| THE JIM PARKE FOUNDATION C/O MARILYN J PARKE | Seneca | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $747k | 0 |
| CHARLESTON WATERKEEPER | Mount Pleasant | C32 Environment | $746k | 1 |
| PHIFERJOHNSON FOUNDATION | Spartanburg | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $745k | 0 |
| UNITED CHRISTIAN MINISTRIES | Easley | P600 Human Services | $744k | 1 |
| SPARTANBURG COUNTY HISTORICAL ASSOC | Spartanburg | — | $744k | 0 |
| INDIAN WATERS COUNCIL ITA | Columbia | — | $743k | 0 |
| SCAGO Educational Facilities Corporation for Sumter County School District | Sumter | B11 Education | $743k | 0 |
| THE RAPE CRISIS CENTER SERVING HORRY AND GEORGETOWN COUNTIES INC | Myrtle Beach | B90 Education | $742k | 0 |
| THE PENNELL FAMILY FOUNDATION | Greenville | A12 Arts, Culture & Humanities | $742k | 0 |
| CCES ENDOWMENT CORPORATION | Greenville | G12 Diseases, Disorders & Medical Disciplines | $742k | 0 |
| BC Corp | Greenville | B28 Education | $741k | 1 |
| BEYOND BASIC LIFE SKILLS | Summerville | P80 Human Services | $740k | 2 |
| MERRIWETHER VOLUNTEER FIRE DEPARTMENT | North Augusta | — | $739k | 0 |
| RIVER'S EDGE RETREAT INC | Columbia | O50 Youth Development | $737k | 0 |
| LOWCOUNTRY LEGAL VOLUNTEERS | Bluffton | I80 Crime & Legal-Related | $737k | 1 |
| BETTER BUSINESS BUREAU OF THE UPSTATE INC | Greenville | — | $736k | 1 |
| JCC HOUSING CORPORATION | Charleston | — | $735k | 1 |
| JOHNSONVILLE FIRE DEPARTMENT INC | Johnsonville | — | $734k | 2 |
| FRIENDS OF HONEY HILL | Ridgeland | A80 Arts, Culture & Humanities | $732k | 0 |
| WE ARE FAMILY | North Charleston | R20 Civil Rights, Social Action & Advocacy | $730k | 1 |
| SCIENTIFIC EQUIPMENT AND FURNITURE ASSOCIATION | Columbia | — | $730k | 0 |
| GIVING MINISTRY FOUNDATION | Graniteville | T12 Philanthropy, Voluntarism & Grantmaking Foundations | $730k | 0 |
| FOOTHILLS CARE CENTER INC | Seneca | E400 Health Care | $730k | 1 |
| BREAD OF LIFE MISSIONS | Hanahan | P20 Human Services | $729k | 2 |
| Fort Mill Care Center Inc | Fort Mill | P600 Human Services | $729k | 0 |
| LEXINGTON MEDICAL CENTER AUXILIARY | West Columbia | — | $728k | 0 |
| INTERNATIONAL FOUNDATION FOR GASTROINTES | Mt Pleasant | B99Z Education | $725k | 2 |
| CHESTERFIELD COUNTY FIRST STEPS TO SCHOOL READINESS PARTNERSHIP | Greenwood | B012 Education | $725k | 0 |
| HORRY COUNTY FIRST STEPS TO SCHOOL READINESS PARTNERSHIP | Greenwood | B190 Education | $723k | 0 |
| THE HARTNESS FOUNDATION ROBERT G HARTNESS | Greer | T22 Philanthropy, Voluntarism & Grantmaking Foundations | $721k | 0 |
| MISSION HOPE FOUNDATION | Columbia | X40 Religion-Related | $721k | 4 |
| DEFEND THE FATHERLESS INC | Fort Mill | P20 Human Services | $721k | 1 |
| BEAUFORT WATER FESTIVAL | Beaufort | — | $720k | 0 |
| FC CHARLESTON | Mount Pleasant | N64 Recreation & Sports | $720k | 0 |
| Better Business Bureau Inc | Columbia | — | $720k | 1 |
| Dominion Family Services Inc | Spartanburg | P30 Human Services | $718k | 0 |
| R-LCOA HOUSING DEVELOPMENT CORP INC | Columbia | L200 Housing & Shelter | $718k | 0 |
| NORTH WALTERBORO CHRISTIAN ACADEMY | Walterboro | B20 Education | $717k | 0 |
| SOUTH CAROLINA APPLESEED LEGAL JUSTICE CENTER | Columbia | R20 Civil Rights, Social Action & Advocacy | $717k | 2 |
| JOHN M RIVERS JR FOUNDATION | Charleston | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $716k | 0 |
| ARROWS ACADEMY OF SOUTH CAROLINA | Columbia | B24 Education | $716k | 3 |
| TENACIOUS GRACE MINISTRIES INC | Florence | X20 Religion-Related | $716k | 3 |
| FLORENCE COUNTY DISABILITIES FOUNDATION | Lake City | P82Z Human Services | $716k | 1 |
| SANTUCK HEBRON WATER COMPANY INC | Carlisle | K20 Food, Agriculture & Nutrition | $715k | 0 |
| HILTON HEAD AREA REALTORS | Hilton Head Island | — | $714k | 1 |
| WINE AND SPIRIT WHOLESALERS ASSOC | Columbia | S40 Community Improvement & Capacity Building | $713k | 1 |
| Pure Theatre | Charleston | A65 Arts, Culture & Humanities | $713k | 1 |
| Lee County School Facilities Inc | Bishopville | B11 Education | $713k | 0 |
| PHILLIS WHEATLEY ASSOCIATION | Greenville | P20 Human Services | $713k | 1 |
| Horizons Christian Academy | Chester | T20 Philanthropy, Voluntarism & Grantmaking Foundations | $713k | 0 |
