors | E32 Health Care | $3.3M | 1 |
| ST JOHN'S CHRISTIAN ACADEMY | Moncks Corner | B20 Education | $3.2M | 0 |
| HERMAN L ANDERSON INC | Conway | L22 Housing & Shelter | $3.2M | 0 |
| BELTON PREPARATORY ACADEMY INC | Belton | B29 Education | $3.2M | 0 |
| Greenville Classical Academy | Greenville | B24 Education | $3.2M | 1 |
| UPSTATE SC ALLIANCE INC | Greenville | S30 Community Improvement & Capacity Building | $3.2M | 1 |
| FACT FORWARD | Columbia | B99Z Education | $3.2M | 2 |
| SOUTH CAROLINA STATE UNIVERSITY REAL ESTATE FOUNDATION | Orangeburg | B190 Education | $3.2M | 3 |
| GLOBAL WATER CENTER | North Charleston | Q30 International, Foreign Affairs & National Security | $3.2M | 2 |
| PENDLETON PLACE INC | Greenville | P700 Human Services | $3.2M | 1 |
| HILTON HEAD ISLAND DEEP WELL PROJECT INC | Hilton Head Island | C22Z Environment | $3.2M | 1 |
| SOUTH CAROLINA MEDICAL ASSOCIATION | Columbia | Y20Z Mutual & Membership Benefit | $3.2M | 11 |
| SOUTH ATLANTIC CONFERENCE | Rock Hill | N70Z Recreation & Sports | $3.2M | 1 |
| CHAPIN WE CARE CENTER | Chapin | X21 Religion-Related | $3.2M | 1 |
| COASTAL HIGH SCHOOL | Myrtle Beach | B29 Education | $3.2M | 1 |
| Rock Hill Country Club | Rock Hill | — | $3.1M | 0 |
| HARBISON COMMUNITY ASSOCIATION INC | Columbia | — | $3.1M | 0 |
| CHAPMAN CULTURAL CENTER INC | Spartanburg | A260 Arts, Culture & Humanities | $3.1M | 1 |
| MILL VILLAGE MINISTRIES | Greenville | P20 Human Services | $3.1M | 1 |
| FLORENCE CRITTENTON PROGRAMS OF SOUTH CAROLINA INC | Charleston | P450 Human Services | $3.1M | 1 |
| ALDERSGATE SPECIAL NEEDS MINISTRY | Ballentine | — | $3.1M | 1 |
