| Independent Insurance Agents and Brokers of South Carolina | Columbia | — | $1.9M | 1 |
| ASSOCIATION FOR EDUCATION IN | Columbia | A030 Arts, Culture & Humanities | $1.9M | 1 |
| PIEDMONT WOMEN'S CENTER | Greenville | P400 Human Services | $1.9M | 2 |
| UNITY HEALTH ON MAIN | Greenville | E32 Health Care | $1.9M | 1 |
| WILLIAMSBURG COMMUNITY HEALTH FOUNDATION | Kingstree | E60 Health Care | $1.9M | 0 |
| SENIOR ACTION INC | Greenville | P81Z Human Services | $1.9M | 1 |
| BLUE RIDGE COUNCIL INC | Greenville | — | $1.8M | 1 |
| Plumbers & Pipefitters LU 421 Training Fund | North Charleston | B30 Education | $1.8M | 1 |
| BARRIER ISLANDS FREE MEDICAL CLINIC | Johns Island | E32 Health Care | $1.8M | 3 |
| SOUTH CAROLINA GOVERNORS SCHOOL FOR | Columbia | B25Z Education | $1.8M | 1 |
| BROOKLAND CENTER FOR COMMUNITY | West Columbia | P20 Human Services | $1.8M | 1 |
| GREAT LAKES OUTREACH INC | Charleston | X90 Religion-Related | $1.8M | 1 |
| MOUNT PLEASANT SOCCER BOOSTER CLUB INC | Mt Pleasant | — | $1.8M | 2 |
| CASAFAMILY SYSTEMS | Orangeburg | — | $1.8M | 2 |
| GREENVILLE THEATRE | Greenville | A650 Arts, Culture & Humanities | $1.8M | 1 |
| GREENVILLE RE-DEVELOPMENT CORPORATION | Greenville | L20 Housing & Shelter | $1.8M | 0 |
| Force Blue Inc | Mount Pleasant | C32 Environment | $1.8M | 0 |
| Family YMCA of Greater Florence | Florence | — | $1.8M | 1 |
| SOUTHEASTERN CHILDREN'S HOME INC | Duncan | P70Z Human Services | $1.8M | 2 |
| MAY RIVER MONTESSORI | Bluffton | B210 Education | $1.8M | 1 |
| MENTAL HEALTH AMERICA OF SOUTH | Cayce | F80Z Mental Health & Crisis Intervention | $1.8M | 1 |
| South Carolina Ballet | Columbia | A630 Arts, Culture & Humanities | $1.8M | 1 |
| CONWAY HOSPITAL FOUNDATION INC | Conway | E22I Health Care | $1.8M | 3 |
| PATRICK HENRY ACADEMY INC | Estill | B20Z Education | $1.8M | 1 |
| BRIDGE NORTH CHARLESTON | North Charleston | L20 Housing & Shelter | $1.8M | 0 |
| HASMUKH AND GITA RAMA FOUNDATION | Greenville | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $1.8M | 0 |
| MYRTLE BEACH REGIONAL ECONOMIC | Conway | — | $1.8M | 0 |
| INTERNATIONAL PRIMATE PROTECTION | Summerville | D20Z Animal-Related | $1.8M | 0 |
| SCBIO | Greenville | — | $1.8M | 2 |
| UNITED WAY OF THE LAKELANDS | Greenwood | — | $1.8M | 1 |
| UNITED WAY OF HORRY COUNTY INC | Myrtle Beach | T70Z Philanthropy, Voluntarism & Grantmaking Foundations | $1.8M | 1 |
| FAIRFIELD FACILITIES CORPORATION | Winnsboro | Z99 Unknown | $1.8M | 0 |
| NEIGHBORHOOD CANCER CONNECTION | Greenville | — | $1.8M | 1 |
| PROGRAMS FOR EXCEPTIONAL PEOPLE | Bluffton | P82 Human Services | $1.8M | 1 |
| FURMAN UNIVERSITY FOUNDATION INC | Greenville | B99 Education | $1.8M | 1 |
| Coast Futbol Alliance Inc | Murrells Inlet | O20Z Youth Development | $1.8M | 1 |
| PATHWAYS COMMUNITY CENTER INC | Rock Hill | P28 Human Services | $1.7M | 0 |
| SOUTH CAROLINA TRUCKING ASSOCIATION | Columbia | — | $1.7M | 2 |
| PATHWAYS TO HEALING | Columbia | F42Z Mental Health & Crisis Intervention | $1.7M | 1 |
| Providence Classical School | Rock Hill | B24 Education | $1.7M | 3 |
| Scout Family Foundation | Summerville | — | $1.7M | 0 |
| TN DEVELOPMENT CORPORATION | Columbia | L210 Housing & Shelter | $1.7M | 0 |
| SCAGO EFC FOR COLLETON SCHOOL DISTRICT | Walterboro | B11 Education | $1.7M | 2 |
| DABO'S ALL IN TEAM FOUNDATION | Clemson | T12 Philanthropy, Voluntarism & Grantmaking Foundations | $1.7M | 0 |
| Head & Neck Cancer Alliance Inc | Charleston | G30 Diseases, Disorders & Medical Disciplines | $1.7M | 3 |
| Myrtle Beach Downtown Alliance Inc | Myrtle Beach | S20 Community Improvement & Capacity Building | $1.7M | 0 |
| MIDLAND VALLEY CHRISTIAN ACADEMY | Clearwater | B20 Education | $1.7M | 4 |
| ST ANDREWS CHURCH - MT PLEASANT | Mount Pleasant | X11 Religion-Related | $1.7M | 2 |
| OUR LADY OF MERCY COMMUNITY OUTREACH | Johns Island | — | $1.7M | 2 |
| AGFIRST FARM CREDIT COUNCIL INC | Columbia | — | $1.7M | 1 |
