| LIGHTHOUSE MINISTRIES FLORENCE | Florence | P60Z Human Services | $669k | 1 |
| PALMETTO WELFARE RETIREE BENEFIT | Walterboro | Y43 Mutual & Membership Benefit | $668k | 1 |
| THE COMPLETE STUDENT | Port Royal | B24 Education | $667k | 0 |
| SOUTH CAROLINA OPTOMETRIC | Columbia | — | $665k | 1 |
| TRUSTUS INC | Columbia | A65Z Arts, Culture & Humanities | $665k | 0 |
| BEAUFORT REGIONAL CHAMBER OF COMMERCE | Beaufort | — | $665k | 0 |
| BOYKIN SPANIEL RESCUE INC | Boiling Springs | D20 Animal-Related | $665k | 4 |
| WILDERNESS WAY CAMP SCHOOL INC | Fair Play | P30Z Human Services | $664k | 2 |
| YAGER FREEDOM FOUNDATION | Fort Mill | X20 Religion-Related | $664k | 0 |
| CERAMIC TILE EDUCATION | Anderson | J22 Employment | $662k | 2 |
| MT PISGAH APARTMENTS INC | West Columbia | — | $661k | 0 |
| OSWEGO RURAL WATER COMPANY | Sumter | — | $660k | 0 |
| CHARLESTON WATERKEEPER | Mount Pleasant | C32 Environment | $659k | 1 |
| USS YORKTOWN FOUNDATION | Mt Pleasant | A54 Arts, Culture & Humanities | $659k | 0 |
| THE GOSPEL HOUR INC | Taylors | X20Z Religion-Related | $659k | 1 |
| JENKINSVILLE WATER COMPANY INC | Jenkinsville | — | $658k | 0 |
| Rho Chapter Kappa Alpha Housing Corp | Columbia | S47 Community Improvement & Capacity Building | $657k | 0 |
| FLORENCE-DARLINGTON TECHNICAL COLLEGE | Florence | B42I Education | $655k | 0 |
| AIKEN LAND CONSERVANCY INC | Aiken | C340 Environment | $655k | 4 |
| CAROMI RURAL VOL FIRE DEPARTME | Ladson | M24Z Public Safety, Disaster Preparedness & Relief | $655k | 0 |
| SOVEREIGN MILITARY ORDER OFTHE TEMPLE OF JERUSALEM | Murrells Inlet | — | $654k | 0 |
| ANGELS CLUB | Columbia | B80 Education | $654k | 2 |
| PRECIOUS ONE LEARNING CENTER INC | Florence | — | $654k | 0 |
| THE GLEASON FAMILY FOUNDATION INC | Hilton Head Island | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $653k | 0 |
| TRIDENT URBAN LEAGUE | Charleston | P20 Human Services | $653k | 0 |
| CHEROKEE COUNTY CHAMBER OF COMMERCE | Gaffney | — | $653k | 1 |
| Rock Hill Economic Development | Rock Hill | S310 Community Improvement & Capacity Building | $651k | 0 |
| Charleston Co Vol Rescue Squad Inc | North Charleston | M23Z Public Safety, Disaster Preparedness & Relief | $651k | 0 |
| DISCIPLES VILLAGE | Lexington | Q33 International, Foreign Affairs & National Security | $651k | 3 |
| SIX OAKS CEMETERY INC | Hilton Head | Y50 Mutual & Membership Benefit | $650k | 2 |
| BERKELEY ELECTRIC COOPERATIVE TRUST | Moncks Corner | T30Z Philanthropy, Voluntarism & Grantmaking Foundations | $650k | 9 |
| THE DELANEY FAMILY FOUNDATION | Kiawah Island | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $650k | 0 |
| THE PDMA ALLIANCE INC | York | S41 Community Improvement & Capacity Building | $650k | 0 |
| INCREASING HOPE | North Charleston | P51 Human Services | $649k | 1 |
| GRAND STRAND BUSINESS ALLIANCE | Myrtle Beach | S41 Community Improvement & Capacity Building | $649k | 0 |
| PIMLICO RURAL VOLUNTEER FIRE DEPARTMENT | Moncks Corner | M24 Public Safety, Disaster Preparedness & Relief | $648k | 0 |
| Saint James Day School | Charleston | B20 Education | $647k | 0 |
| Friendship Place Inc | Georgetown | L410 Housing & Shelter | $646k | 1 |
| NATIONAL ASSOCIATION FOR CONTINENCE | Charleston | — | $646k | 1 |
| Carolina Childrens Home | Columbia | P70 Human Services | $645k | 1 |
| JCC HOUSING CORPORATION | Charleston | — | $645k | 2 |
| PROSPERITY CHILDCARE INC | Lamar | P33 Human Services | $643k | 2 |
| SMART FAMILY FOUNDATION | Greenville | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $641k | 0 |
| MOD Dental Aesthetics | Charleston | G99 Diseases, Disorders & Medical Disciplines | $641k | 0 |
| Palmetto Promise Institute | Columbia | E057 Health Care | $640k | 2 |
| SHRINERS INTERNATIONAL | Mount Pleasant | — | $639k | 0 |
| MT ZION AME APARTMENTS INC | West Columbia | L22 Housing & Shelter | $639k | 0 |
| FOOTHILLS CARE CENTER INC | Seneca | E400 Health Care | $638k | 1 |
| A FATHERS WAY | Lancaster | P400 Human Services | $638k | 1 |
| INTERNATIONAL UNION OF OPERATING | Graniteville | — | $638k | 2 |
