| Cure Sanfilippo Foundation | Columbia | H80 Medical Research | $2.8M | 3 |
| MOBILE MEALS OF SPARTANBURG COUNTY INC | Spartanburg | K36Z Food, Agriculture & Nutrition | $2.8M | 1 |
| MY SISTER'S HOUSE INC | North Charleston | P430 Human Services | $2.8M | 1 |
| FAMILY CONNECTION OF | Columbia | P40Z Human Services | $2.8M | 0 |
| SCAGO EDUCATIONAL FACILITIES CORP | Greer | B11 Education | $2.8M | 1 |
| SOUTH CAROLINA STATE MUSEUM FOUNDATION | Columbia | A115 Arts, Culture & Humanities | $2.8M | 0 |
| C P LEGACY FOUNDATION OF SUMTER SC INC | Sumter | L22 Housing & Shelter | $2.8M | 0 |
| EAST LINK ACADEMY | Greenville | B29 Education | $2.7M | 0 |
| SOUTH ATLANTIC CONFERENCE | Rock Hill | N70Z Recreation & Sports | $2.7M | 1 |
| Partners In Hope Inc | Loris | L21 Housing & Shelter | $2.7M | 0 |
| DORCHESTER PAWS | Summerville | D200 Animal-Related | $2.7M | 1 |
| LANCASTER CHILDRENS HOME | Lancaster | — | $2.7M | 0 |
| SELF REGIONAL HEALTHCARE FOUNDATION | Greenwood | — | $2.7M | 0 |
| HERMAN L ANDERSON INC | Conway | L22 Housing & Shelter | $2.7M | 0 |
| SCAGO EDUCATIONAL FACILITIES CORP | Union | B11 Education | $2.7M | 0 |
| THE FULLERTON FOUNDATION | Gaffney | B82 Education | $2.7M | 14 |
| Trent Hill Center for Children & Families | Hartsville | P30 Human Services | $2.7M | 2 |
| Cannon Street YMCA (6094) | Charleston | — | $2.7M | 1 |
| CHILDREN IN CRISIS IN DORCHESTER COUNTY | Summerville | P32 Human Services | $2.7M | 1 |
| BOYS AND GIRLS CLUB OF THE PEE DEE AREA | Florence | O21Z Youth Development | $2.7M | 1 |
| LB FOUNDATION | Greenville | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $2.7M | 2 |
| SPCA ALBRECHT CENTER FOR ANIMAL WELFARE | Aiken | D200 Animal-Related | $2.7M | 0 |
| MIDDLE TYGER COMMUNITY CENTER | Lyman | N31 Recreation & Sports | $2.6M | 1 |
| PROJECT REST | Spartanburg | P430 Human Services | $2.6M | 1 |
| The MCA Foundation | Spartanburg | T31 Philanthropy, Voluntarism & Grantmaking Foundations | $2.6M | 0 |
| SPINKS FAMILY FOUNDATION | Greenville | T99 Philanthropy, Voluntarism & Grantmaking Foundations | $2.6M | 0 |
| FAMILY PRESERVATION COMMUNITY | Columbia | P32 Human Services | $2.6M | 1 |
| PENDLETON PLACE INC | Greenville | P700 Human Services | $2.6M | 1 |
| JEWISH ENDOWMENT FOUNDATION OF SOUTH | N Charleston | T22Z Philanthropy, Voluntarism & Grantmaking Foundations | $2.6M | 2 |
| BAKALA FOUNDATION USA | Greenville | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $2.6M | 4 |
| CHARLESTON DEVELOPMENT ACADEMY | Charleston | B29 Education | $2.6M | 1 |
| ARRAS FOUNDATION | Lancaster | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $2.6M | 12 |
| Williamsburg Academy Inc | Kingstree | B24Z Education | $2.6M | 0 |
| NARROWAY PRODUCTIONS INC | Fort Mill | X80 Religion-Related | $2.6M | 2 |
| GRASSY POND WATER COMPANY INC | Gaffney | — | $2.6M | 0 |
| COUNCIL OF AUTISM SERVICE PROVIDERS INC | Lexington | S46 Community Improvement & Capacity Building | $2.6M | 3 |
| BENJAMIN E MAYS FAMILY RESOURCE CTR | Pacolet | P20 Human Services | $2.6M | 1 |
| WACCAMAW PARK PUBLIC CHARTER SCHOOLS INC | Myrtle Beach | B29 Education | $2.6M | 1 |
| Pine Ridge Fire Department | Summerville | M24 Public Safety, Disaster Preparedness & Relief | $2.6M | 0 |
| The Camp Cole Foundation Inc | Columbia | P20 Human Services | $2.6M | 1 |
| TRICO WATER COMPANY INC | Dillon | — | $2.6M | 6 |
| CHILDREN'S CENTER AT USC | Columbia | B21 Education | $2.6M | 0 |
| GATEWAY HOUSE INC | Greenville | F30Z Mental Health & Crisis Intervention | $2.6M | 1 |
| LAURENS ACADEMY INC | Laurens | B20Z Education | $2.6M | 1 |
| South Carolina Association of Pregnancy | Aiken | P45 Human Services | $2.6M | 1 |
| The Turning Point of South Carolina Inc | Greenville | L41 Housing & Shelter | $2.6M | 1 |
| CHAPIN WE CARE CENTER | Chapin | X21 Religion-Related | $2.5M | 1 |
| Lutheran Homes of South Carolina Foundation | Irmo | P110 Human Services | $2.5M | 5 |
| THE COOPER RIVER BRIDGE RUN INC | Mount Pleasant | N60 Recreation & Sports | $2.5M | 1 |
| A&T CARE | Kershaw | E92 Health Care | $2.5M | 0 |
