| HILTON HEAD HUMANE ASSOCIATION | Hilton Head Island | D200 Animal-Related | $3.5M | 1 |
| LAKES AND BRIDGES CHARTER SCHOOL INC | Easley | B29 Education | $3.5M | 0 |
| THE UNIVERSITY CENTER OF GREENVILLE | Greenville | B82 Education | $3.5M | 2 |
| CHESTER FACILITIES CORPORATION | Chester | S99 Community Improvement & Capacity Building | $3.5M | 0 |
| ADDLESTONE HEBREW ACADEMY | Charleston | B24 Education | $3.5M | 1 |
| MARCO RURAL WATER CO INC | Marion | — | $3.5M | 10 |
| YORK COUNTY COUNCIL ON AGING INC | Rock Hill | P81Z Human Services | $3.5M | 1 |
| THE ACADEMY FOR TEACHING & LEARNING | Chester | B29 Education | $3.5M | 2 |
| SOUTH CAROLINA ACCELERATION ACADEMIES | North Charleston | — | $3.5M | 0 |
| Project MedSend | Fort Mill | B82 Education | $3.4M | 3 |
| YOUTH LEADERSHIP ACADEMY | Pickens | B29 Education | $3.4M | 0 |
| PAYMENTSFIRST INC | Columbia | — | $3.4M | 5 |
| GREENVILLE SYMPHONY ASSOCIATION | Greenville | A690 Arts, Culture & Humanities | $3.4M | 1 |
| CHILDREN'S ATTENTION HOME INC | Rock Hill | — | $3.4M | 2 |
| ECONOMIC DEVELOPMENT PARTNERSHIP | Aiken | — | $3.4M | 1 |
| THE ERNEST E KENNEDY CENTER INC | Moncks Corner | F50Z Mental Health & Crisis Intervention | $3.4M | 1 |
| SC AUTOMOBILE DEALERS ASSOCIATION | Columbia | — | $3.4M | 1 |
| JUMPSTART SOUTH CAROLINA | Spartanburg | I40 Crime & Legal-Related | $3.4M | 1 |
| SOUTH CAROLINA BANKERS ASSOCIATION | Columbia | — | $3.4M | 3 |
| SOS HEALTH CARE INC | Myrtle Beach | — | $3.4M | 1 |
| INVESTSC INC | Columbia | S30 Community Improvement & Capacity Building | $3.4M | 1 |
| MEHER SPIRITUAL CENTER INC | Myrtle Beach | — | $3.4M | 1 |
| AIKEN AREA COUNCIL ON AGING INC | Aiken | P81Z Human Services | $3.4M | 0 |
| ELLISON S AND NOEL P MCKISSICK | Greenville | — | $3.4M | 0 |
| ANDERSON INTERFAITH MINISTRIES | Anderson | P600 Human Services | $3.3M | 1 |
| ATLANTIC COLLEGIATE ACADEMY | Conway | B29 Education | $3.3M | 0 |
| SPRING VALLEY COUNTRY CLUB | Columbia | — | $3.3M | 0 |
| THE ACADEMY OF ARTS | Taylors | — | $3.3M | 3 |
| CHILDREN'S MUSEUM OF THE LOWCOUNTRY | Charleston | A520 Arts, Culture & Humanities | $3.3M | 2 |
| CENTRAL SC HABITAT FOR HUMANITY | Columbia | — | $3.3M | 2 |
| SOUTH CAROLINA RURAL WATER | Columbia | C32 Environment | $3.3M | 1 |
| SOUTH CAROLINA INFANT MENTAL HEALTH ASSO | Charleston | F03 Mental Health & Crisis Intervention | $3.3M | 0 |
| DRAYTON HALL PRESERVATION TRUST | Charleston | P20 Human Services | $3.3M | 1 |
| GREER RELIEF AND RESOURCES AGENCY | Greer | P40Z Human Services | $3.3M | 0 |
| SUMTER COUNTY COMMISSION ON ALCOHOL | Sumter | F20Z Mental Health & Crisis Intervention | $3.3M | 1 |
| NEWBERRY OPERA HOUSE FOUNDATION | Newberry | A6A0 Arts, Culture & Humanities | $3.3M | 2 |
| FRIENDS OF CAROLINE HOSPICE OF BEAU | Ridgeland | — | $3.3M | 0 |
| GIRL SCOUTS OF EASTERN SOUTH CAROLINA | North Charleston | O42 Youth Development | $3.3M | 1 |
| TAYLORS FREE MEDICAL CLINIC INC | Taylors | E32 Health Care | $3.3M | 1 |
| ST JOHN'S CHRISTIAN ACADEMY | Moncks Corner | B20 Education | $3.2M | 0 |
| BELTON PREPARATORY ACADEMY INC | Belton | B29 Education | $3.2M | 0 |
| BEAUFORT-JASPER YMCA OF THE LOWCOUNTRY INC | Port Royal | — | $3.2M | 1 |
| THE PALMETTO CLUB OF COLUMBIA | Columbia | — | $3.2M | 0 |
| SEA ISLAND HABITAT FOR HUMANITY | Johns Island | — | $3.2M | 1 |
| FACT FORWARD | Columbia | B99Z Education | $3.2M | 2 |
| SOUTH CAROLINA STATE UNIVERSITY | Orangeburg | B190 Education | $3.2M | 3 |
| GLOBAL WATER CENTER | North Charleston | Q30 International, Foreign Affairs & National Security | $3.2M | 2 |
| COMMUNITYWORKS INC | Greenville | L82 Housing & Shelter | $3.2M | 1 |
| GREENVILLE CLASSICAL ACADEMY | Greenville | B24 Education | $3.1M | 1 |
| CHAPMAN CULTURAL CENTER INC | Spartanburg | A260 Arts, Culture & Humanities | $3.1M | 1 |
